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Select item 97373241.

Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity

Taylor M. Triolo, J. Quinn Matuschek, Roberto Castro-Gutierrez, Ali H. Shilleh, Shane P. M. Williams, Maria S. Hansen, Kristen McDaniel, Jessie M. Barra, Aaron Michels, Holger A. Russ

Cells. 2022 Dec; 11(23): 3845. Published online 2022 Nov 30. doi: 10.3390/cells11233845

PMCID:: PMC9737324

Article PDF–37M

Select item 94560942.

PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review

Jiachun Song, Jinxin Lan, Jiaping Tang, Na Luo

Int J Mol Sci. 2022 Sep; 23(17): 10025. Published online 2022 Sep 2. doi: 10.3390/ijms231710025

PMCID:: PMC9456094

Article PDF–719K

Select item 88291443.

PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis

Wenbin Kuang, Xiao Wang, Jiayu Ding, Jiaxing Li, Minghui Ji, Weijiao Chen, Liping Wang, Peng Yang

Front Immunol. 2022; 13: 805311. Published online 2022 Jan 27. doi: 10.3389/fimmu.2022.805311

PMCID:: PMC8829144

Article PDF–17M

Select item 88201104.

Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy

Qing Nian, Jérémy Berthelet, Marianna Parlato, Ariel E. Mechaly, Rongxing Liu, Jean‐Marie Dupret, Nadine Cerf‐Bensussan, Ahmed Haouz, Fernando Rodrigues Lima

Protein Sci. 2022 Feb; 31(2): 538–544. Published online 2021 Nov 27. doi: 10.1002/pro.4246

PMCID:: PMC8820110

Article PDF–4.8M

Select item 79903855.

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

Lu Chen, Yanan Zhang, Xin Shu, Qiong Chen, Tiantian Wei, Heman Wang, Xiaorong Wang, Qirou Wu, Xiaomei Zhang, Xiaoyan Liu, Suya Zheng, Lan Huang, Junyu Xiao, Chao Jiang, Bing Yang, Zhiping Wang, Xing Guo

Oncogene. Author manuscript; available in PMC 2021 Mar 24.

Published in final edited form as: Oncogene. 2021 Mar; 40(11): 1942–1956. Published online 2021 Feb 18. doi: 10.1038/s41388-021-01674-z

PMCID:: PMC7990385

Article PDF–2.6M

Select item 79393896.

PTPN2 regulates the activation of KRAS and plays a critical role in proliferation and survival of KRAS-driven cancer cells

Zhangsen Huang, Mingzhu Liu, Donghe Li, Yun Tan, Ruihong Zhang, Zhizhou Xia, Peihong Wang, Bo Jiao, Ping Liu, Ruibao Ren

J Biol Chem. 2020 Dec 25; 295(52): 18343–18354. Published online 2021 Jan 13. doi: 10.1074/jbc.RA119.011060

PMCID:: PMC7939389

Article PDF–2.9M

Select item 72443737.

Overexpression of TC-PTP in murine epidermis attenuates skin tumor formation

Mihwa Kim, Liza D. Morales, Cheol Jung Lee, Serena A. Olivarez, Woo Jin Kim, Joselin Hernandez, Srinivas Mummidi, Christopher Jenkinson, Andrew T. Tsin, Ik-Soon Jang, Thomas J. Slaga, Dae Joon Kim

Oncogene. Author manuscript; available in PMC 2020 Oct 14.

Published in final edited form as: Oncogene. 2020 May; 39(21): 4241–4256. Published online 2020 Apr 14. doi: 10.1038/s41388-020-1282-8

PMCID:: PMC7244373

Article PDF–3.3M

Select item 66162548.

Clinical and biological features of PTPN2-deleted adult and pediatric T-cell acute lymphoblastic leukemia

Marion Alcantara, Mathieu Simonin, Ludovic Lhermitte, Aurore Touzart, Marie Emilie Dourthe, Mehdi Latiri, Nathalie Grardel, Jean Michel Cayuela, Yves Chalandon, Carlos Graux, Hervé Dombret, Norbert Ifrah, Arnaud Petit, Elizabeth Macintyre, André Baruchel, Nicolas Boissel, Vahid Asnafi

Blood Adv. 2019 Jul 9; 3(13): 1981–1988. Published online 2019 Jul 3. doi: 10.1182/bloodadvances.2018028993

PMCID:: PMC6616254

Article PDF–938K

Select item 65711019.

The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype

Cynthia Veenstra, Elin Karlsson, Sanam Mirwani Mirwani, Bo Nordenskjöld, Tommy Fornander, Gizeh Pérez-Tenorio, Olle Stål

J Cancer Res Clin Oncol. 2019; 145(7): 1845–1856. Published online 2019 Apr 25. doi: 10.1007/s00432-019-02918-y

PMCID:: PMC6571101

Article PDF–1.5M

Select item 639465810.

PTPN2 deficiency along with activation of nuclear Akt predict endocrine resistance in breast cancer

Elin Karlsson, Cynthia Veenstra, Jon Gårsjö, Bo Nordenskjöld, Tommy Fornander, Olle Stål

J Cancer Res Clin Oncol. 2019; 145(3): 599–607. Published online 2018 Dec 4. doi: 10.1007/s00432-018-2810-6

PMCID:: PMC6394658

Article PDF–1.3M

Select item 595340411.

