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Select item 92950711.

Smoke-induced SAV1 Gene Promoter Hypermethylation Disrupts YAP Negative Feedback and Promotes Malignant Progression of Non-small Cell Lung Cancer

Ting Liu, Wei Guo, Kai Luo, Lei Li, Jing Dong, Meijun Liu, Xingyuan Shi, Zhiyuan Wang, Jianlei Zhang, Jiang Yin, Ni Qiu, Minying Lu, Danyang Chen, Xiaoting Jia, Hao Liu, Yixue Gu, Yan Xiong, Guopei Zheng, Gang Xu, Zhimin He, Zhijie Zhang

Int J Biol Sci. 2022; 18(11): 4497–4512. Published online 2022 Jul 11. doi: 10.7150/ijbs.73428

PMCID:: PMC9295071

Article PDF–3.2M

Select item 65290882.

SAV1 represses the development of human colorectal cancer by regulating the Akt‐mTOR pathway in a YAP‐dependent manner

Jianwu Jiang, Wei Chang, Yang Fu, Yongshun Gao, Chunlin Zhao, Xiefu Zhang, Shuijun Zhang

Cell Prolif. 2017 Aug; 50(4): e12351. Published online 2017 Jun 15. doi: 10.1111/cpr.12351

PMCID:: PMC6529088

Article PDF–967K

Select item 53566043.

WW45, a Gli1 binding protein, negatively regulated Hedgehog signaling in lung cancer

Xuebing Li, Xuexia Zhou, Yaguang Fan, Yalong Zhang, Lingling Zu, Feng Yao, Qinghua Zhou

Oncotarget. 2016 Oct 18; 7(42): 68966–68975. Published online 2016 Sep 21. doi: 10.18632/oncotarget.12155

PMCID:: PMC5356604

Article PDF–7.5M

Select item 32925164.

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma

Keiko Matsuura, Chisato Nakada, Mizuho Mashio, Takahiro Narimatsu, Taichiro Yoshimoto, Masato Tanigawa, Yoshiyuki Tsukamoto, Naoki Hijiya, Ichiro Takeuchi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masao Seto, Masatsugu Moriyama

BMC Cancer. 2011; 11: 523. Published online 2011 Dec 20. doi: 10.1186/1471-2407-11-523

PMCID:: PMC3292516

Article PDF–1.4M

Select item 89904825.

ALKBH5 Promotes Multiple Myeloma Tumorigenicity through inducing m⁶A-demethylation of SAV1 mRNA and Myeloma Stem Cell Phenotype

Tingting Yu, Lan Yao, Hua Yin, Yao Teng, Mei Hong, Qiuling Wu

Int J Biol Sci. 2022; 18(6): 2235–2248. Published online 2022 Mar 6. doi: 10.7150/ijbs.64943

PMCID:: PMC8990482

Article PDF–2.8M

Select item 30996656.

Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions

Howard Donninger, Nadia Allen, Adrianna Henson, Jennifer Pogue, Andrew Williams, Laura Gordon, Susannah Kassler, Thomas Dunwell, Farida Latif, Geoffrey J. Clark

J Biol Chem. 2011 May 27; 286(21): 18483–18491. Published online 2011 Apr 13. doi: 10.1074/jbc.M110.214874

PMCID:: PMC3099665

Article PDF–1.2M

Select item 88544067.

Cell adhesion molecule KIRREL1 is a feedback regulator of Hippo signaling recruiting SAV1 to cell-cell contact sites

Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong

Nat Commun. 2022; 13: 930. Published online 2022 Feb 17. doi: 10.1038/s41467-022-28567-3

PMCID:: PMC8854406

Article PDF–3.9M

Select item 64475408.

MERTK mediated novel site Akt phosphorylation alleviates SAV1 suppression

Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu

Nat Commun. 2019; 10: 1515. Published online 2019 Apr 3. doi: 10.1038/s41467-019-09233-7

PMCID:: PMC6447540

Article PDF–1.8M

Select item 28516279.

The human WW45 protein enhances MST1-mediated apoptosis in vivo

Xuelai Luo, Zhaoming Li, Qun Yan, Xiaolan Li, Deding Tao, Jing Wang, Yan Leng, Kevin Gardner, Susan I.V. Judge, Qingdi Q. Li, Junbo Hu, Jianping Gong

Int J Mol Med. Author manuscript; available in PMC 2010 Apr 8.

Published in final edited form as: Int J Mol Med. 2009 Mar; 23(3): 357–362.

PMCID:: PMC2851627

Article PDF–616K

Select item 590076710.

Salvador has an extended SARAH domain that mediates binding to Hippo kinase

Leah Cairns, Thao Tran, Brendan H. Fowl, Angela Patterson, Yoo Jin Kim, Brian Bothner, Jennifer M. Kavran

J Biol Chem. 2018 Apr 13; 293(15): 5532–5543. Published online 2018 Mar 8. doi: 10.1074/jbc.RA117.000923

PMCID:: PMC5900767

Article PDF–1.7M

Select item 566347511.

