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adhesion protein FadA
FadA (Fusobacterium adhesin A) is an adhesin which forms two alpha helices that form an intra-molecular coiled-coil arrangement. [1]. 16030227. Identification and characterization of a novel adhesin unique to. oral fusobacteria.. Han YW, Ikegami A, Rajanna C, Kawsar HI, Zhou Y, Li M, Sojar HT,. Genco RJ, Kuramitsu HK, Deng CX;. J Bacteriol. 2005;187:5330-5340.. [2]. 18996848. Crystal structure of FadA adhesin from Fusobacterium nucleatum. reveals a novel oligomerization motif, the leucine chain.. Nithianantham S, Xu M, Yamada M, Ikegami A, Shoham M, Han YW;. J Biol Chem. 2009;284:3865-3872. (from Pfam)
adhesion protein FadA binds to surface proteins of oral mucosal cells; its oligomerization, filament formation/assembly, and binding to host cells is mediated by a novel structural motif called the leucine chain
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