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Select item 100197541.

RRM1 is mediated by histone acetylation through gemcitabine resistance and contributes to invasiveness and ECM remodeling in pancreatic cancer

Hiroaki Ono, Yoshiki Murase, Hironari Yamashita, Tomotaka Kato, Daisuke Asano, Yoshiya Ishikawa, Shuichi Watanabe, Hiroki Ueda, Keiichi Akahoshi, Kosuke Ogawa, Atsushi Kudo, Yoshimitsu Akiyama, Shinji Tanaka, Minoru Tanabe

Int J Oncol. 2023 Apr; 62(4): 51. Published online 2023 Mar 2. doi: 10.3892/ijo.2023.5499

PMCID:: PMC10019754

Article PDF–7.5M

Select item 81918852.

Cytoplasmic RRM1 activation as an acute response to gemcitabine treatment is involved in drug resistance of pancreatic cancer cells

Tomotaka Kato, Hiroaki Ono, Mikiya Fujii, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe

PLoS One. 2021; 16(6): e0252917. Published online 2021 Jun 10. doi: 10.1371/journal.pone.0252917

PMCID:: PMC8191885

Article PDF–1.9M

Select item 80714143.

Knockdown of RRM1 with Adenoviral shRNA Vectors to Inhibit Tumor Cell Viability and Increase Chemotherapeutic Sensitivity to Gemcitabine in Bladder Cancer Cells

Xia Zhang, Rikiya Taoka, Dage Liu, Yuki Matsuoka, Yoichiro Tohi, Yoshiyuki Kakehi, Mikio Sugimoto

Int J Mol Sci. 2021 Apr; 22(8): 4102. Published online 2021 Apr 15. doi: 10.3390/ijms22084102

PMCID:: PMC8071414

Article PDF–2.3M

Select item 69045824.

WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

Lilit Nersisyan, Maria Nikoghosyan, The Genome of the Netherlands consortium, Arsen Arakelyan

Sci Rep. 2019; 9: 18758. Published online 2019 Dec 10. doi: 10.1038/s41598-019-55109-7

PMCID:: PMC6904582

Article PDF–1.3M

Select item 68074655.

Association of Novel Gene Polymorphisms RRM1 −756T>C and −269 C>A With Breast Cancer

Dar‐Ren Chen, Chun‐Yi Chuang, Buor‐Chang Wu, Shun‐Fa Yang, Yu‐Hsien Peng, Hsiu‐Ting Tsai

J Clin Lab Anal. 2014 Jul; 28(4): 287–293. Published online 2014 Feb 27. doi: 10.1002/jcla.21682

PMCID:: PMC6807465

Article PDF–89K

Select item 66571366.

RRM1 predicts clinical outcome of high-and intermediate-risk non-muscle-invasive bladder cancer patients treated with intravesical gemcitabine monotherapy

Zhenxing Yang, Bingqiang Fu, Luqiang Zhou, Jie Xu, Ping Hao, Zhenqiang Fang

BMC Urol. 2019; 19: 69. Published online 2019 Jul 24. doi: 10.1186/s12894-019-0497-x

PMCID:: PMC6657136

Article PDF–586K

Select item 55816717.

Ribonucleotide reductase large subunit (RRM1) as a novel therapeutic target in multiple myeloma

Morihiko Sagawa, Hiroto Ohguchi, Takeshi Harada, Mehmet K. Samur, Yu-Tzu Tai, Nikhil C. Munshi, Masahiro Kizaki, Teru Hideshima, Kenneth C. Anderson

Clin Cancer Res. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Clin Cancer Res. 2017 Sep 1; 23(17): 5225–5237. Published online 2017 Apr 25. doi: 10.1158/1078-0432.CCR-17-0263

PMCID:: PMC5581671

Article PDF–2.4M

Select item 49952368.

The relationship between RRM1 gene polymorphisms and effectiveness of gemcitabine-based first-line chemotherapy in advanced NSCLC patient

R. Mlak, P. Krawczyk, M. Ciesielka, P. Kozioł, I. Homa, T. Powrózek, M. Prendecka, J. Milanowski, T. Małecka-Massalska

Clin Transl Oncol. 2016; 18(9): 915–924. Published online 2015 Dec 9. doi: 10.1007/s12094-015-1461-1

PMCID:: PMC4995236

Article PDF–513K

Select item 42715439.

A Fluorimetric Readout Reporting the Kinetics of Nucleotide-Induced Human Ribonucleotide Reductase Oligomerization

Yuan Fu, Hongyu Lin, Somsinee Wisitpitthaya, William A. Blessing, Yimon Aye

Chembiochem. Author manuscript; available in PMC 2015 Nov 24.

Published in final edited form as: Chembiochem. 2014 Nov 24; 15(17): 2598–2604. Published online 2014 Sep 24. doi: 10.1002/cbic.201402368

PMCID:: PMC4271543

Article PDF–2.4M

Select item 392557810.

First-Line Gemcitabine Plus Cisplatin in Nonsmall Cell Lung Cancer Patients

Ying Li, Lin Run Wang, Jian Chen, Yan Lou, Guo Bing Zhang

Dis Markers. 2014; 2014: 960458. Published online 2014 Jan 23. doi: 10.1155/2014/960458

PMCID:: PMC3925578

Article PDF–807K

Select item 372637311.

Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer

Qinchuan Wang, Xiyong Liu, Jichun Zhou, Yasheng Huang, Shengjie Zhang, Jianguo Shen, Sofia Loera, Xiaoming Yuan, Wenjun Chen, Mei Jin, Stephen Shibata, Yingbin Liu, Peiguo Chu, Linbo Wang, Yun Yen

PLoS One. 2013; 8(7): e70191. Published online 2013 Jul 29. doi: 10.1371/journal.pone.0070191

PMCID:: PMC3726373

Article PDF–1.9M

Select item 304893112.

RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum

Lin-run Wang, Guo-bing Zhang, Jian Chen, Jun Li, Ming-wei Li, Nong Xu, Yang Wang, Jian-zhong Shentu

J Zhejiang Univ Sci B. 2011 Mar; 12(3): 174–179. doi: 10.1631/jzus.B1000197

PMCID:: PMC3048931

Article PDF–106K

Select item 285551313.

RRM1 single nucleotide polymorphism -37C→A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy

Song Dong, Ai-Lin Guo, Zhi-Hong Chen, Zhen Wang, Xu-Chao Zhang, Ying Huang, Zhi Xie, Hong-Hong Yan, Hua Cheng, Yi-Long Wu

J Hematol Oncol. 2010; 3: 10. Published online 2010 Mar 13. doi: 10.1186/1756-8722-3-10

PMCID:: PMC2855513

Article PDF–1015K

Select item 32840614.

Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes.

N J Parker, C G Begley, R M Fox

Nucleic Acids Res. 1991 Jul 11; 19(13): 3741. doi: 10.1093/nar/19.13.3741

PMCID:: PMC328406

Summary Page Browse PDF–189K

Select item 885703315.

Targeting ribonucleotide reductase induces synthetic lethality in PP2A-deficient uterine serous carcinoma

Caitlin M. O’Connor, Sarah E. Taylor, Kathryn M. Miller, Lauren Hurst, Terrance J. Haanen, Tahra K. Suhan, Kaitlin P. Zawacki, Fallon K. Noto, Jonida Trako, Arathi Mohan, Jaya Sangodkar, Dmitriy Zamarin, Analisa DiFeo, Goutham Narla

Cancer Res. Author manuscript; available in PMC 2022 Aug 15.

Published in final edited form as: Cancer Res. 2022 Feb 15; 82(4): 721–733. doi: 10.1158/0008-5472.CAN-21-1987

PMCID:: PMC8857033

Article PDF–2.3M

Select item 834044516.

RRM1 and ERCC1 as biomarkers in patients with locally advanced and metastatic malignant pleural mesothelioma treated with continuous infusion of low-dose gemcitabine plus cisplatin

Wendy Muñoz-Montaño, Sae Muñiz-Hernández, Alejandro Avilés-Salas, Rodrigo Catalán, Luis Lara-Mejía, Suraj Samtani-Bassarmal, Andres F. Cardona, Jorge Mendoza-Desión, Daniel Hernández-Cueto, Altagracia Maldonado, Guillermina Baay-Guzmán, Sara Huerta-Yepes, Oscar Arrieta

BMC Cancer. 2021; 21: 892. Published online 2021 Aug 5. doi: 10.1186/s12885-021-08287-5

PMCID:: PMC8340445

Article PDF–1.2M

Select item 686314617.

RRM1, ERCC1 and TS1 Immunofluorescence Expression in Leiomyosarcoma: A Tissue Microarray Study with Clinical Outcome Correlation Analysis

Sam D. Zheng, Katherine Bui, Alberto Chiappori, Gerold Bepler, Marilyn M. Bui

Pathol Oncol Res. Author manuscript; available in PMC 2019 Nov 19.

Published in final edited form as: Pathol Oncol Res. 2016 Jul; 22(3): 477–482. Published online 2015 Nov 26. doi: 10.1007/s12253-015-0021-x

PMCID:: PMC6863146

Article PDF–688K

Select item 624575018.

Tumor-based gene expression biomarkers to predict survival following curative intent resection for stage I lung adenocarcinoma

Alisson Clemenceau, Nathalie Gaudreault, Cyndi Henry, Paula A. Ugalde, Catherine Labbé, Michel Laviolette, Philippe Joubert, Yohan Bossé

PLoS One. 2018; 13(11): e0207513. Published online 2018 Nov 20. doi: 10.1371/journal.pone.0207513

PMCID:: PMC6245750

Article PDF–1.5M

Select item 617153019.

Nuclear RNR-α Antagonizes Cell Proliferation by Directly Inhibiting ZRANB3

Yuan Fu, Marcus J. C. Long, Somsinee Wisitpitthaya, Huma Inayat, Timothy M. Pierpont, Islam M. Elsaid, Jordana C. Bloom, Joaquin Ortega, Robert S. Weiss, Yimon Aye

Nat Chem Biol. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Nat Chem Biol. 2018 Oct; 14(10): 943–954. Published online 2018 Aug 27. doi: 10.1038/s41589-018-0113-5

PMCID:: PMC6171530

Article PDF–1.2M

Select item 545409720.

Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy

Meng Lou, Qian Liu, Guoping Ren, Jiling Zeng, Xueping Xiang, Yongfeng Ding, Qinghui Lin, Tingting Zhong, Xia Liu, Lijun Zhu, Hongyan Qi, Jing Shen, Haoran Li, Jimin Shao

J Biol Chem. 2017 Jun 2; 292(22): 9136–9149. Published online 2017 Apr 14. doi: 10.1074/jbc.M117.783365