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK

Sung Jun Bae, Lisheng Ni, Adam Osinski, Diana R Tomchick, Chad A Brautigam, Xuelian Luo

eLife. 2017; 6: e30278. Published online 2017 Oct 24. doi: 10.7554/eLife.30278

PMCID:: PMC5663475

Article PDF–4.3M

Select item 393935612.

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

Balca R. Mardin, Cornelia Lange, Joanne E. Baxter, Tara Hardy, Andrew M. Fry, Elmar Schiebel

Nat Cell Biol. Author manuscript; available in PMC 2014 Mar 3.

Published in final edited form as: Nat Cell Biol. 2010 Dec; 12(12): 1166–1176. Published online 2010 Nov 14. doi: 10.1038/ncb2120

PMCID:: PMC3939356

Article PDF–5.5M

Select item 189047813.

Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway

Eunha Hwang, Kyoung-Seok Ryu, Kimmo Pääkkönen, Peter Güntert, Hae-Kap Cheong, Dae-Sik Lim, Jie-Oh Lee, Young Ho Jeon, Chaejoon Cheong

Proc Natl Acad Sci U S A. 2007 May 29; 104(22): 9236–9241. Published online 2007 May 21. doi: 10.1073/pnas.0610716104

PMCID:: PMC1890478

Article PDF–848K

Select item 625434614.

Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling

Sebastian Mana-Capelli, Dannel McCollum

J Biol Chem. 2018 Nov 23; 293(47): 18230–18241. Published online 2018 Sep 28. doi: 10.1074/jbc.RA118.004187

PMCID:: PMC6254346

Article PDF–2.4M

Select item 837278415.

AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation

Daehee Hwang, Miju Kim, Soyeon Kim, Mi Ra Kwon, Ye-Seul Kang, Dahyun Kim, Ho-Chul Kang, Dae-Sik Lim

Life Sci Alliance. 2021 Oct; 4(10): e202000953. Published online 2021 Aug 17. doi: 10.26508/lsa.202000953

PMCID:: PMC8372784

Article PDF–2.7M

Select item 794904716.

CORO7 functions as a scaffold protein for the core kinase complex assembly of the Hippo pathway

Jina Park, Kyoungho Jun, Yujin Choi, Eunju Yoon, Wonho Kim, Yoon-Gu Jang, Jongkyeong Chung

J Biol Chem. 2021 Jan-Jun; 296: 100040. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.013297

PMCID:: PMC7949047

Article PDF–3.4M

Select item 360569317.

The Tumor Suppressor Mst1 Promotes Changes in the Cellular Redox State by Phosphorylation and Inactivation of Peroxiredoxin-1 Protein

Sonali Jalan Rawat, Caretha L. Creasy, Jeffrey R. Peterson, Jonathan Chernoff

J Biol Chem. 2013 Mar 22; 288(12): 8762–8771. Published online 2013 Feb 5. doi: 10.1074/jbc.M112.414524

PMCID:: PMC3605693

Article PDF–1.6M

Select item 295673218.

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences

Undraga Schagdarsurengin, Antje M Richter, Juliane Hornung, Cornelia Lange, Katrin Steinmann, Reinhard H Dammann

Mol Cancer. 2010; 9: 264. Published online 2010 Sep 29. doi: 10.1186/1476-4598-9-264

PMCID:: PMC2956732

Article PDF–3.0M

Select item 441847819.

A genome-wide association meta-analysis of plasma Aß peptides concentrations in the elderly

V Chouraki, RFAG De Bruijn, J Chapuis, JC Bis, C Reitz, S Schraen, CA Ibrahim-Verbaas, B Grenier-Boley, C Delay, R Rogers, F Demiautte, A Mounier, AL Fitzpatrick, The Alzheimer’s Disease Neuroimaging Initiative, C Berr, J-F Dartigues, AG Uitterlinden, A Hofman, M Breteler, JT Becker, M Lathrop, N Schupf, A Alpérovitch, R Mayeux, CM van Duijn, L Buée, P Amouyel, OL Lopez, MA Ikram, C Tzourio, J-C Lambert

Mol Psychiatry. Author manuscript; available in PMC 2015 May 4.

Published in final edited form as: Mol Psychiatry. 2014 Dec; 19(12): 1326–1335. Published online 2014 Feb 18. doi: 10.1038/mp.2013.185

PMCID:: PMC4418478

Article PDF–1.0M

Select item 285539720.

Ajuba LIM Proteins are Negative Regulators of the Hippo Signaling Pathway

Meghna Das Thakur, Yunfeng Feng, Radhika Jagannathan, Midori J. Seppa, James B. Skeath, Gregory D. Longmore

Curr Biol. Author manuscript; available in PMC 2011 Apr 13.

Published in final edited form as: Curr Biol. 2010 Apr 13; 20(7): 657–662. Published online 2010 Mar 18. doi: 10.1016/j.cub.2010.02.035

PMCID:: PMC2855397

Article PDF–4.3M

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