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Select item 98709801.

PTK6 inhibits autophagy to promote uveal melanoma tumorigenesis by binding to SOCS3 and regulating mTOR phosphorylation

Bo Liu, Xueting Yao, Chaoyang Zhang, Yufen Liu, Li Wei, Qinying Huang, Mengting Wang, Yanchen Zhang, Danning Hu, Wencan Wu

Cell Death Dis. 2023 Jan; 14(1): 55. Published online 2023 Jan 23. doi: 10.1038/s41419-023-05590-w

PMCID:: PMC9870980

Article PDF–7.2M

Select item 89508342.

Breast Tumour Kinase (Brk/PTK6) Contributes to Breast Tumour Xenograft Growth and Modulates Chemotherapeutic Responses In Vitro

Rajpal S. Burmi, Gary M. Box, Umar Wazir, Haroon A. Hussain, Julie A. Davies, William J. Court, Suzanne A. Eccles, Wen G. Jiang, Kefah Mokbel, Amanda J. Harvey

Genes (Basel) 2022 Mar; 13(3): 402. Published online 2022 Feb 24. doi: 10.3390/genes13030402

PMCID:: PMC8950834

Article PDF–2.6M

Select item 77166963.

Targeting Protein Tyrosine Kinase 6 in Cancer

Milica B. Gilic, Angela L. Tyner

Biochim Biophys Acta Rev Cancer. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Biochim Biophys Acta Rev Cancer. 2020 Dec; 1874(2): 188432. Published online 2020 Sep 18. doi: 10.1016/j.bbcan.2020.188432

PMCID:: PMC7716696

Article PDF–1.2M

Select item 66939414.

Vemurafenib Inhibits Active PTK6 in PTEN-null Prostate Tumor Cells

Darren J. Wozniak, Ben Hitchinson, Milica Gilic, Wenjun Bie, Vadim Gaponenko, Angela L. Tyner

Mol Cancer Ther. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Mol Cancer Ther. 2019 May; 18(5): 937–946. Published online 2019 Mar 29. doi: 10.1158/1535-7163.MCT-18-0862

PMCID:: PMC6693941

Article PDF–1.8M

Select item 63356855.

Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells

Sayem Miah, Edward Bagu, Raghuveera Goel, Yetunde Ogunbolude, Chenlu Dai, Alison Ward, Frederick S. Vizeacoumar, Gerald Davies, Franco J. Vizeacoumar, Deborah Anderson, Kiven Erique Lukong

BMC Cancer. 2019; 19: 78. Published online 2019 Jan 16. doi: 10.1186/s12885-018-5186-8

PMCID:: PMC6335685

Article PDF–2.4M

Select item 59917046.

Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers

Luping Qiu, Kymberly Levine, Ketan S. Gajiwala, Ciarán N. Cronin, Asako Nagata, Eric Johnson, Michelle Kraus, John Tatlock, Robert Kania, Timothy Foley, Shaoxian Sun

PLoS One. 2018; 13(6): e0198374. Published online 2018 Jun 7. doi: 10.1371/journal.pone.0198374

PMCID:: PMC5991704

Article PDF–6.1M

Select item 49124397.

Kinase-Dependent and Independent Roles for PTK6 in Colon Cancer

Priya S. Mathur, Jessica J. Gierut, Grace Guzman, Hui Xie, Rosa M. Xicola, Xavier Llor, Michael I. Chastkofsky, Ansu O. Perekatt, Angela L. Tyner

Mol Cancer Res. Author manuscript; available in PMC 2017 Jun 1.

Published in final edited form as: Mol Cancer Res. 2016 Jun; 14(6): 563–573. Published online 2016 Mar 16. doi: 10.1158/1541-7786.MCR-15-0450

PMCID:: PMC4912439

Article PDF–1.9M

Select item 49101968.

The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer

Xiao-Jing Wang, Ying Xiong, Ze-Biao Ma, Jian-Chuan Xia, Yan-Fang Li

Chin J Cancer. 2016; 35: 54. Published online 2016 Jun 16. doi: 10.1186/s40880-016-0114-2

PMCID:: PMC4910196

Article PDF–1.5M

Select item 47578119.

Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition

Tiffany Tsui, W. Todd Miller

Biochemistry. Author manuscript; available in PMC 2016 Feb 18.

