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Select item 83541021.

Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

Ashwin Narain, Pranjali Bhandare, Bikash Adhikari, Simone Backes, Martin Eilers, Lars Dölken, Andreas Schlosser, Florian Erhard, Apoorva Baluapuri, Elmar Wolf

Mol Cell. 2021 Aug 5; 81(15): 3110–3127.e14. doi: 10.1016/j.molcel.2021.06.016

PMCID:: PMC8354102

Article

Select item 78622862.

SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation

Jingting Li, Xiaojun Xu, Manisha Tiwari, Yifang Chen, Mackenzie Fuller, Varun Bansal, Pablo Tamayo, Soumita Das, Pradipta Ghosh, George L. Sen

Nat Commun. 2021; 12: 784. Published online 2021 Feb 4. doi: 10.1038/s41467-021-21067-w

PMCID:: PMC7862286

Article PDF–5.5M

Select item 75013063.

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Elisabeth Anne Adanma Obara, Diana Aguilar-Morante, Rikke Darling Rasmussen, Alex Frias, Kristoffer Vitting-Serup, Yi Chieh Lim, Kirstine Juul Elbæk, Henriette Pedersen, Lina Vardouli, Kamilla Ellermann Jensen, Jane Skjoth-Rasmussen, Jannick Brennum, Lucie Tuckova, Robert Strauss, Christoffel Dinant, Jiri Bartek, Petra Hamerlik

Nat Commun. 2020; 11: 4709. Published online 2020 Sep 18. doi: 10.1038/s41467-020-18549-8

PMCID:: PMC7501306

Article PDF–2.6M

Select item 63099214.

Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

Takayuki Nojima, Michael Tellier, Jonathan Foxwell, Claudia Ribeiro de Almeida, Sue Mei Tan-Wong, Somdutta Dhir, Gwendal Dujardin, Ashish Dhir, Shona Murphy, Nick J. Proudfoot

Mol Cell. 2018 Dec 20; 72(6): 970–984.e7. doi: 10.1016/j.molcel.2018.10.011

PMCID:: PMC6309921

Article PDF–3.6M

Select item 33024225.

The Cellular Protein SPT6 Is Required for Efficient Replication of Human Cytomegalovirus

Daniel Cygnar, Stacy Hagemeier, Daniel Kronemann, Wade A. Bresnahan

J Virol. 2012 Feb; 86(4): 2011–2020. doi: 10.1128/JVI.06776-11

PMCID:: PMC3302422

Article PDF–1.9M

Select item 99868956.

Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6

Jiantao Wang, Chuan Yang, Huan Cao, Jianwang Yang, Wenxia Meng, Miaomiao Yu, Lei Yu, Baoshan Wang

Cell Transplant. 2023 Jan-Dec; 32: 09636897231154574. Published online 2023 Feb 28. doi: 10.1177/09636897231154574

PMCID:: PMC9986895

Article PDF–7.2M

Select item 33055017.

Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR

Mirai Nakamura, Poornima Basavarajaiah, Emilie Rousset, Cyprien Beraud, Daniel Latreille, Imène-Sarah Henaoui, Irina Lassot, Bernard Mari, Rosemary Kiernan

Retrovirology. 2012; 9: 13. Published online 2012 Feb 8. doi: 10.1186/1742-4690-9-13

PMCID:: PMC3305501

Article PDF–1.8M

Select item 1123388.

Functional Interaction between Pleiotropic Transactivator pUL69 of Human Cytomegalovirus and the Human Homolog of Yeast Chromatin Regulatory Protein SPT6

Michael Winkler, Thomas aus dem Siepen, Thomas Stamminger

J Virol. 2000 Sep; 74(17): 8053–8064. doi: 10.1128/jvi.74.17.8053-8064.2000

PMCID:: PMC112338

Article PDF–2.2M

Select item 80247219.

SPT6 recruits SND1 to co‐activate human telomerase reverse transcriptase to promote colon cancer progression

Chaoliang Diao, Ping Guo, Wenjing Yang, Yao Sun, Yina Liao, Yue Yan, Anshi Zhao, Xin Cai, Jiaojiao Hao, Sheng Hu, Wendan Yu, Manyu Chen, Ruozhu Wang, Wenyang Li, Yan Zuo, Jinjin Pan, Chunyu Hua, Xiaona Lu, Wenhua Fan, Zongheng Zheng, Wuguo Deng, Guangyu Luo, Wei Guo

Mol Oncol. 2021 Apr; 15(4): 1180–1202. Published online 2021 Jan 12. doi: 10.1002/1878-0261.12878

PMCID:: PMC8024721

Article PDF–12M

Select item 38166510.

Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro

Masaki Endoh, Wenyan Zhu, Jun Hasegawa, Hajime Watanabe, Dong-Ki Kim, Masatoshi Aida, Naoto Inukai, Takashi Narita, Tomoko Yamada, Akiko Furuya, Hiroe Sato, Yuki Yamaguchi, Subhrangsu S. Mandal, Danny Reinberg, Tadashi Wada, Hiroshi Handa

Mol Cell Biol. 2004 Apr; 24(8): 3324–3336. doi: 10.1128/MCB.24.8.3324-3336.2004

PMCID:: PMC381665

Article PDF–736K

Select item 346336011.

