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Select item 106251201.

KLF5 Promotes Tumor Progression and Parp Inhibitor Resistance in Ovarian Cancer

Yong Wu, Siyu Chen, Yang Shao, Ying Su, Qin Li, Jiangchun Wu, Jun Zhu, Hao Wen, Yan Huang, Zhong Zheng, Xiaojun Chen, Xingzhu Ju, Shenglin Huang, Xiaohua Wu, Zhixiang Hu

Adv Sci (Weinh) 2023 Nov; 10(31): 2304638. Published online 2023 Sep 13. doi: 10.1002/advs.202304638

PMCID:: PMC10625120

Article PDF–4.3M

Select item 89800702.

KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response

Xiaohui Shen, Yuchen Zhang, Zhuoqing Xu, Han Gao, Wenqing Feng, Wenchang Li, Yiming Miao, Zifeng Xu, Yaping Zong, Jingkun Zhao, Aiguo Lu

Cell Death Dis. 2022 Apr; 13(4): 303. Published online 2022 Apr 5. doi: 10.1038/s41419-022-04773-1

PMCID:: PMC8980070

Article PDF–6.0M

Select item 88168223.

Krüppel-like factor (KLF)5: An emerging foe of cardiovascular health

Dimitra Palioura, Antigone Lazou, Konstantinos Drosatos

J Mol Cell Cardiol. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: J Mol Cell Cardiol. 2022 Feb; 163: 56–66. Published online 2021 Oct 13. doi: 10.1016/j.yjmcc.2021.10.002

PMCID:: PMC8816822

Article PDF–1.2M

Select item 86426894.

Simvastatin treatment promotes proliferation of human dental pulp stem cells via modulating PI3K/AKT/miR‐9/KLF5 signalling pathway

Jing‐hui Wang, Dang‐en He

J Cell Mol Med. 2021 Dec; 25(23): 10892–10901. Published online 2021 Nov 19. doi: 10.1111/jcmm.16973

PMCID:: PMC8642689

Article PDF–930K

Select item 81523635.

KLF5 Is Activated by Gene Amplification in Gastric Cancer and Is Essential for Gastric Cell Proliferation

Wei Chen, Jian Zhang, Huafeng Fu, Xun Hou, Qiao Su, Yulong He, Dongjie Yang

Cells. 2021 May; 10(5): 1002. Published online 2021 Apr 24. doi: 10.3390/cells10051002

PMCID:: PMC8152363

Article PDF–3.3M

Select item 79697546.

Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer

Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Omer Kucuk, Wei Zhou, Jin-Tang Dong

Nat Commun. 2021; 12: 1714. Published online 2021 Mar 17. doi: 10.1038/s41467-021-21976-w

PMCID:: PMC7969754

Article PDF–9.2M

Select item 75445047.

Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma

Connor Rogerson, Samuel Ogden, Edward Britton, The OCCAMS Consortium, Yeng Ang, Andrew D Sharrocks

eLife. 2020; 9: e57189. Published online 2020 Sep 3. doi: 10.7554/eLife.57189

PMCID:: PMC7544504

Article PDF–2.1M

Select item 72930988.

High expression of Krüppel‐like factor 5 is associated with poor prognosis in patients with colorectal cancer

Yutaka Takagi, Nozomu Sakai, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Shigetsugu Takano, Daisuke Suzuki, Shingo Kagawa, Takashi Mishima, Eri Nakadai, Hideaki Miyauchi, Hisahiro Matsubara, Masayuki Ohtsuka

Cancer Sci. 2020 Jun; 111(6): 2078–2092. Published online 2020 May 5. doi: 10.1111/cas.14411

PMCID:: PMC7293098

Article PDF–2.1M

Select item 66825279.

Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer

Yilong Li, Rui Kong, Hongze Chen, Zhongjie Zhao, Le Li, Jiating Li, Jisheng Hu, Guangquan Zhang, Shangha Pan, Yongwei Wang, Gang Wang, Hua Chen, Bei Sun

Aging (Albany NY) 2019 Jul 31; 11(14): 5035–5057. Published online 2019 Jul 21. doi: 10.18632/aging.102096

PMCID:: PMC6682527

Article PDF–4.1M

Select item 650102710.

Knockdown of KLF5 promotes cisplatin‐induced cell apoptosis via regulating DNA damage checkpoint proteins in non‐small cell lung cancer

Hao Zhang, Fei Shao, Wei Guo, Yibo Gao, Jie He

Thorac Cancer. 2019 May; 10(5): 1069–1077. Published online 2019 Mar 21. doi: 10.1111/1759-7714.13046

PMCID:: PMC6501027

Article PDF–3.0M

Select item 649689211.

KLF5 strengthens drug resistance of ovarian cancer stem‐like cells by regulating survivin expression

Z. Dong, L. Yang, D. Lai

Cell Prolif. 2013 Aug; 46(4): 425–435. Published online 2013 Jul 21. doi: 10.1111/cpr.12043

PMCID:: PMC6496892

Article PDF–922K

Select item 615189312.

