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Select item 110615981.

Sotorasib Is a Pan-RAS^G12C Inhibitor Capable of Driving Clinical Response in NRAS^G12C Cancers

Douglas A. Rubinson, Noritaka Tanaka, Ferran Fece de la Cruz, Kevin S. Kapner, Michael H. Rosenthal, Bryanna L. Norden, Haley Barnes, Sara Ehnstrom, Alvin A. Morales-Giron, Lauren K. Brais, Christopher T. Lemke, Andrew J. Aguirre, Ryan B. Corcoran

Cancer Discov. 2024 May 1; 14(5): 727–736. Published online 2024 Jan 18. doi: 10.1158/2159-8290.CD-23-1138

PMCID:: PMC11061598

Abstract Article PDF–12M

Select item 109942472.

The Impact of Exuberance on Equipoise in Oncology Clinical Trials: Sotorasib as Archetype

Tito Fojo, Meredith LaRose, Susan E Bates

Oncologist. 2024 Apr; 29(4): 275–277. Published online 2024 Mar 18. doi: 10.1093/oncolo/oyae042

PMCID:: PMC10994247

Article PDF–122K

Select item 109600983.

Hepatotoxicity in patients with non-small cell lung cancer treated with sotorasib after prior immunotherapy: a comprehensive clinical and pharmacokinetic analysis

Sophie M. Ernst, Maaike M. Hofman, Tessa E. van der Horst, Marthe S. Paats, Frank W.J. Heijboer, Joachim G.J.V. Aerts, Daphne W. Dumoulin, Robin Cornelissen, Jan H. von der Thüsen, Peter de Bruijn, Esther Oomen-de Hoop, Ron H.J. Mathijssen, Stijn L.W. Koolen, Anne-Marie C. Dingemans

eBioMedicine. 2024 Apr; 102: 105074. Published online 2024 Mar 19. doi: 10.1016/j.ebiom.2024.105074

PMCID:: PMC10960098

Abstract Article PDF–699K

Select item 108551014.

Bioinformatics and Experimental Validation for Identifying Biomarkers Associated with AMG510 (Sotorasib) Resistance in KRAS^G12C-Mutated Lung Adenocarcinoma

Peng Lin, Wei Cheng, Xin Qi, Pinglu Zhang, Jianshe Xiong, Jing Li

Int J Mol Sci. 2024 Feb; 25(3): 1555. Published online 2024 Jan 26. doi: 10.3390/ijms25031555

PMCID:: PMC10855101

Abstract Article PDF–6.2M

Select item 107275605.

Sotorasib versus Docetaxel for treatment of US and Chinese patients with advanced non-small-cell lung cancer with KRAS p.G12C-mutated: A cost-effectiveness analysis to inform drug pricing

Yunlin Jiang, Mingye Zhao, Ruolin Liu, Xueping Zheng

Medicine (Baltimore) 2023 Dec 15; 102(50): e36387. Published online 2023 Dec 15. doi: 10.1097/MD.0000000000036387

PMCID:: PMC10727560

Abstract Article PDF–1.4M

Select item 105816266.

Clinical and Genomic Features of Response and Toxicity to Sotorasib in a Real-World Cohort of Patients With Advanced KRAS G12C-Mutant Non–Small Cell Lung Cancer

Rohit Thummalapalli, Ezra Bernstein, Benjamin Herzberg, Bob T. Li, Afsheen Iqbal, Isabel Preeshagul, Fernando C. Santini, Juliana Eng, Marc Ladanyi, Soo-Ryum Yang, Ronglai Shen, Piro Lito, Gregory J. Riely, Joshua K. Sabari, Kathryn C. Arbour

JCO Precis Oncol. 2023; 7: e2300030. Published online 2023 Jun 29. doi: 10.1200/PO.23.00030

PMCID:: PMC10581626

Abstract Article PDF–707K

Select item 105064567.

Sotorasib in KRAS p.G12C–Mutated Advanced Pancreatic Cancer

J.H. Strickler, H. Satake, T.J. George, R. Yaeger, A. Hollebecque, I. Garrido-Laguna, M. Schuler, T.F. Burns, A.L. Coveler, G.S. Falchook, M. Vincent, Y. Sunakawa, L. Dahan, D. Bajor, S.-Y. Rha, C. Lemech, D. Juric, M. Rehn, G. Ngarmchamnanrith, P. Jafarinasabian, Q. Tran, D.S. Hong

N Engl J Med. Author manuscript; available in PMC 2023 Sep 18.

