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Select item 104741761.

The NEDD8-activating enzyme E1 UBA3 orchestrates the immunosuppressive microenvironment in lung adenocarcinoma via the NF-кB pathway

Xiongzhi Lin, Shuhan Yang, Caichuan Zhou, Chengcheng Ao, Dongsheng Sun

Med Oncol. 2023; 40(10): 286. Published online 2023 Sep 1. doi: 10.1007/s12032-023-02162-y

PMCID:: PMC10474176

Abstract Article PDF–1.8M

Select item 39722492.

Mutations in UBA3 Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 in Human Leukemic Cells

G. Wei Xu, Julia I. Toth, Sara R. da Silva, Stacey-Lynn Paiva, Julie L. Lukkarila, Rose Hurren, Neil Maclean, Mahadeo A. Sukhai, Rabindra N. Bhattacharjee, Carolyn A. Goard, Patrick T. Gunning, Sirano Dhe-Paganon, Matthew D. Petroski, Aaron D. Schimmer

PLoS One. 2014; 9(4): e93530. Published online 2014 Apr 1. doi: 10.1371/journal.pone.0093530

Correction in:: PLoS One. 2014; 9(10): e112004.

PMCID:: PMC3972249

Abstract Article PDF–2.4M

Select item 39442393.

Suppression of tumor angiogenesis by targeting the protein neddylation pathway

W-T Yao, J-F Wu, G-Y Yu, R Wang, K Wang, L-H Li, P Chen, Y-N Jiang, H Cheng, H W Lee, J Yu, H Qi, X-J Yu, P Wang, Y-W Chu, M Yang, Z-C Hua, H-Q Ying, R M Hoffman, L S Jeong, L-J Jia

Cell Death Dis. 2014 Feb; 5(2): e1059. Published online 2014 Feb 13. doi: 10.1038/cddis.2014.21

PMCID:: PMC3944239

Abstract Article PDF–4.1M

Select item 60316834.

Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways

Harbani Kaur Malik-Chaudhry, Zied Gaieb, Amanda Saavedra, Michael Reyes, Raphael Kung, Frank Le, Dimitrios Morikis, Jiayu Liao

Sci Rep. 2018; 8: 10108. Published online 2018 Jul 4. doi: 10.1038/s41598-018-28214-2

PMCID:: PMC6031683

Abstract Article PDF–1.7M

Select item 95767575.

A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer

Tiantian Xu, Qisheng Ma, Yanan Li, Qing Yu, Peichen Pan, Yawen Zheng, Zhijian Li, Xiufang Xiong, Tingjun Hou, Bin Yu, Hongmin Liu, Yi Sun

Signal Transduct Target Ther. 2022; 7: 354. Published online 2022 Oct 17. doi: 10.1038/s41392-022-01182-w

PMCID:: PMC9576757

Abstract Article PDF–6.0M

Select item 42021636.

Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target

Qiang Gao, Guang-Yang Yu, Jie-Yi Shi, Li-Hui Li, Wen-Juan Zhang, Zhi-Chao Wang, Liu-Xiao Yang, Meng Duan, Hu Zhao, Xiao-Ying Wang, Jian Zhou, Shuang-Jian Qiu, Lak Shin Jeong, Li-Jun Jia, Jia Fan

Oncotarget. 2014 Sep; 5(17): 7820–7832. Published online 2014 Aug 4. doi: 10.18632/oncotarget.2309

PMCID:: PMC4202163

Abstract Article PDF–13M

Select item 28218317.

Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity

Danny T. Huang, Harold W. Hunt, Min Zhuang, Melanie D. Ohi, James M. Holton, Brenda A. Schulman

Nature. Author manuscript; available in PMC 2010 Feb 15.

Published in final edited form as: Nature. 2007 Jan 25; 445(7126): 394–398. Published online 2007 Jan 14. doi: 10.1038/nature05490

PMCID:: PMC2821831

Abstract Article PDF–869K

Select item 25874368.

Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1

Judith Souphron, M. Brett Waddell, Amir Paydar, Zeynep Tokgöz-Gromley, Martine F. Roussel, Brenda A. Schulman

Biochemistry. 2008 Aug 26; 47(34): 8961–8969. Published online 2008 Jul 25. doi: 10.1021/bi800604c

PMCID:: PMC2587436

Abstract Article PDF–3.8M

Select item 58988159.

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-mediated Cullin Neddylation

Jared T. Hammill, Daniel C. Scott, Jaeki Min, Michele C. Connelly, Gloria Holbrook, Fangyi Zhu, Amy Matheny, Lei Yang, Bhuvanesh Singh, Brenda A. Schulman, R. Kiplin Guy

J Med Chem. Author manuscript; available in PMC 2019 Apr 12.

Published in final edited form as: J Med Chem. 2018 Apr 12; 61(7): 2680–2693. Published online 2018 Mar 26. doi: 10.1021/acs.jmedchem.7b01277

PMCID:: PMC5898815

Abstract Article PDF–975K

Select item 497264710.

Neddylation requires glycyl-tRNA synthetase to protect activated E2

Zhongying Mo, Qian Zhang, Ze Liu, Janelle Lauer, Yi Shi, Litao Sun, Patrick R. Griffin, Xiang-Lei Yang

Nat Struct Mol Biol. Author manuscript; available in PMC 2016 Dec 27.