The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation

Nasim A. Begum, Andre Stanlie, Mikiyo Nakata, Hideo Akiyama, Tasuku Honjo

J Biol Chem. 2012 Sep 21; 287(39): 32415–32429. Published online 2012 Jul 26. doi: 10.1074/jbc.M112.351569

PMCID:: PMC3463360

Article PDF–3.3M

Select item 728710112.

Spt6 is a maintenance factor for centromeric CENP-A

Georg O. M. Bobkov, Anming Huang, Sebastiaan J. W. van den Berg, Sreyoshi Mitra, Eduard Anselm, Vasiliki Lazou, Sarah Schunter, Regina Feederle, Axel Imhof, Alexandra Lusser, Lars E. T. Jansen, Patrick Heun

Nat Commun. 2020; 11: 2919. Published online 2020 Jun 10. doi: 10.1038/s41467-020-16695-7

PMCID:: PMC7287101

Article PDF–3.8M

Select item 363035613.

The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis

A Hongjun Wang, Hossein Zare, Kambiz Mousavi, Chaochen Wang, Cara E Moravec, Howard I Sirotkin, Kai Ge, Gustavo Gutierrez-Cruz, Vittorio Sartorelli

EMBO J. 2013 Apr 17; 32(8): 1075–1086. Published online 2013 Mar 15. doi: 10.1038/emboj.2013.54

PMCID:: PMC3630356

Article PDF–2.1M

Select item 260707514.

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

Sunnie M. Yoh, Joseph S. Lucas, Katherine A. Jones

Genes Dev. 2008 Dec 15; 22(24): 3422–3434. doi: 10.1101/gad.1720008

PMCID:: PMC2607075

Article PDF–677K

Select item 309348715.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation

Il-mi Okazaki, Katsuya Okawa, Maki Kobayashi, Kiyotsugu Yoshikawa, Shimpei Kawamoto, Hitoshi Nagaoka, Reiko Shinkura, Yoko Kitawaki, Hisaaki Taniguchi, Tohru Natsume, Shun-Ichiro Iemura, Tasuku Honjo

Proc Natl Acad Sci U S A. 2011 May 10; 108(19): 7920–7925. Published online 2011 Apr 25. doi: 10.1073/pnas.1104423108

PMCID:: PMC3093487

Article PDF–667K

Select item 363308716.

SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action

Yong-Seok Oh, Pu Gao, Ko-Woon Lee, Ilaria Ceglia, Ji-Seon Seo, Xiaozhu Zhang, Jung-Hyuck Ahn, Brian T. Chait, Dinshaw J. Patel, Yong Kim, Paul Greengard

Cell. Author manuscript; available in PMC 2014 Feb 14.

Published in final edited form as: Cell. 2013 Feb 14; 152(4): 831–843. doi: 10.1016/j.cell.2013.01.014

PMCID:: PMC3633087

Article PDF–3.0M

Select item 177089917.

The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export

Sunnie M. Yoh, Helen Cho, Loni Pickle, Ronald M. Evans, Katherine A. Jones

Genes Dev. 2007 Jan 15; 21(2): 160–174. doi: 10.1101/gad.1503107

PMCID:: PMC1770899

Article PDF–804K

Select item 661480018.

De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair

Jae-Hoon Ji, Sunwoo Min, Sunyoung Chae, Geun-Hyoung Ha, Yonghyeon Kim, Yeon-Ji Park, Chang-Woo Lee, Hyeseong Cho

Nucleic Acids Res. 2019 Jul 9; 47(12): 6299–6314. Published online 2019 May 2. doi: 10.1093/nar/gkz309

PMCID:: PMC6614800

Article PDF–24M

Select item 625867319.

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

Ka-wing Fong, Jonathan C. Zhao, Bing Song, Bin Zheng, Jindan Yu

Nat Commun. 2018; 9: 5007. Published online 2018 Nov 27. doi: 10.1038/s41467-018-07475-5

PMCID:: PMC6258673

Article PDF–3.1M

Select item 988316920.

Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma

Xi-Ya Li, Ji-Chuan Wu, Ping Liu, Zi-Juan Li, Yong Wang, Bing-Yi Chen, Cheng-Long Hu, Ming-Yue Fei, Peng-Cheng Yu, Yi-Lun Jiang, Chun-Hui Xu, Bin-He Chang, Xin-Chi Chen, Li-Juan Zong, Jia-Ying Zhang, Ying Fang, Xiao-Jian Sun, Kai Xue, Li Wang, Shu-Bei Chen, Shi-Yu Jiang, Ai-ling Gui, Ling Yang, Juan J. Gu, Bao-Hua Yu, Qun-ling Zhang, Lan Wang

Leukemia. 2023; 37(1): 164–177. Published online 2022 Nov 9. doi: 10.1038/s41375-022-01747-2