Published in final edited form as: N Engl J Med. 2023 Jan 5; 388(1): 33–43. Published online 2022 Dec 21. doi: 10.1056/NEJMoa2208470

PMCID:: PMC10506456

Abstract Article PDF–399K

Select item 104147118.

Long-Term Outcomes and Molecular Correlates of Sotorasib Efficacy in Patients With Pretreated KRAS G12C-Mutated Non–Small-Cell Lung Cancer: 2-Year Analysis of CodeBreaK 100

Grace K. Dy, Ramaswamy Govindan, Vamsidhar Velcheti, Gerald S. Falchook, Antoine Italiano, Jürgen Wolf, Adrian G. Sacher, Toshiaki Takahashi, Suresh S. Ramalingam, Christophe Dooms, Dong-Wan Kim, Alfredo Addeo, Jayesh Desai, Martin Schuler, Pascale Tomasini, David S. Hong, Piro Lito, Qui Tran, Simon Jones, Abraham Anderson, Antreas Hindoyan, Wendy Snyder, Ferdinandos Skoulidis, Bob T. Li

J Clin Oncol. 2023 Jun 20; 41(18): 3311–3317. Published online 2023 Apr 25. doi: 10.1200/JCO.22.02524

PMCID:: PMC10414711

Abstract Article PDF–382K

Select item 103256309.

Clinical validation of Guardant360 CDx as a blood-based companion diagnostic for sotorasib

Joshua M. Bauml, Bob T. Li, Vamsidhar Velcheti, Ramaswamy Govindan, Alessandra Curioni-Fontecedro, Christophe Dooms, Toshiaki Takahashi, Andrew W. Duda, Justin I. Odegaard, Fernando Cruz-Guilloty, Liming Jin, Ying Zhang, Abraham Anderson, Ferdinandos Skoulidis

Lung Cancer. Author manuscript; available in PMC 2023 Jul 6.

Published in final edited form as: Lung Cancer. 2022 Apr; 166: 270–278. Published online 2021 Oct 19. doi: 10.1016/j.lungcan.2021.10.007

PMCID:: PMC10325630

Abstract Article PDF–753K

Select item 1030954210.

Incidence of Brain Metastases and Preliminary Evidence of Intracranial Activity With Sotorasib in Patients With KRAS^G12C-Mutant Non–Small-Cell Lung Cancer

Giuseppe Lamberti, Ayal Aizer, Biagio Ricciuti, Joao V. Alessi, Federica Pecci, Shu-Chi Tseng, Lynette M. Sholl, Mizuki Nishino, Mark M. Awad

JCO Precis Oncol. 2023; 7: e2200621. Published online 2023 Feb 21. doi: 10.1200/PO.22.00621

PMCID:: PMC10309542

Article PDF–1.6M

Select item 1030876711.

DNA replication stress and mitotic catastrophe mediate sotorasib addiction in KRAS^G12C-mutant cancer

Li-Wen Chiou, Chien-Hui Chan, Yu-Ling Jhuang, Ching-Yao Yang, Yung-Ming Jeng

J Biomed Sci. 2023; 30: 50. Published online 2023 Jun 29. doi: 10.1186/s12929-023-00940-4

PMCID:: PMC10308767

Abstract Article PDF–11M

Select item 1010481412.

Targeting PI3Kα overcomes resistance to KRas^G12C inhibitors mediated by activation of EGFR and/or IGF1R

Wei-liang Qi, Hui-yu Li, Yi Wang, Lan Xu, Jie-ting Deng, Xi Zhang, Yu-xiang Wang, Ling-hua Meng

Acta Pharmacol Sin. 2023 May; 44(5): 1083–1094. Published online 2022 Nov 21. doi: 10.1038/s41401-022-01015-0

PMCID:: PMC10104814

Abstract Article PDF–5.1M

Select item 1000181913.