Published in final edited form as: Nat Struct Mol Biol. 2016 Aug; 23(8): 730–737. Published online 2016 Jun 27. doi: 10.1038/nsmb.3250

PMCID:: PMC4972647

Abstract Article PDF–2.4M

Select item 286255611.

A unique E1–E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8

Danny T. Huang, David W. Miller, Rose Mathew, Robert Cassell, James M. Holton, Martine F. Roussel, Brenda A. Schulman

Nat Struct Mol Biol. Author manuscript; available in PMC 2010 May 3.

Published in final edited form as: Nat Struct Mol Biol. 2004 Oct; 11(10): 927–935. Published online 2004 Sep 7. doi: 10.1038/nsmb826

PMCID:: PMC2862556

Abstract Article PDF–1.5M

Select item 138023612.

Single-Nucleotide Polymorphisms in NAGNAG Acceptors Are Highly Predictive for Variations of Alternative Splicing

Michael Hiller, Klaus Huse, Karol Szafranski, Niels Jahn, Jochen Hampe, Stefan Schreiber, Rolf Backofen, Matthias Platzer

Am J Hum Genet. 2006 Feb; 78(2): 291–302. Published online 2005 Dec 22. doi: 10.1086/500151

Correction in:: Am J Hum Genet. 2006 Apr; 78(4): 733.

PMCID:: PMC1380236

Abstract Article PDF–715K

Select item 31703913.

A new NEDD8-ligating system for cullin-4A

Fumio Osaka, Hiroshi Kawasaki, Noriko Aida, Mihoro Saeki, Tomoki Chiba, Seiichi Kawashima, Keiji Tanaka, Seishi Kato

Genes Dev. 1998 Aug 1; 12(15): 2263–2268. doi: 10.1101/gad.12.15.2263

PMCID:: PMC317039

Abstract Article PDF–374K

Select item 707657114.

Gossypol inhibits cullin neddylation by targeting SAG-CUL5 and RBX1-CUL1 complexes

Qing Yu, Zhiguo Hu, Yanwen Shen, Yihan Jiang, Peichen Pan, Tingjun Hou, Zhen-Qiang Pan, Jing Huang, Yi Sun

Neoplasia. 2020 Apr; 22(4): 179–191. Published online 2020 Mar 16. doi: 10.1016/j.neo.2020.02.003

PMCID:: PMC7076571

Abstract Article PDF–2.4M

Select item 541974315.

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

Kate E Coleman, Miklós Békés, Jessica R Chapman, Sarah B Crist, Mathew JK Jones, Beatrix M Ueberheide, Tony T Huang

eLife. 2017; 6: e24325. Published online 2017 May 5. doi: 10.7554/eLife.24325

PMCID:: PMC5419743

Abstract Article PDF–2.3M

Select item 846044716.

CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation

Sebastian Kostrhon, J. Rajan Prabu, Kheewoong Baek, Daniel Horn-Ghetko, Susanne von Gronau, Maren Klügel, Jérôme Basquin, Arno F. Alpi, Brenda A. Schulman

Nat Chem Biol. 2021; 17(10): 1075–1083. Published online 2021 Sep 13. doi: 10.1038/s41589-021-00858-8

PMCID:: PMC8460447

Abstract Article PDF–13M

Select item 344809717.

Identification of Cellular Proteins Required for Replication of Human Immunodeficiency Virus Type 1

Natallia Dziuba, Monique R. Ferguson, William A. O'Brien, Anthony Sanchez, Andrew J. Prussia, Natalie J. McDonald, Brian M. Friedrich, Guangyu Li, Michael W. Shaw, Jinsong Sheng, Thomas W. Hodge, Donald H. Rubin, James L. Murray

AIDS Res Hum Retroviruses. 2012 Oct; 28(10): 1329–1339. doi: 10.1089/aid.2011.0358

PMCID:: PMC3448097

Abstract Article PDF–611K

Select item 608604018.

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

Joanna Koszela, Nhan T. Pham, David Evans, Stefan Mann, Irene Perez-Pi, Steven Shave, Derek F. J. Ceccarelli, Frank Sicheri, Mike Tyers, Manfred Auer

BMC Biol. 2018; 16: 88. Published online 2018 Aug 10. doi: 10.1186/s12915-018-0554-z

PMCID:: PMC6086040

Abstract Article PDF–1.4M

Select item 272536019.

E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification

Danny T. Huang, Olivier Ayrault, Harold W. Hunt, Asad M. Taherbhoy, David M. Duda, Daniel C. Scott, Laura A. Borg, Geoffrey Neale, Peter J. Murray, Martine F. Roussel, Brenda A. Schulman

Mol Cell. Author manuscript; available in PMC 2009 Aug 27.

Published in final edited form as: Mol Cell. 2009 Feb 27; 33(4): 483–495. doi: 10.1016/j.molcel.2009.01.011

PMCID:: PMC2725360

Abstract Article PDF–3.7M

Select item 510887220.

A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes

Monique P.C. Mulder, Katharina Witting, Ilana Berlin, Jonathan N. Pruneda, Kuen-Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C.O. Vertegaal, Brenda A. Schulman, David Komander, Jacques Neefjes, Farid El Oualid, Huib Ovaa

Nat Chem Biol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Nat Chem Biol. 2016 Jul; 12(7): 523–530. Published online 2016 May 16. doi: 10.1038/nchembio.2084