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Select item 96327591.

Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL

Kensuke Sasaki, Takuji Yamauchi, Yuichiro Semba, Jumpei Nogami, Hiroshi Imanaga, Tatsuya Terasaki, Fumihiko Nakao, Koshi Akahane, Takeshi Inukai, Els Verhoeyen, Koichi Akashi, Takahiro Maeda

Blood. 2022 Feb 3; 139(5): 748–760. doi: 10.1182/blood.2021012976

PMCID:: PMC9632759

Abstract Article

Select item 82886562.

Increased prevalence of CRLF2 rearrangements in obesity-associated acute lymphoblastic leukemia

Steven D. Mittelman, Jiyoon Kim, Gordana Raca, Gang Li, Matthew J. Oberley, Etan Orgel

Blood. 2021 Jul 15; 138(2): 199–202. Prepublished online 2021 Apr 19. doi: 10.1182/blood.2021011106

PMCID:: PMC8288656

Article

Select item 69077663.

Clinical characterization and prognosis of T cell acute lymphoblastic leukemia with high CRLF2 gene expression in children

Mingmin Wang, Jinquan Wen, Yuxia Guo, Yali Shen, Xizhou An, Yanni Hu, Jianwen Xiao

PLoS One. 2019; 14(12): e0224652. Published online 2019 Dec 12. doi: 10.1371/journal.pone.0224652

PMCID:: PMC6907766

Abstract Article PDF–769K

Select item 66389744.

CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition

Lauren K. Meyer, Cristina Delgado-Martin, Shannon L. Maude, Kevin M. Shannon, David T. Teachey, Michelle L. Hermiston

PLoS One. 2019; 14(7): e0220026. Published online 2019 Jul 18. doi: 10.1371/journal.pone.0220026

PMCID:: PMC6638974

Abstract Article PDF–923K

Select item 63985885.

Single cell analysis identifies CRLF2 rearrangements as both early and late events in Down syndrome and non-Down syndrome acute lymphoblastic leukaemia

N Potter, L Jones, H Blair, S Strehl, CJ Harrison, M Greaves, L Kearney, LJ Russell

Leukemia. Author manuscript; available in PMC 2019 May 28.

Published in final edited form as: Leukemia. 2019 Apr; 33(4): 893–904. Published online 2018 Nov 28. doi: 10.1038/s41375-018-0297-4

PMCID:: PMC6398588

Abstract Article PDF–1.1M

Select item 63129596.

Potential efficacy and prognosis of silencing the CRLF2-mediated AKT/mTOR pathway in pediatric acute B-cell lymphoblastic leukemia

Min Jiang, Xueqin Zou, Lingyun Lu

Oncol Rep. 2019 Feb; 41(2): 885–894. Published online 2018 Dec 7. doi: 10.3892/or.2018.6917

PMCID:: PMC6312959

Abstract Article PDF–806K

Select item 57732787.

t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH translocations from human B-lineage ALLs involve CpG-type breaks at CRLF2, but CRLF2/P2RY8 intrachromosomal deletions do not

Albert G. Tsai, Akinori Yoda, David M. Weinstock, Michael R. Lieber

Blood. 2010 Sep 16; 116(11): 1993–1994. doi: 10.1182/blood-2010-05-286492

PMCID:: PMC5773278

Article

Select item 53123108.

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia

Chiara Palmi, Angela M. Savino, Daniela Silvestri, Ilaria Bronzini, Gunnar Cario, Maddalena Paganin, Barbara Buldini, Marta Galbiati, Martina U. Muckenthaler, Cristina Bugarin, Pamela Della Mina, Stefan Nagel, Elena Barisone, Fiorina Casale, Franco Locatelli, Luca Lo Nigro, Concetta Micalizzi, Rosanna Parasole, Andrea Pession, Maria C. Putti, Nicola Santoro, Anna M. Testi, Ottavio Ziino, Andreas E. Kulozik, Martin Zimmermann, Martin Schrappe, Antonello Villa, Giuseppe Gaipa, Giuseppe Basso, Andrea Biondi, Maria G. Valsecchi, Martin Stanulla, Valentino Conter, Geertruy te Kronnie, Giovanni Cazzaniga

Oncotarget. 2016 Sep 13; 7(37): 59260–59272. Published online 2016 Jul 15. doi: 10.18632/oncotarget.10610

PMCID:: PMC5312310

Abstract Article PDF–2.7M

Select item 44043109.

