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Select item 41146841.

The SBP2 protein central to selenoprotein synthesis contacts the human ribosome at expansion segment 7L of the 28S rRNA

Olga Kossinova, Alexey Malygin, Alain Krol, Galina Karpova

RNA. 2014 Jul; 20(7): 1046–1056. doi: 10.1261/rna.044917.114

PMCID:: PMC4114684

Article PDF–1019K

Select item 29935942.

Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

Erik Schoenmakers, Maura Agostini, Catherine Mitchell, Nadia Schoenmakers, Laura Papp, Odelia Rajanayagam, Raja Padidela, Lourdes Ceron-Gutierrez, Rainer Doffinger, Claudia Prevosto, Jian’an Luan, Sergio Montano, Jun Lu, Mireille Castanet, Nick Clemons, Matthijs Groeneveld, Perrine Castets, Mahsa Karbaschi, Sri Aitken, Adrian Dixon, Jane Williams, Irene Campi, Margaret Blount, Hannah Burton, Francesco Muntoni, Dominic O’Donovan, Andrew Dean, Anne Warren, Charlotte Brierley, David Baguley, Pascale Guicheney, Rebecca Fitzgerald, Alasdair Coles, Hill Gaston, Pamela Todd, Arne Holmgren, Kum Kum Khanna, Marcus Cooke, Robert Semple, David Halsall, Nicholas Wareham, John Schwabe, Lucia Grasso, Paolo Beck-Peccoz, Arthur Ogunko, Mehul Dattani, Mark Gurnell, Krishna Chatterjee

J Clin Invest. 2010 Dec 1; 120(12): 4220–4235. Published online 2010 Nov 15. doi: 10.1172/JCI43653

PMCID:: PMC2993594

Article PDF–1.8M

Select item 28583713.

Selenium Supplementation Fails to Correct the Selenoprotein Synthesis Defect in Subjects with SBP2 Gene Mutations

Lutz Schomburg, Alexandra M. Dumitrescu, Xiao-Hui Liao, Bassam Bin-Abbas, Johanna Hoeflich, Josef Köhrle, Samuel Refetoff

Thyroid. 2009 Mar; 19(3): 277–281. doi: 10.1089/thy.2008.0397

PMCID:: PMC2858371

Article PDF–81K

Select item 27587354.

Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X)

Caterina Di Cosmo, Neil McLellan, Xiao-Hui Liao, Kum Kum Khanna, Roy E. Weiss, Laura Papp, Samuel Refetoff

J Clin Endocrinol Metab. 2009 Oct; 94(10): 4003–4009. Published online 2009 Jul 14. doi: 10.1210/jc.2009-0686

PMCID:: PMC2758735

Article

Select item 26027865.

Functional characterization of alternatively spliced human SECISBP2 transcript variants

Laura V. Papp, Junning Wang, Derek Kennedy, Didier Boucher, Yan Zhang, Vadim N. Gladyshev, Ravindra N. Singh, Kum Kum Khanna

Nucleic Acids Res. 2008 Dec; 36(22): 7192–7206. Published online 2008 Nov 12. doi: 10.1093/nar/gkn829

PMCID:: PMC2602786

Article PDF–2.2M

Select item 21691516.

SBP2 Binding Affinity Is a Major Determinant in Differential Selenoprotein mRNA Translation and Sensitivity to Nonsense-Mediated Decay

Jeffrey E. Squires, Ilko Stoytchev, Erin P. Forry, Marla J. Berry

Mol Cell Biol. 2007 Nov; 27(22): 7848–7855. Published online 2007 Sep 10. doi: 10.1128/MCB.00793-07

PMCID:: PMC2169151

Article PDF–239K

Select item 14891627.

The Redox State of SECIS Binding Protein 2 Controls Its Localization and Selenocysteine Incorporation Function

Laura V. Papp, Jun Lu, Frank Striebel, Derek Kennedy, Arne Holmgren, Kum Kum Khanna

Mol Cell Biol. 2006 Jul; 26(13): 4895–4910. doi: 10.1128/MCB.02284-05

PMCID:: PMC1489162

Article PDF–939K

Select item 13703398.

The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding.

Christine Allmang, Philippe Carbon, Alain Krol

RNA. 2002 Oct; 8(10): 1308–1318. doi: 10.1017/s1355838202020034

PMCID:: PMC1370339

Summary PDF–1.1M

Select item 3059079.

SECIS–SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy

Susan C. Low, Elisabeth Grundner-Culemann, John W. Harney, Marla J. Berry

EMBO J. 2000 Dec 15; 19(24): 6882–6890. doi: 10.1093/emboj/19.24.6882

PMCID:: PMC305907

Article PDF–286K

Select item 1006491810.

Structure of the mammalian ribosome as it decodes the selenocysteine UGA codon

Tarek Hilal, Benjamin Y. Killam, Milica Grozdanović, Malgorzata Dobosz-Bartoszek, Justus Loerke, Jörg Bürger, Thorsten Mielke, Paul R. Copeland, Miljan Simonović, Christian M. T. Spahn

Science. Author manuscript; available in PMC 2023 Mar 31.