Molecular and clinical characterization of PTPN2 expression from RNA-seq data of 996 brain gliomas

Peng-fei Wang, Hong-qing Cai, Chuan-bao Zhang, Yan-Michael Li, Xiang Liu, Jing-hai Wan, Tao Jiang, Shou-wei Li, Chang-Xiang Yan

J Neuroinflammation. 2018; 15: 145. Published online 2018 May 15. doi: 10.1186/s12974-018-1187-4

PMCID:: PMC5953404

Article PDF–4.4M

Select item 576856912.

Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2

Declan F. McCole

Ann N Y Acad Sci. Author manuscript; available in PMC 2018 Jan 16.

Published in final edited form as: Ann N Y Acad Sci. 2012 Jun; 1257: 108–114. doi: 10.1111/j.1749-6632.2012.06522.x

PMCID:: PMC5768569

Article PDF–784K

Select item 542975413.

Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium

Yun Feng, Yanru Wang, Hongliang Liu, Zhensheng Liu, Coleman Mills, Younghun Han, Rayjean J. Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeboeller, Albert Rosenberger, Richard S. Houlston, Neil E. Caporaso, Maria Teresa Landi, Irene Brueske, Angela Risch, Yuanqing Ye, Xifeng Wu, David C. Christiani, Christopher I. Amos, Qingyi Wei

Sci Rep. 2017; 7: 825. Published online 2017 Apr 11. doi: 10.1038/s41598-017-00850-0

PMCID:: PMC5429754

Article PDF–2.4M

Select item 456694414.

Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus

Hui Peng, Jiamei Li, Xiaoyun Chen, Xiao Zhou, Weiwei Zhu, Feng Li

Med Sci Monit. 2015; 21: 2653–2658. Published online 2015 Sep 7. doi: 10.12659/MSM.893607

PMCID:: PMC4566944

Article PDF–233K

Select item 382090015.

Spermidine Stimulates T Cell Protein-tyrosine Phosphatase-mediated Protection of Intestinal Epithelial Barrier Function

Harrison M. Penrose, Ronald R. Marchelletta, Moorthy Krishnan, Declan F. McCole

J Biol Chem. 2013 Nov 8; 288(45): 32651–32662. Published online 2013 Sep 10. doi: 10.1074/jbc.M113.475962

PMCID:: PMC3820900

Article PDF–2.0M

Select item 368876216.

Identification of the Tyrosine-Protein Phosphatase Non-Receptor Type 2 as a Rheumatoid Arthritis Susceptibility Locus in Europeans

Joanna E. Cobb, Darren Plant, Edward Flynn, Meriem Tadjeddine, Philippe Dieudé, François Cornélis, Lisbeth Ärlestig, Solbritt Rantapää Dahlqvist, George Goulielmos, Dimitrios T. Boumpas, Prodromos Sidiropoulos, Sophine B. Krintel, Lykke M. Ørnbjerg, Merete L. Hetland, Lars Klareskog, Thomas Haeupl, Andrew Filer, Christopher D. Buckley, Karim Raza, Torsten Witte, Reinhold E. Schmidt, Oliver FitzGerald, Douglas Veale, Stephen Eyre, Jane Worthington

PLoS One. 2013; 8(6): e66456. Published online 2013 Jun 20. doi: 10.1371/journal.pone.0066456

PMCID:: PMC3688762

Article PDF–101K

Select item 331007717.

PTPN2 Gene Variants Are Associated with Susceptibility to Both Crohn's Disease and Ulcerative Colitis Supporting a Common Genetic Disease Background

Jürgen Glas, Johanna Wagner, Julia Seiderer, Torsten Olszak, Martin Wetzke, Florian Beigel, Cornelia Tillack, Johannes Stallhofer, Matthias Friedrich, Christian Steib, Burkhard Göke, Thomas Ochsenkühn, Nazanin Karbalai, Julia Diegelmann, Darina Czamara, Stephan Brand

PLoS One. 2012; 7(3): e33682. Published online 2012 Mar 21. doi: 10.1371/journal.pone.0033682

PMCID:: PMC3310077

Article PDF–138K

Select item 320869418.

Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin’s lymphoma and T-cell non-Hodgkin’s lymphoma

Maria Kleppe, Thomas Tousseyn, Eva Geissinger, Zeynep Kalender Atak, Stein Aerts, Andreas Rosenwald, Iwona Wlodarska, Jan Cools

Haematologica. 2011 Nov; 96(11): 1723–1727. doi: 10.3324/haematol.2011.041921

PMCID:: PMC3208694

Article PDF–1.2M

Select item 305868019.

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4⁺ T cells

S Alice Long, Karen Cerosaletti, Jia Yin Wan, Jhon-Chun Ho, Megan Tatum, Shan Wei, Heather G. Shilling, Jane H Buckner

Genes Immun. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Genes Immun. 2011 Mar; 12(2): 116–125. Published online 2010 Dec 23. doi: 10.1038/gene.2010.54

PMCID:: PMC3058680

Article PDF–2.2M

Select item 295733820.

Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion

Michael Scharl, Ivan Rudenko, Declan F. McCole

Am J Physiol Gastrointest Liver Physiol. 2010 Oct; 299(4): G935–G945. Published online 2010 Aug 5. doi: 10.1152/ajpgi.00106.2010

PMCID:: PMC2957338

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