Understanding the Biology of CRLF2-Overexpressing Acute Lymphoblastic Leukemia

Sarah K. Tasian, Mignon L. Loh

Crit Rev Oncog. Author manuscript; available in PMC 2015 Apr 20.

Published in final edited form as: Crit Rev Oncog. 2011; 16(0): 13–24. doi: 10.1615/critrevoncog.v16.i1-2.30

PMCID:: PMC4404310

Abstract Article PDF–483K

Select item 346696610.

Differences in signaling through the B-cell leukemia oncoprotein CRLF2 in response to TSLP and through mutant JAK2

Diederik van Bodegom, Jun Zhong, Nadja Kopp, Chaitali Dutta, Min-Sik Kim, Liat Bird, Oliver Weigert, Jeffrey Tyner, Akhilesh Pandey, Akinori Yoda, David M. Weinstock

Blood. 2012 Oct 4; 120(14): 2853–2863. Prepublished online 2012 Aug 20. doi: 10.1182/blood-2012-02-413252

PMCID:: PMC3466966

Abstract Article

Select item 280678211.

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

Akinori Yoda, Yuka Yoda, Sabina Chiaretti, Michal Bar-Natan, Kartik Mani, Scott J. Rodig, Nathan West, Yun Xiao, Jennifer R. Brown, Constantine Mitsiades, Martin Sattler, Jeffrey L. Kutok, Daniel J. DeAngelo, Martha Wadleigh, Alfonso Piciocchi, Paola Dal Cin, James E. Bradner, James D. Griffin, Kenneth C. Anderson, Richard M. Stone, Jerome Ritz, Robin Foà, Jon C. Aster, David A. Frank, David M. Weinstock

Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1): 252–257. Published online 2009 Dec 29. doi: 10.1073/pnas.0911726107

PMCID:: PMC2806782

Abstract Article PDF–924K

Select item 278381012.

REARRANGEMENT OF CRLF2 IN B-PROGENITOR AND DOWN SYNDROME ASSOCIATED ACUTE LYMPHOBLASTIC LEUKEMIA

Charles G. Mullighan, J Racquel Collins-Underwood, Letha A.A. Phillips, Michael L. Loudin, Wei Liu, Jinghui Zhang, Jing Ma, Elaine Coustan-Smith, Richard C. Harvey, Cheryl L. Willman, Fady M. Mikhail, Julia Meyer, Andrew J. Carroll, Richard T. Williams, Jinjun Cheng, Nyla A. Heerema, Giuseppe Basso, Andrea Pession, Ching-Hon Pui, Susana C. Raimondi, Stephen P. Hunger, James R. Downing, William L. Carroll, Karen R. Rabin

Nat Genet. Author manuscript; available in PMC 2010 May 1.

Published in final edited form as: Nat Genet. 2009 Nov; 41(11): 1243–1246. Published online 2009 Oct 18. doi: 10.1038/ng.469

PMCID:: PMC2783810

Abstract Article PDF–1.5M

Select item 913322813.

CRLF2 overexpression results in reduced B cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome

Jacob J. Junco, Barry Zorman, Vincent U. Gant, Jr., Jaime Muñoz, H. Daniel Lacorazza, Pavel Sumazin, Karen R. Rabin

Exp Hematol. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Exp Hematol. 2022 Jun; 110: 34–38. Published online 2022 Mar 17. doi: 10.1016/j.exphem.2022.03.005

PMCID:: PMC9133228

Abstract Article PDF–481K

Select item 522654214.

High CRLF2 expression associates with IKZF1 dysfunction in adult acute lymphoblastic leukemia without CRLF2 rearrangement

Zheng Ge, Yan Gu, Gang Zhao, Jianyong Li, Baoan Chen, Qi Han, Xing Guo, Juan Liu, Hui Li, Michael D. Yu, Justin Olson, Sadie Steffens, Kimberly J. Payne, Chunhua Song, Sinisa Dovat

Oncotarget. 2016 Aug 2; 7(31): 49722–49732. Published online 2016 Jul 6. doi: 10.18632/oncotarget.10437

PMCID:: PMC5226542

Abstract Article PDF–5.5M

Select item 419431415.

Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2–harboring clones as main relapse-driving force in childhood ALL

Maria Morak, Andishe Attarbaschi, Susanna Fischer, Christine Nassimbeni, Reinhard Grausenburger, Stephan Bastelberger, Stefanie Krentz, Gunnar Cario, David Kasper, Klaus Schmitt, Lisa J. Russell, Ulrike Pötschger, Martin Stanulla, Conny Eckert, Georg Mann, Oskar A. Haas, Renate Panzer-Grümayer

Blood. Author manuscript; available in PMC 2014 Oct 13.

Published in final edited form as: Blood. 2012 Dec 20; 120(26): 5134–5142. Published online 2012 Oct 22. doi: 10.1182/blood-2012-07-443218

Correction in:: Blood, volume 122 on page 1328

PMCID:: PMC4194314

Abstract Article PDF–1012K

Select item 294859616.

CRLF2 and JAK2 in B-Progenitor Acute Lymphoblastic Leukemia: A Novel Association in Oncogenesis

J. Devon Roll, Gary W. Reuther

Cancer Res. Author manuscript; available in PMC 2011 Oct 1.

Published in final edited form as: Cancer Res. 2010 Oct 1; 70(19): 7347–7352. Published online 2010 Aug 31. doi: 10.1158/0008-5472.CAN-10-1528

PMCID:: PMC2948596

Abstract Article PDF–485K

Select item 281445217.

Targeting Allergen to FcγRI Reveals a Novel Th2 Regulatory Pathway Linked to TSLP Receptor

Kathryn E. Hulse, Amanda J. Reefer, Victor H. Engelhard, James T. Patrie, Steven F. Ziegler, Martin D. Chapman, Judith A. Woodfolk

J Allergy Clin Immunol. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: J Allergy Clin Immunol. 2010 Jan; 125(1): 247. doi: 10.1016/j.jaci.2009.10.027

PMCID:: PMC2814452

Abstract Article PDF–2.2M

Select item 846961318.

Expression and Polymorphism of TSLP/TSLP Receptors as Potential Diagnostic Markers of Colorectal Cancer Progression

Abdelhabib Semlali, Mikhlid H. Almutairi, Abdullah Alamri, Narasimha Reddy Parine, Maha Arafah, Majid A. Almadi, Abdulrahman M. Aljebreen, Othman Alharbi, Nahla Ali Azzam, Riyadh Almutairi, Mohammad Alanazi, Mahmoud Rouabhia

Genes (Basel) 2021 Sep; 12(9): 1386. Published online 2021 Sep 6. doi: 10.3390/genes12091386

PMCID:: PMC8469613

Abstract Article PDF–1.9M

Select item 668764519.

TSLP and TSLP receptors variants are associated with smoking

Abdelhabib Semlali, Mikhlid Almutairi, Arezki Azzi, Narasimha Reddy Parine, Abdullah AlAmri, Saleh Alsulami, Talal Meshal Alumri, Mohammad Saud Alanazi, Mahmoud Rouabhia

Mol Genet Genomic Med. 2019 Aug; 7(8): e842. Published online 2019 Jul 9. doi: 10.1002/mgg3.842

PMCID:: PMC6687645

Abstract Article PDF–890K

Select item 608543220.

Genetic Regulation of the Thymic Stromal Lymphopoietin (TSLP)/TSLP Receptor (TSLPR) Gene Expression and Influence of Epistatic Interactions Between IL-33 and the TSLP/TSLPR Axis on Risk of Coronary Artery Disease

Shao-Fang Nie, Ling-Feng Zha, Qian Fan, Yu-Hua Liao, Hong-Song Zhang, Qian-Wen Chen, Fan Wang, Ting-Ting Tang, Ni Xia, Cheng-Qi Xu, Jiao-Yue Zhang, Yu-Zhi Lu, Zhi-Peng Zeng, Jiao Jiao, Yuan-Yuan Li, Tian Xie, Wen-Juan Zhang, Dan Wang, Chu-Chu Wang, Jing-Jing Fa, Hong-Bo Xiong, Jian Ye, Qing Yang, Peng-Yun Wang, Sheng-Hua Tian, Qiu-Lun Lv, Qing-Xian Li, Jin Qian, Bin Li, Gang Wu, Yan-Xia Wu, Yan Yang, Xiang-Ping Yang, Yu Hu, Qing K. Wang, Xiang Cheng, Xin Tu

Front Immunol. 2018; 9: 1775. Published online 2018 Aug 3. doi: 10.3389/fimmu.2018.01775

PMCID:: PMC6085432

Abstract Article PDF–1.0M

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