Published in final edited form as: Biochemistry. 2015 May 26; 54(20): 3173–3182. Published online 2015 May 13. doi: 10.1021/acs.biochem.5b00303

PMCID:: PMC4757811

Article PDF–465K

Select item 417161110.

PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors

Maoyu Peng, Rajyasree Emmadi, Zebin Wang, Elizabeth L. Wiley, Peter H. Gann, Seema A. Khan, Nilanjana Banerji, William McDonald, Szilard Asztalos, Thao N.D. Pham, Debra A. Tonetti, Angela L. Tyner

Oncotarget. 2014 Aug; 5(15): 6038–6048. Published online 2014 Jun 30. doi: 10.18632/oncotarget.2153

PMCID:: PMC4171611

Article PDF–2.9M

Select item 400686911.

PTK6 Promotes Cancer Migration and Invasion in Pancreatic Cancer Cells Dependent on ERK Signaling

Hiroaki Ono, Marc D. Basson, Hiromichi Ito

PLoS One. 2014; 9(5): e96060. Published online 2014 May 1. doi: 10.1371/journal.pone.0096060

PMCID:: PMC4006869

Article PDF–2.2M

Select item 368669312.

Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis

Li-na Liu, Pei-yu Huang, Zhi-rui Lin, Li-juan Hu, Jian-zhong Liang, Man-zhi Li, Lin-quan Tang, Mu-sheng Zeng, Qian Zhong, Bo-hang Zeng

J Transl Med. 2013; 11: 140. Published online 2013 Jun 9. doi: 10.1186/1479-5876-11-140

PMCID:: PMC3686693

Article PDF–1.9M

Select item 359950313.

Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma

Xue-Kui Liu, Xin-Rui Zhang, Qian Zhong, Man-Zhi Li, Zhi-Min Liu, Zhi-Rui Lin, Di Wu, Mu-Sheng Zeng

J Transl Med. 2013; 11: 59. Published online 2013 Mar 7. doi: 10.1186/1479-5876-11-59

PMCID:: PMC3599503

Article PDF–1.8M

Select item 350751214.

Targeting Protein Tyrosine Kinase 6 Enhances Apoptosis of Colon Cancer Cells Following DNA Damage

Jessica J. Gierut, Priya S. Mathur, Wenjun Bie, Jin Han, Angela L. Tyner

Mol Cancer Ther. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Mol Cancer Ther. 2012 Nov; 11(11): 2311–2320. Published online 2012 Sep 18. doi: 10.1158/1535-7163.MCT-12-0009

PMCID:: PMC3507512

Article PDF–2.0M

Select item 307982915.

Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes

J. Tupper, M. R. Crompton, A. J. Harvey

Arch Dermatol Res. 2011; 303(4): 293–297. Published online 2011 Jan 15. doi: 10.1007/s00403-010-1118-4

PMCID:: PMC3079829

Article PDF–228K

Select item 273114116.

Brk Protects Breast Cancer Cells from Autophagic Cell Death Induced by Loss of Anchorage

Amanda J. Harvey, Caroline J. Pennington, Sarah Porter, Rajpal S. Burmi, Dylan R. Edwards, William Court, Suzanne A. Eccles, Mark R. Crompton

Am J Pathol. 2009 Sep; 175(3): 1226–1234. doi: 10.2353/ajpath.2009.080811

PMCID:: PMC2731141

Article PDF–472K

Select item 256707717.

Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients

M Aubele, A K Walch, N Ludyga, H Braselmann, M J Atkinson, B Luber, G Auer, S Tapio, T Cooke, J M S Bartlett

Br J Cancer. 2008 Oct 7; 99(7): 1089–1095. Published online 2008 Sep 9. doi: 10.1038/sj.bjc.6604660

PMCID:: PMC2567077

Article PDF–152K

Select item 160657818.

Expression and Oncogenic Role of Brk (PTK6/Sik) Protein Tyrosine Kinase in Lymphocytes

Monika Kasprzycka, Miroslaw Majewski, Zhi-Jong Wang, Andrzej Ptasznik, Maria Wysocka, Qian Zhang, Michal Marzec, Phyllis Gimotty, Mark R. Crompton, Mariusz A. Wasik

Am J Pathol. 2006 May; 168(5): 1631–1641. doi: 10.2353/ajpath.2006.050521