Published in final edited form as: Science. 2022 Jun 17; 376(6599): 1338–1343. Published online 2022 Jun 16. doi: 10.1126/science.abg3875

PMCID:: PMC10064918

Article PDF–2.6M

Select item 623760611.

Selenium‐sensitive miRNA‐181a‐5p targeting SBP2 regulates selenoproteins expression in cartilage

Zixin Min, Yuanxu Guo, Mengyao Sun, Safdar Hussain, Yitong Zhao, Dongxian Guo, Huang Huang, Lisong Heng, Fujun Zhang, Qilan Ning, Yan Han, Peng Xu, Nannan Zhong, Jian Sun, Shemin Lu

J Cell Mol Med. 2018 Dec; 22(12): 5888–5898. Published online 2018 Sep 24. doi: 10.1111/jcmm.13858

PMCID:: PMC6237606

Article PDF–2.6M

Select item 332300112.

Selenocysteine Insertion Sequence (SECIS)-binding Protein 2 Alters Conformational Dynamics of Residues Involved in tRNA Accommodation in 80 S Ribosomes

Kelvin Caban, Paul R. Copeland

J Biol Chem. 2012 Mar 23; 287(13): 10664–10673. Published online 2012 Feb 3. doi: 10.1074/jbc.M111.320929

PMCID:: PMC3323001

Article PDF–1.8M

Select item 307384213.

A Novel Protein Domain Induces High Affinity Selenocysteine Insertion Sequence Binding and Elongation Factor Recruitment

Jesse Donovan, Kelvin Caban, Ruchira Ranaweera, Jonathan N. Gonzalez-Flores, Paul R. Copeland

J Biol Chem. 2008 Dec 12; 283(50): 35129–35139. doi: 10.1074/jbc.M806008200

PMCID:: PMC3073842

Article PDF–1.6M

Select item 30556414.

A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs

Paul R. Copeland, Julia E. Fletcher, Bradley A. Carlson, Dolph L. Hatfield, Donna M. Driscoll

EMBO J. 2000 Jan 17; 19(2): 306–314. doi: 10.1093/emboj/19.2.306

Correction in:: EMBO J. 2000 Dec 1; 19(23): 6634.

PMCID:: PMC305564

Article PDF–442K

Select item 865802015.

Human Genetic Disorders Resulting in Systemic Selenoprotein Deficiency

Erik Schoenmakers, Krishna Chatterjee

Int J Mol Sci. 2021 Dec; 22(23): 12927. Published online 2021 Nov 29. doi: 10.3390/ijms222312927

PMCID:: PMC8658020

Article PDF–1.8M

Select item 617277716.

The hsa-miR-181a-5p reduces oxidation resistance by controlling SECISBP2 in osteoarthritis

Jianli Xue, Zixin Min, Zhuqing Xia, Bin Cheng, Binshang Lan, Fujun Zhang, Yan Han, Kunzheng Wang, Jian Sun

BMC Musculoskelet Disord. 2018; 19: 355. Published online 2018 Oct 5. doi: 10.1186/s12891-018-2273-6

PMCID:: PMC6172777

Article PDF–3.2M

Select item 187461317.

An improved definition of the RNA-binding specificity of SECIS-binding protein 2, an essential component of the selenocysteine incorporation machinery

A. Cléry, V. Bourguignon-Igel, C. Allmang, A. Krol, C. Branlant

Nucleic Acids Res. 2007 Mar; 35(6): 1868–1884. Published online 2007 Mar 1. doi: 10.1093/nar/gkm066

PMCID:: PMC1874613

Article PDF–977K

Select item 560522818.

SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation

Anne-Sophie Gribling-Burrer, Michael Leichter, Laurence Wurth, Alexandra Huttin, Florence Schlotter, Nathalie Troffer-Charlier, Vincent Cura, Martine Barkats, Jean Cavarelli, Séverine Massenet, Christine Allmang

Nucleic Acids Res. 2017 May 19; 45(9): 5399–5413. Published online 2017 Jan 23. doi: 10.1093/nar/gkx031

PMCID:: PMC5605228

Article PDF–2.1M

Select item 270727619.

Known Turnover and Translation Regulatory RNA-Binding Proteins Interact with the 3’ UTR of SECIS-Binding Protein 2

Jodi Bubenik, Andrea Ladd, Carri A. Gerber, Michael Budiman, Donna Driscoll

RNA Biol. Author manuscript; available in PMC 2009 Jul 8.

Published in final edited form as: RNA Biol. 2009; 6(1): 73–83. Published online 2009 Jan 5. doi: 10.4161/rna.6.1.7569

PMCID:: PMC2707276

Article PDF–1.8M

Select item 855075920.

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja

eLife. 2021; 10: e65759. Published online 2021 Oct 27. doi: 10.7554/eLife.65759

PMCID:: PMC8550759

Article PDF–7.4M

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