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Select item 69342241.

Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1^R122H

Fu Gui, Yuebo Zhang, Jianhua Wan, Xianbao Zhan, Yao Yao, Yinghua Li, Ashley N. Haddock, Ji Shi, Jia Guo, Jiaxiang Chen, Xiaohui Zhu, Brandy H. Edenfield, Lu Zhuang, Cheng Hu, Ying Wang, Debabrata Mukhopadhyay, Evette S. Radisky, Lizhi Zhang, Aurelia Lugea, Stephen J. Pandol, Yan Bi, Baoan Ji

J Clin Invest. 2020 Jan 2; 130(1): 189–202. Published online 2019 Nov 18. doi: 10.1172/JCI130172

PMCID:: PMC6934224

Abstract Article PDF–17M

Select item 67446822.

PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer

Qicai Liu, Ling Guo, Sheng Zhang, Jingwen Wang, Xinhua Lin, Feng Gao

Mol Med. 2019; 25: 44. Published online 2019 Sep 14. doi: 10.1186/s10020-019-0111-4

PMCID:: PMC6744682

Abstract Article PDF–2.4M

Select item 66259983.

Micro RNAs upregulated in Vitiligo skin play an important role in its aetiopathogenesis by altering TRP1 expression and keratinocyte-melanocytes cross-talk

Utpreksha Vaish, Avinash A. Kumar, Swati Varshney, Shreya Ghosh, Shantanu Sengupta, Chandni Sood, Hemanta K. Kar, Pankaj Sharma, Vivek T. Natarajan, Rajesh S. Gokhale, Rajni Rani

Sci Rep. 2019; 9: 10079. Published online 2019 Jul 12. doi: 10.1038/s41598-019-46529-6

Correction in:: Sci Rep. 2020; 10: 2166.

PMCID:: PMC6625998

Abstract Article PDF–8.5M

Select item 54241034.

Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death

T Athwal, W Huang, R Mukherjee, D Latawiec, M Chvanov, R Clarke, K Smith, F Campbell, C Merriman, D Criddle, R Sutton, J Neoptolemos, N Vlatković

Cell Death Dis. 2014 Apr; 5(4): e1165. Published online 2014 Apr 10. doi: 10.1038/cddis.2014.120

PMCID:: PMC5424103

Abstract Article PDF–6.1M

Select item 48241765.

Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis

Anita Balázs, Péter Hegyi, Miklós Sahin-Tóth

Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1; 310(7): G477–G486. Published online 2016 Jan 28. doi: 10.1152/ajpgi.00444.2015

PMCID:: PMC4824176

Abstract Article

Select item 43217436.

The Histopathology of PRSS1 Hereditary Pancreatitis

Aatur D. Singhi, Reetesh K. Pai, Jeffrey A. Kant, Tanner L. Bartholow, Herbert J. Zeh, Kenneth K. Lee, Martin Wijkstrom, Dhiraj Yadav, Rita Bottino, Randall E. Brand, Jennifer S. Chennat, Mark E. Lowe, Georgios I. Papachristou, Adam Slivka, David C. Whitcomb, Abhinav Humar

Am J Surg Pathol. Author manuscript; available in PMC 2015 Feb 9.

Published in final edited form as: Am J Surg Pathol. 2014 Mar; 38(3): 346–353. doi: 10.1097/PAS.0000000000000164

PMCID:: PMC4321743

Abstract Article PDF–1.2M

Select item 43059447.

A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene

Theeraphong Pho-Iam, Wanna Thongnoppakhun, Pa-Thai Yenchitsomanus, Chanin Limwongse

World J Gastroenterol. 2005 Mar 21; 11(11): 1634–1638. Published online 2005 Mar 21. doi: 10.3748/wjg.v11.i11.1634

PMCID:: PMC4305944

Abstract Article PDF–405K

Select item 40920718.

Tyrosine Sulfation of Human Trypsin Steers S2’ Subsite Selectivity towards Basic Amino Acids

András Szabó, Moh’d A. Salameh, Maren Ludwig, Evette S. Radisky, Miklós Sahin-Tóth

PLoS One. 2014; 9(7): e102063. Published online 2014 Jul 10. doi: 10.1371/journal.pone.0102063

PMCID:: PMC4092071

Abstract Article PDF–3.2M

Select item 39310379.

Zymogen Activation Confers Thermodynamic Stability on a Key Peptide Bond and Protects Human Cationic Trypsin from Degradation

András Szabó, Evette S. Radisky, Miklós Sahin-Tóth

J Biol Chem. 2014 Feb 21; 289(8): 4753–4761. Published online 2014 Jan 8. doi: 10.1074/jbc.M113.538884

PMCID:: PMC3931037

Abstract Article PDF–1.8M

Select item 369179610.

