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Select item 102667801.

Human inherited complete STAT2 deficiency underlies inflammatory viral diseases

Giorgia Bucciol, Leen Moens, Masato Ogishi, Darawan Rinchai, Daniela Matuozzo, Mana Momenilandi, Nacim Kerrouche, Catherine M. Cale, Elsa R. Treffeisen, Mohammad Al Salamah, Bandar K. Al-Saud, Alain Lachaux, Remi Duclaux-Loras, Marie Meignien, Aziz Bousfiha, Ibtihal Benhsaien, Anna Shcherbina, Anna Roppelt, COVID Human Genetic Effort, Florian Gothe, Nadhira Houhou-Fidouh, Scott J. Hackett, Lisa M. Bartnikas, Michelle C. Maciag, Mohammed F. Alosaimi, Janet Chou, Reem W. Mohammed, Bishara J. Freij, Emmanuelle Jouanguy, Shen-Ying Zhang, Stephanie Boisson-Dupuis, Vivien Béziat, Qian Zhang, Christopher J.A. Duncan, Sophie Hambleton, Jean-Laurent Casanova, Isabelle Meyts

J Clin Invest. 2023 Jun 15; 133(12): e168321. Published online 2023 Jun 15. doi: 10.1172/JCI168321

PMCID:: PMC10266780

Article PDF–11M

Select item 101460422.

STAT2 act a prognostic biomarker and associated with immune infiltration in kidney renal clear cell carcinoma

Tao Zeng, Jianzhong Ye, Heng Wang, Wen Tian

Medicine (Baltimore) 2023 Apr 25; 102(17): e33662. Published online 2023 Apr 25. doi: 10.1097/MD.0000000000033662

PMCID:: PMC10146042

Article PDF–2.6M

Select item 95270593.

Exposing the Two Contrasting Faces of STAT2 in Inflammation

Philip Duodu, Geohaira Sosa, Jorge Canar, Olivia Chhugani, Ana M. Gamero

J Interferon Cytokine Res. September 2022; 42(9): 467–481. Published online 2022 Sep 15. doi: 10.1089/jir.2022.0117

PMCID:: PMC9527059

Article PDF–587K

Select item 94869784.

Initial activation of STAT2 induced by IAV infection is critical for innate antiviral immunity

Xinxin Li, Siya Liu, Kul Raj Rai, Wenzhuo Zhou, Song Wang, Xiaojuan Chi, Guijie Guo, Ji-Long Chen, Shasha Liu

Front Immunol. 2022; 13: 960544. Published online 2022 Sep 5. doi: 10.3389/fimmu.2022.960544

PMCID:: PMC9486978

Article PDF–6.1M

Select item 87542125.

The Human STAT2 Coiled-Coil Domain Contains a Degron for Zika Virus Interferon Evasion

Jean-Patrick Parisien, Jessica J. Lenoir, Gloria Alvarado, Curt M. Horvath

J Virol. 2022 Jan; 96(1): e01301-21. Prepublished online 2021 Oct 13. Published online 2022 Jan 12. doi: 10.1128/JVI.01301-21

PMCID:: PMC8754212

Article PDF–3.8M

Select item 83901176.

Human Disease Phenotypes Associated with Loss and Gain of Function Mutations in STAT2: Viral Susceptibility and Type I Interferonopathy

Christopher James Arthur Duncan, Sophie Hambleton

J Clin Immunol. 2021; 41(7): 1446–1456. Published online 2021 Aug 26. doi: 10.1007/s10875-021-01118-z

PMCID:: PMC8390117

Article PDF–970K

Select item 79309087.

Life-Threatening Influenza, Hemophagocytic Lymphohistiocytosis and Probable Vaccine-Strain Varicella in a Novel Case of Homozygous STAT2 Deficiency

Bishara J. Freij, Aidan T. Hanrath, Rui Chen, Sophie Hambleton, Christopher J. A. Duncan

Front Immunol. 2020; 11: 624415. Published online 2021 Feb 18. doi: 10.3389/fimmu.2020.624415

PMCID:: PMC7930908

Article PDF–1.3M

Select item 70407548.

STAT2在卵巢癌中表达升高并与卵巢癌患者生存不良有关

陈萱, 黄静莹, 吕育纯

Nan Fang Yi Ke Da Xue Xue Bao. 2020 Jan 20; 40(1): 34–41. Chinese. doi: 10.12122/j.issn.1673-4254.2020.01.06

PMCID:: PMC7040754

Article PDF–1.6M

Select item 66889529.

A novel variant in STAT2 presenting with hemophagocytic lymphohistiocytosis

Mohammed F. Alosaimi, Michelle C. Maciag, Craig D. Platt, Raif S. Geha, Janet Chou, Lisa M. Bartnikas

J Allergy Clin Immunol. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: J Allergy Clin Immunol. 2019 Aug; 144(2): 611–613.e3. Published online 2019 May 15. doi: 10.1016/j.jaci.2019.05.008

PMCID:: PMC6688952

Article PDF–475K

Select item 523999410.

Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387

Yuxin Wang, Jing Nan, Belinda Willard, Xin Wang, Jinbo Yang, George R Stark

EMBO J. 2017 Jan 17; 36(2): 202–212. Published online 2016 Nov 16. doi: 10.15252/embj.201694834

PMCID:: PMC5239994

Article PDF–1.3M

Select item 341554411.

A Haplotype at STAT2 Introgressed from Neanderthals and Serves as a Candidate of Positive Selection in Papua New Guinea

Fernando L. Mendez, Joseph C. Watkins, Michael F. Hammer

Am J Hum Genet. 2012 Aug 10; 91(2): 265–274. doi: 10.1016/j.ajhg.2012.06.015

PMCID:: PMC3415544

Article PDF–682K

Select item 339823412.

HSV-2 inhibits type I interferon signaling via multiple complementary and compensatory STAT2-associated mechanisms

Ravi-Kumar Kadeppagari, Rebecca L. Sanchez, Timothy P. Foster

Virus Res. Author manuscript; available in PMC 2013 Aug 1.

Published in final edited form as: Virus Res. 2012 Aug; 167(2): 273–284. Published online 2012 May 23. doi: 10.1016/j.virusres.2012.05.010

PMCID:: PMC3398234

Article PDF–4.3M

Select item 312150213.

Chromatin Dynamics of Gene Activation and Repression in Response to Interferon α (IFNα) Reveal New Roles for Phosphorylated and Unphosphorylated Forms of the Transcription Factor STAT2

Barbara Testoni, Christine Völlenkle, Francesca Guerrieri, Sabine Gerbal-Chaloin, Giovanni Blandino, Massimo Levrero

J Biol Chem. 2011 Jun 10; 286(23): 20217–20227. Published online 2011 Apr 15. doi: 10.1074/jbc.M111.231068

PMCID:: PMC3121502

Article PDF–1.8M

Select item 280846014.

Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2

Ana L. Romero-Weaver, Hsiang-Wen Wang, Håkan C. Steen, Anthony J. Scarzello, Veronica L. Hall, Faruk Sheikh, Raymond P. Donnelly, Ana M. Gamero

Mol Cancer Res. Author manuscript; available in PMC 2011 Jan 12.

Published in final edited form as: Mol Cancer Res. 2010 Jan; 8(1): 80–92. Published online 2010 Jan 12. doi: 10.1158/1541-7786.MCR-08-0344

PMCID:: PMC2808460

Article PDF–422K

Select item 268197315.

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

Joseph Ashour, Maudry Laurent-Rolle, Pei-Yong Shi, Adolfo García-Sastre

J Virol. 2009 Jun; 83(11): 5408–5418. Published online 2009 Mar 11. doi: 10.1128/JVI.02188-08

PMCID:: PMC2681973

Article PDF–2.0M

Select item 251963116.

STAT2 Is a Primary Target for Measles Virus V Protein-Mediated Alpha/Beta Interferon Signaling Inhibition

Aparna Ramachandran, Jean-Patrick Parisien, Curt M. Horvath

J Virol. 2008 Sep; 82(17): 8330–8338. Published online 2008 Jun 25. doi: 10.1128/JVI.00831-08

PMCID:: PMC2519631

Article PDF–2.2M

Select item 14951817.

The STAT2 Activation Process Is a Crucial Target of Sendai Virus C Protein for the Blockade of Alpha Interferon Signaling

Bin Gotoh, Kenji Takeuchi, Takayuki Komatsu, Junko Yokoo

J Virol. 2003 Mar; 77(6): 3360–3370. doi: 10.1128/JVI.77.6.3360-3370.2003

PMCID:: PMC149518

Article PDF–2.5M

Select item 13624818.

STAT2 Acts as a Host Range Determinant for Species-Specific Paramyxovirus Interferon Antagonism and Simian Virus 5 Replication

Jean-Patrick Parisien, Joe F. Lau, Curt M. Horvath

J Virol. 2002 Jul; 76(13): 6435–6441. doi: 10.1128/JVI.76.13.6435-6441.2002

PMCID:: PMC136248

Article PDF–798K

Select item 4980719.

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

X Y Fu, C Schindler, T Improta, R Aebersold, J E Darnell, Jr

Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16): 7840–7843. doi: 10.1073/pnas.89.16.7840

PMCID:: PMC49807

Summary Page Browse PDF–1.3M

Select item 1011067620.

Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2

Gaofeng Zhu, Mihaly Badonyi, Lina Franklin, Luis Seabra, Gillian I. Rice, Anne-Boland-Auge, Jean-François Deleuze, Salima El-Chehadeh, Mathieu Anheim, Anne de Saint-Martin, Sandra Pellegrini, Joseph A. Marsh, Yanick J. Crow, Marie-Therese El-Daher

J Clin Immunol. 2023; 43(4): 808–818. Published online 2023 Feb 8. doi: 10.1007/s10875-023-01445-3

PMCID:: PMC10110676

Article PDF–1.3M

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