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Select item 99364571.

Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma

Gentao Fan, Yan Zhu, Hao Zhu, Lingfeng Yu, Zhen Wang, Chenjun Zhai, Guangxin Zhou, Jianning Zhao, Yicun Wang

Biomed Res Int. 2023; 2023: 1150768. Published online 2023 Feb 7. doi: 10.1155/2023/1150768

PMCID:: PMC9936457

Article PDF–7.2M

Select item 92998342.

Dysregulation of RalA signaling through dual regulatory mechanisms exerts its oncogenic functions in hepatocellular carcinoma

Lu Tian, Luqing Zhao, Karen Man‐Fong Sze, Charles Shing Kam, Vanessa Sheung‐In Ming, Xia Wang, Vanilla Xin Zhang, Daniel Wai‐Hung Ho, Tan‐To Cheung, Lo‐Kong Chan, Irene Oi‐Lin Ng

Hepatology. 2022 Jul; 76(1): 48–65. Published online 2021 Dec 17. doi: 10.1002/hep.32236

PMCID:: PMC9299834

Article PDF–12M

Select item 84335083.

Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs

Samuel G. Chamberlain, Andrea Gohlke, Arooj Shafiq, Iolo J. Squires, Darerca Owen, Helen R. Mott

Proc Natl Acad Sci U S A. 2021 Sep 7; 118(36): e2104219118. Published online 2021 Sep 3. doi: 10.1073/pnas.2104219118

PMCID:: PMC8433508

Article PDF–2.9M

Select item 81965234.

The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer

Katie A. Thies, Matthew W. Cole, Rachel E. Schafer, Jonathan M. Spehar, Dillon S. Richardson, Sarah A. Steck, Manjusri Das, Arthur W. Lian, Alo Ray, Reena Shakya, Sue E. Knoblaugh, Cynthia D. Timmers, Michael C. Ostrowski, Arnab Chakravarti, Gina M. Sizemore, Steven T. Sizemore

Breast Cancer Res. 2021; 23: 65. Published online 2021 Jun 12. doi: 10.1186/s13058-021-01438-3

PMCID:: PMC8196523

Article PDF–3.5M

Select item 75566285.

RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS

Marcel Seibold, Thorsten Stühmer, Nadine Kremer, Anja Mottok, Claus-Jürgen Scholz, Andreas Schlosser, Ellen Leich, Ulrike Holzgrabe, Daniela Brünnert, Santiago Barrio, K. Martin Kortüm, Antonio G. Solimando, Manik Chatterjee, Hermann Einsele, Andreas Rosenwald, Ralf C. Bargou, Torsten Steinbrunn

Haematologica. 2020 Sep 1; 105(9): 2316–2326. Published online 2019 Oct 10. doi: 10.3324/haematol.2019.223024

PMCID:: PMC7556628

Article PDF–1.8M

Select item 53566646.

Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C

Suthakar Ganapathy, Johan B Fagman, Ling Shen, Tianqi Yu, Xiaodong Zhou, Wei Dai, Alexandros Makriyannis, Changyan Chen

Oncotarget. 2016 Dec 20; 7(51): 84326–84337. Published online 2016 Oct 12. doi: 10.18632/oncotarget.12607

PMCID:: PMC5356664

Article PDF–3.5M

Select item 51900437.

Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer

Jitian Li, Liping Dai, Ningjing Lei, Mengtao Xing, Pei Li, Chenglin Luo, Carlos A. Casiano, Jian-Ying Zhang

Oncotarget. 2016 Jul 12; 7(28): 43546–43556. Published online 2016 Jun 7. doi: 10.18632/oncotarget.9869

PMCID:: PMC5190043

Article PDF–4.2M

Select item 39103328.

Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation

Nicole F. Neel, Jeran K. Stratford, Vaishali Shinde, Jeffrey A. Ecsedy, Timothy D. Martin, Channing J. Der, Jen Jen Yeh

Mol Cancer Ther. Author manuscript; available in PMC 2015 Jan 1.

Published in final edited form as: Mol Cancer Ther. 2014 Jan; 13(1): 122–133. Published online 2013 Nov 12. doi: 10.1158/1535-7163.MCT-12-1232

PMCID:: PMC3910332

Article PDF–3.1M

Select item 33077059.

miR-181a Post-Transcriptionally Downregulates Oncogenic RalA and Contributes to Growth Inhibition and Apoptosis in Chronic Myelogenous Leukemia (CML)

Jia Fei, Yumin Li, Xuejiao Zhu, Xiaochuang Luo

PLoS One. 2012; 7(3): e32834. Published online 2012 Mar 19. doi: 10.1371/journal.pone.0032834

PMCID:: PMC3307705

Article PDF–605K

Select item 306422410.

Control of Secondary Granule Release in Neutrophils by Ral GTPase

Celia X.-J. Chen, Ileana Soto, Ya-Lan Guo, Yuan Liu

J Biol Chem. 2011 Apr 1; 286(13): 11724–11733. Published online 2011 Jan 31. doi: 10.1074/jbc.M110.154203

PMCID:: PMC3064224

Article PDF–2.0M

Select item 306291811.

Activation and Involvement of Ral GTPases in Colorectal Cancer

Timothy D. Martin, Jonathan C. Samuel, Elizabeth D. Routh, Channing J. Der, Jen Jen Yeh

Cancer Res. Author manuscript; available in PMC 2012 Jan 1.