A Novel Combination of Sotorasib and Metformin Enhances Cytotoxicity and Apoptosis in KRAS-Mutated Non-Small Cell Lung Cancer Cell Lines through MAPK and P70S6K Inhibition

Pedro Barrios-Bernal, José Lucio-Lozada, Maritza Ramos-Ramírez, Norma Hernández-Pedro, Oscar Arrieta

Int J Mol Sci. 2023 Mar; 24(5): 4331. Published online 2023 Feb 22. doi: 10.3390/ijms24054331

PMCID:: PMC10001819

Abstract Article PDF–2.2M

Select item 981437714.

PAK and PI3K pathway activation confers resistance to KRAS^G12C inhibitor sotorasib

Chien-Hui Chan, Li-Wen Chiou, Tsai-Yu Lee, Yun-Ru Liu, Tsung-Han Hsieh, Ching-Yao Yang, Yung-Ming Jeng

Br J Cancer. 2023 Jan 26; 128(1): 148–159. Published online 2022 Nov 1. doi: 10.1038/s41416-022-02032-w

PMCID:: PMC9814377

Abstract Article PDF–2.9M

Select item 971544615.

Sotorasib: A Review in KRAS G12C Mutation-Positive Non-small Cell Lung Cancer

Arnold Lee

Target Oncol. 2022; 17(6): 727–733. Published online 2022 Oct 31. doi: 10.1007/s11523-022-00922-w

Correction in:: Target Oncol. 2023; 18(1): 177.

PMCID:: PMC9715446

Abstract Article PDF–1.1M

Select item 963683916.

Editorial: Recent Approval of Sotorasib as the First Targeted Therapy for KRAS G12C-Mutated Advanced Non-Small Cell Lung Cancer (NSCLC)

Dinah V. Parums

Med Sci Monit. 2022; 28: e938746-1–e938746-3. Prepublished online 2022 Oct 25. Published online 2022 Nov 1. doi: 10.12659/MSM.938746

PMCID:: PMC9636839

Abstract Article PDF–157K

Select item 958361817.

Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations

Brian A. Lanman, Andrew T. Parsons, Stephan G. Zech

Acc Chem Res. 2022 Oct 18; 55(20): 2892–2903. Published online 2022 Sep 30. doi: 10.1021/acs.accounts.2c00479

PMCID:: PMC9583618

Abstract Article PDF–5.5M

Select item 949707118.

Inhibition of KRAS, MEK and PI3K Demonstrate Synergistic Anti-Tumor Effects in Pancreatic Ductal Adenocarcinoma Cell Lines

Yixuan Ma, Benjamin Schulz, Nares Trakooljul, Moosheer Al Ammar, Anett Sekora, Sina Sender, Frieder Hadlich, Dietmar Zechner, Frank Ulrich Weiss, Markus M. Lerch, Robert Jaster, Christian Junghanss, Hugo Murua Escobar

Cancers (Basel) 2022 Sep; 14(18): 4467. Published online 2022 Sep 14. doi: 10.3390/cancers14184467

PMCID:: PMC9497071

Abstract Article PDF–14M

Select item 911627419.

Sotorasib for Lung Cancers with KRAS p.G12C Mutation

F. Skoulidis, B.T. Li, G.K. Dy, T.J. Price, G.S. Falchook, J. Wolf, A. Italiano, M. Schuler, H. Borghaei, F. Barlesi, T. Kato, A. Curioni-Fontecedro, A. Sacher, A. Spira, S.S. Ramalingam, T. Takahashi, B. Besse, A. Anderson, A. Ang, Q. Tran, O. Mather, H. Henary, G. Ngarmchamnanrith, G. Friberg, V. Velcheti, R. Govindan

N Engl J Med. Author manuscript; available in PMC 2022 May 18.

Published in final edited form as: N Engl J Med. 2021 Jun 24; 384(25): 2371–2381. Published online 2021 Jun 4. doi: 10.1056/NEJMoa2103695

PMCID:: PMC9116274

Abstract Article PDF–857K

Select item 910691620.

Sotorasib, a KRAS^G12C inhibitor for non-small cell lung cancer

Arghya Ganguly, Euna Yoo

Trends Pharmacol Sci. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Trends Pharmacol Sci. 2022 Jun; 43(6): 536–537. Published online 2022 Apr 21. doi: 10.1016/j.tips.2022.03.011

PMCID:: PMC9106916

Article PDF–134K

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