KLF5 promotes the tumorigenesis and metastatic potential of thyroid cancer cells through the NF-κB signaling pathway

Yuehua Ma, Qingzhu Wang, Fei Liu, Xiaojun Ma, Lina Wu, Feng Guo, Shuiying Zhao, Fengjuan Huang, Guijun Qin

Oncol Rep. 2018 Nov; 40(5): 2608–2618. Published online 2018 Sep 6. doi: 10.3892/or.2018.6687

PMCID:: PMC6151893

Article PDF–2.2M

Select item 576028913.

Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor

Xiaoyang Zhang, Peter S. Choi, Joshua M. Francis, Galen F. Gao, Joshua D. Campbell, Aruna Ramachandran, Yoichiro Mitsuishi, Gavin Ha, Juliann Shih, Francisca Vazquez, Aviad Tsherniak, Alison M. Taylor, Jin Zhou, Zhong Wu, Ashton C. Berger, Marios Giannakis, William C. Hahn, Andrew D. Cherniack, Matthew Meyerson

Cancer Discov. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Cancer Discov. 2018 Jan; 8(1): 108–125. Published online 2017 Sep 29. doi: 10.1158/2159-8290.CD-17-0532

PMCID:: PMC5760289

Article PDF–1.1M

Select item 541725014.

The Induction of KLF5 Transcription Factor by Progesterone Contributes to Progesterone-Induced Breast Cancer Cell Proliferation and Dedifferentiation

Rong Liu, Zhongmei Zhou, Dong Zhao, Ceshi Chen

Mol Endocrinol. July 1, 2011; 25(7): 1137–1144. Published online 2011 May 12. doi: 10.1210/me.2010-0497

PMCID:: PMC5417250

Article

Select item 471958315.

Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease

Kyoko Abe, Hisatoshi Sugiura, Yuichiro Hashimoto, Tomohiro Ichikawa, Akira Koarai, Mitsuhiro Yamada, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Masakazu Ichinose

Respir Res. 2016; 17: 7. Published online 2016 Jan 20. doi: 10.1186/s12931-016-0322-y

PMCID:: PMC4719583

Article PDF–2.8M

Select item 423245716.

Interruption of KLF5 acetylation converts its function from tumor suppressor to tumor promoter in prostate cancer cells

Xin Li, Baotong Zhang, Qiao Wu, Xinpei Ci, Ranran Zhao, Zhiqian Zhang, Siyuan Xia, Dan Su, Jie Chen, Gui Ma, Liya Fu, Jin-Tang Dong

Int J Cancer. Author manuscript; available in PMC 2016 Feb 15.

Published in final edited form as: Int J Cancer. 2015 Feb 15; 136(3): 536–546. Published online 2014 Jun 28. doi: 10.1002/ijc.29028

PMCID:: PMC4232457

Article PDF–1.2M

Select item 363835017.

Restoring KLF5 in Esophageal Squamous Cell Cancer Cells Activates the JNK Pathway Leading to Apoptosis and Reduced Cell Survival

Rohinton S Tarapore, Yizeng Yang, Jonathan P Katz

Neoplasia. 2013 May; 15(5): 472–480. doi: 10.1593/neo.122126

PMCID:: PMC3638350

Article PDF–2.4M

Select item 355317418.

Helicobacter Pylori Promotes the Expression of Krüppel-Like Factor 5, a Mediator of Carcinogenesis, In Vitro and In Vivo

Jennifer M. Noto, Tinatin Khizanishvili, Rupesh Chaturvedi, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Shradha S. Khurana, Johanna C. Sierra, Uma S. Krishna, Giovanni Suarez, Anne E. Powell, James R. Goldenring, Robert J. Coffey, Vincent W. Yang, Pelayo Correa, Jason C. Mills, Keith T. Wilson, Richard M. Peek, Jr.

PLoS One. 2013; 8(1): e54344. Published online 2013 Jan 23. doi: 10.1371/journal.pone.0054344

PMCID:: PMC3553174

Article PDF–1.0M

Select item 321332619.

Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-Like Factor 5 Expression by Ultrahigh-Throughput Screening

Agnieszka B. Bialkowska, Melissa Crisp, Thomas Bannister, Yuanjun He, Sarwat Chowdhury, Stephan Schürer, Peter Chase, Timothy Spicer, Franck Madoux, Chenlu Tian, Peter Hodder, Daniel Zaharevitz, Vincent W. Yang

Mol Cancer Ther. Author manuscript; available in PMC 2012 Nov 1.

Published in final edited form as: Mol Cancer Ther. 2011 Nov; 10(11): 2043–2051. Published online 2011 Sep 1. doi: 10.1158/1535-7163.MCT-11-0550

PMCID:: PMC3213326

Article PDF–1023K

Select item 319317020.

Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension

Audrey Courboulin, Véronique L Tremblay, Marjorie Barrier, Jolyane Meloche, Maria Helena Jacob, Mathilde Chapolard, Malik Bisserier, Roxane Paulin, Caroline Lambert, Steeve Provencher, Sébastien Bonnet

Respir Res. 2011; 12(1): 128. Published online 2011 Sep 27. doi: 10.1186/1465-9921-12-128

PMCID:: PMC3193170

Article PDF–4.0M

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