Published in final edited form as: Cancer Res. 2011 Jan 1; 71(1): 206–215. doi: 10.1158/0008-5472.CAN-10-1517

PMCID:: PMC3062918

Article PDF–999K

Select item 283912212.

Immunogenicity of RalA and its tissue-specific expression in hepatocellular carcinoma

Kaijuan Wang, Yao Chen, Siwei Liu, Suimin Qiu, Sanyou Gao, Xueyong Huang, Jintao Zhang, Xuanxian Peng, Jianying Zhang

Int J Immunopathol Pharmacol. Author manuscript; available in PMC 2010 Mar 16.

Published in final edited form as: Int J Immunopathol Pharmacol. 2009 Jul–Sep; 22(3): 735–743. doi: 10.1177/039463200902200319

PMCID:: PMC2839122

Article PDF–638K

Select item 127670113.

Crystal structure of the C3bot–RalA complex reveals a novel type of action of a bacterial exoenzyme

Alexander Pautsch, Martin Vogelsgesang, Jens Tränkle, Christian Herrmann, Klaus Aktories

EMBO J. 2005 Oct 19; 24(20): 3670–3680. Published online 2005 Sep 22. doi: 10.1038/sj.emboj.7600813

PMCID:: PMC1276701

Article PDF–530K

Select item 55626614.

Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase

Kenneth P. Holbourn, J. Mark Sutton, Hazel R. Evans, Clifford C. Shone, K. Ravi Acharya

Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15): 5357–5362. Published online 2005 Apr 4. doi: 10.1073/pnas.0501525102

PMCID:: PMC556266

Article PDF–712K

Select item 1022026515.

Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production

Mingxin Cao, Xinming Li, Duc-Anh Trinh, Shingo Yoshimachi, Kota Goto, Natsumi Sakata, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Yuxia Wang, Ryutaro Shirakawa, Hisanori Horiuchi

J Biol Chem. 2023 Jun; 299(6): 104754. Published online 2023 Apr 26. doi: 10.1016/j.jbc.2023.104754

PMCID:: PMC10220265

Article PDF–4.2M

Select item 629116216.

De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay

Susan M. Hiatt, Matthew B. Neu, Ryne C. Ramaker, Andrew A. Hardigan, Jeremy W. Prokop, Miroslava Hancarova, Darina Prchalova, Marketa Havlovicova, Jan Prchal, Viktor Stranecky, Dwight K. C. Yim, Zöe Powis, Boris Keren, Caroline Nava, Cyril Mignot, Marlene Rio, Anya Revah-Politi, Parisa Hemati, Nicholas Stong, Alejandro D. Iglesias, Sharon F. Suchy, Rebecca Willaert, Ingrid M. Wentzensen, Patricia G. Wheeler, Lauren Brick, Mariya Kozenko, Anna C. E. Hurst, James W. Wheless, Yves Lacassie, Richard M. Myers, Gregory S. Barsh, Zdenek Sedlacek, Gregory M. Cooper

PLoS Genet. 2018 Nov; 14(11): e1007671. Published online 2018 Nov 30. doi: 10.1371/journal.pgen.1007671

PMCID:: PMC6291162

Article PDF–1.7M

Select item 557524317.

Surface PD-L1, E-cadherin, CD24, and VEGFR2 as markers of epithelial cancer stem cells associated with rapid tumorigenesis

Goodwin G. Jinesh, Ganiraju C. Manyam, Chinedu O. Mmeje, Keith A. Baggerly, Ashish M. Kamat

Sci Rep. 2017; 7: 9602. Published online 2017 Aug 29. doi: 10.1038/s41598-017-08796-z

PMCID:: PMC5575243

Article PDF–9.0M

Select item 503406218.

Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells

Ying Jiang, Maria S. Sverdlov, Peter T. Toth, Long Shuang Huang, Guangwei Du, Yiyao Liu, Viswanathan Natarajan, Richard D. Minshall

J Biol Chem. 2016 Sep 23; 291(39): 20729–20738. Published online 2016 Aug 10. doi: 10.1074/jbc.M116.752485

PMCID:: PMC5034062

Article PDF–1.7M

Select item 499147519.

RalA, a GTPase targeted by miR-181a, promotes transformation and progression by activating the Ras-related signaling pathway in chronic myelogenous leukemia

Chunming Gu, Maoxiao Feng, Zhao Yin, Xiaochuang Luo, Juhua Yang, Yumin Li, Tianfu Li, Ruirui Wang, Jia Fei

Oncotarget. 2016 Apr 12; 7(15): 20561–20573. Published online 2016 Mar 8. doi: 10.18632/oncotarget.7987

PMCID:: PMC4991475

Article PDF–7.3M

Select item 451065020.

TD-60 links RalA GTPase function to the CPC in mitosis

Diana Papini, Lars Langemeyer, Maria A. Abad, Alastair Kerr, Itaru Samejima, Patrick A. Eyers, A. Arockia Jeyaprakash, Jonathan M. G. Higgins, Francis A. Barr, William C. Earnshaw

Nat Commun. 2015; 6: 7678. Published online 2015 Jul 9. doi: 10.1038/ncomms8678

PMCID:: PMC4510650

Article PDF–2.3M

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