A Comprehensive Study Indicates PRSS1 Gene Is Significantly Associated with Pancreatitis

Jie Liu, Hong-xin Zhang

Int J Med Sci. 2013; 10(8): 981–987. Published online 2013 Jun 13. doi: 10.7150/ijms.6164

PMCID:: PMC3691796

Abstract Article PDF–963K

Select item 367644311.

Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis associated cationic trypsinogen mutants

Andrea Geisz, Péter Hegyi, Miklós Sahin-Tóth

FEBS J. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: FEBS J. 2013 Jun; 280(12): 2888–2899. Published online 2013 May 16. doi: 10.1111/febs.12292

PMCID:: PMC3676443

Abstract Article PDF–5.6M

Select item 367108612.

PRSS1_p.Leu81Met mutation results in autoimmune pancreatitis

Feng Gao, Yue-Ming Li, Guo-Lin Hong, Zhi-Feng Xu, Qi-Cai Liu, Qing-Liang He, Li-Qing Lin, Shao-Huang Weng

World J Gastroenterol. 2013 Jun 7; 19(21): 3332–3338. Published online 2013 Jun 7. doi: 10.3748/wjg.v19.i21.3332

PMCID:: PMC3671086

Abstract Article PDF–1.6M

Select item 367107913.

Low trypsinogen-1 expression in pediatric ulcerative colitis patients who undergo surgery

Maija Piekkala, Jaana Hagström, Maarit Tanskanen, Risto Rintala, Caj Haglund, Kaija-Leena Kolho

World J Gastroenterol. 2013 Jun 7; 19(21): 3272–3280. Published online 2013 Jun 7. doi: 10.3748/wjg.v19.i21.3272

PMCID:: PMC3671079

Abstract Article PDF–1.5M

Select item 308848814.

Intragenic duplication: a novel mutational mechanism in hereditary pancreatitis

Maiken T. Joergensen, Andrea Geisz, Klaus Brusgaard, Ove B. Schaffalitzky de Muckadell, Péter Hegyi, Anne-Marie Gerdes, Miklós Sahin-Tóth

Pancreas. Author manuscript; available in PMC 2012 May 1.

Published in final edited form as: Pancreas. 2011 May; 40(4): 540–546. doi: 10.1097/MPA.0b013e3182152fdf

PMCID:: PMC3088488

Abstract Article PDF–568K

Select item 293084015.

Uncertainties in the classification of human cationic trypsinogen (PRSS1) variants as hereditary pancreatitis-associated mutations

Richárd Szmola, Miklós Sahin-Tóth

J Med Genet. Author manuscript; available in PMC 2011 May 1.

Published in final edited form as: J Med Genet. 2010 May; 47(5): 348–350. doi: 10.1136/jmg.2009.072751

PMCID:: PMC2930840

Abstract Article PDF–47K

Select item 278518316.

Intracellular Autoactivation of Human Cationic Trypsinogen Mutants Causes Reduced Trypsinogen Secretion and Acinar Cell Death

Éva Kereszturi, Miklós Sahin-Tóth

J Biol Chem. 2009 Nov 27; 284(48): 33392–33399. Published online 2009 Sep 29. doi: 10.1074/jbc.M109.056812

PMCID:: PMC2785183

Abstract Article PDF–1.4M

Select item 264526817.

Human cationic trypsinogen is sulfated on tyrosine-154

Miklós Sahin-Tóth, Zoltán Kukor, Zsófia Nemoda

FEBS J. Author manuscript; available in PMC 2009 Feb 19.

Published in final edited form as: FEBS J. 2006 Nov; 273(22): 5044–5050. doi: 10.1111/j.1742-4658.2006.05501.x

PMCID:: PMC2645268

Abstract Article PDF–1.2M

Select item 177311818.

Novel cationic trypsinogen (PRSS1) N29T and R122C mutations cause autosomal dominant hereditary pancreatitis

R Pfützer, E Myers, S Applebaum-Shapiro, R Finch, I Ellis, J Neoptolemos, J A Kant, D C Whitcomb

Gut. 2002 Feb; 50(2): 271–272. doi: 10.1136/gut.50.2.271

PMCID:: PMC1773118

Abstract Article PDF–130K

Select item 173448319.

A CGC>CAT gene conversion-like event resulting in the R122H mutation in the cationic trypsinogen gene and its implication in the genotyping of pancreatitis

J. CHEN, O. RAGUENES, C. FEREC, P. DEPREZ, C. VERELLEN-DUMOULIN

J Med Genet. 2000 Nov; 37(11): e36. doi: 10.1136/jmg.37.11.e36

PMCID:: PMC1734483

Summary PDF–93K

Select item 173432820.

Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis

C Ferec, O Raguenes, R Salomon, C Roche, J Bernard, M Guillot, I Quere, C Faure, B Mercier, M Audrezet, P Guillausseau, C Dupont, A Munnich, J Bignon, L Le Bodic

J Med Genet. 1999 Mar; 36(3): 228–232.