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Select item 85728581.

Role of PKM2-Mediated Immunometabolic Reprogramming on Development of Cytokine Storm

Zhijun Liu, Yifei Le, Hang Chen, Ji Zhu, Dezhao Lu

Front Immunol. 2021; 12: 748573. Published online 2021 Oct 25. doi: 10.3389/fimmu.2021.748573

PMCID:: PMC8572858

Article PDF–5.8M

Select item 57845282.

PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway

Yang Cheng, Yun Zhu, Jiajia Xu, Min Yang, Peiyu Chen, Wanfu Xu, Junhong Zhao, Lanlan Geng, Sitang Gong

Mol Cancer. 2018; 17: 13. Published online 2018 Jan 24. doi: 10.1186/s12943-017-0747-z

PMCID:: PMC5784528

Article PDF–4.9M

Select item 48008243.

CagA of Helicobacter pylori interacts with and inhibits the serine-threonine kinase PRK2

Jyoti Prasad Mishra, David Cohen, Andrea Zamperone, Dragana Nesic, Anne Muesch, Markus Stein

Cell Microbiol. Author manuscript; available in PMC 2016 Mar 21.

Published in final edited form as: Cell Microbiol. 2015 Nov; 17(11): 1670–1682. Published online 2015 Jun 19. doi: 10.1111/cmi.12464

PMCID:: PMC4800824

Article PDF–1.9M

Select item 33702434.

Regulation of Protein Kinase C-related Protein Kinase 2 (PRK2) by an Intermolecular PRK2-PRK2 Interaction Mediated by Its N-terminal Domain

Angelika F. Bauer, Silvina Sonzogni, Lucas Meyer, Stefan Zeuzem, Albrecht Piiper, Ricardo M. Biondi, Sonja Neimanis

J Biol Chem. 2012 Jun 8; 287(24): 20590–20602. Published online 2012 Apr 16. doi: 10.1074/jbc.M111.327437

PMCID:: PMC3370243

Article PDF–1.9M

Select item 81835115.

LINC00668 cooperated with HuR dependent upregulation of PKN2 to facilitate gastric cancer metastasis

Jutang Li, Wei Dong, Qixia Jiang, Fenglian Zhang, Hui Dong

Cancer Biol Ther. 2021; 22(4): 311–323. Published online 2021 Apr 20. doi: 10.1080/15384047.2021.1905138

PMCID:: PMC8183511

Article PDF–5.6M

Select item 56685946.

Protein kinase N2 regulates AMP kinase signaling and insulin responsiveness of glucose metabolism in skeletal muscle

Maxwell A. Ruby, Isabelle Riedl, Julie Massart, Marcus Åhlin, Juleen R. Zierath

Am J Physiol Endocrinol Metab. 2017 Oct 1; 313(4): E483–E491. Published online 2017 Jul 18. doi: 10.1152/ajpendo.00147.2017

PMCID:: PMC5668594

Article

Select item 46949137.

Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer

Aine G. O'Sullivan, Eamon P. Mulvaney, Paula B. Hyland, B. Therese Kinsella

Oncotarget. 2015 Sep 22; 6(28): 26437–26456. Published online 2015 Jul 20. doi: 10.18632/oncotarget.4664

PMCID:: PMC4694913

Article PDF–2.2M

Select item 16797728.

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

Matthias Engel, Valerie Hindie, Laura A Lopez-Garcia, Adriana Stroba, Francis Schaeffer, Iris Adrian, Jochen Imig, Leila Idrissova, Wolfgang Nastainczyk, Stefan Zeuzem, Pedro M Alzari, Rolf W Hartmann, Albrecht Piiper, Ricardo M Biondi

EMBO J. 2006 Nov 29; 25(23): 5469–5480. Published online 2006 Nov 16. doi: 10.1038/sj.emboj.7601416

PMCID:: PMC1679772

Article PDF–277K

Select item 2320749.

The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.

S Vincent, J Settleman

Mol Cell Biol. 1997 Apr; 17(4): 2247–2256. doi: 10.1128/mcb.17.4.2247

PMCID:: PMC232074

Summary PDF–1.1M

Select item 395812910.

Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

Matthew D. Falk, Wei Liu, Ben Bolaños, Keziban Unsal-Kacmaz, Anke Klippel, Stephan Grant, Alexei Brooun, Sergei Timofeevski

Biosci Rep. 2014; 34(2): e00097. Prepublished online 2014 Jan 29. Published online 2014 Mar 18. doi: 10.1042/BSR20140010

PMCID:: PMC3958129

Article PDF–1.6M

Select item 15071511.

MEK Kinase 2 and the Adaptor Protein Lad Regulate Extracellular Signal-Regulated Kinase 5 Activation by Epidermal Growth Factor via Src

Weiyong Sun, Xudong Wei, Kamala Kesavan, Timothy P. Garrington, Ruihua Fan, Junjie Mei, Steven M. Anderson, Erwin W. Gelfand, Gary L. Johnson

Mol Cell Biol. 2003 Apr; 23(7): 2298–2308. doi: 10.1128/MCB.23.7.2298-2308.2003

PMCID:: PMC150715

Article PDF–476K

Select item 705426712.

Novel roles of PRK1 and PRK2 in cilia and cancer biology

Hitesh Patel, Jun Li, Ana Herrero, Jakob Kroboth, Adam Byron, Alex Von Kriegsheim, Valerie Brunton, Neil Carragher, Toby Hurd, Margaret Frame

Sci Rep. 2020; 10: 3902. Published online 2020 Mar 3. doi: 10.1038/s41598-020-60604-3

PMCID:: PMC7054267

Article PDF–3.2M

Select item 484610813.

STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis

Vincent J. Guen, Carly Gamble, Dahlia E. Perez, Sylvie Bourassa, Hildegard Zappel, Jutta Gärtner, Jacqueline A. Lees, Pierre Colas

Cell Cycle. 2016; 15(5): 678–688. Published online 2016 Mar 30. doi: 10.1080/15384101.2016.1147632

PMCID:: PMC4846108

Article PDF–1.3M

Select item 249468514.

Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies

Joshua P. Lewis, Nicholette D. Palmer, Pamela J. Hicks, Michele M. Sale, Carl D. Langefeld, Barry I. Freedman, Jasmin Divers, Donald W. Bowden

Diabetes. 2008 Aug; 57(8): 2220–2225. doi: 10.2337/db07-1319

PMCID:: PMC2494685

Article PDF–74K

Select item 855355815.

Protein kinase N2 mediates flow-induced endothelial NOS activation and vascular tone regulation

Young-June Jin, Ramesh Chennupati, Rui Li, Guozheng Liang, ShengPeng Wang, András Iring, Johannes Graumann, Nina Wettschureck, Stefan Offermanns

J Clin Invest. 2021 Nov 1; 131(21): e145734. Published online 2021 Nov 1. doi: 10.1172/JCI145734

PMCID:: PMC8553558

Article PDF–7.7M

Select item 418988216.

Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2

Sabrina Höfling, Julia Scharnert, Christoph Cromme, Jessica Bertrand, Thomas Pap, M Alexander Schmidt, Christian Rüter

Virulence. 2014 Oct 1; 5(7): 761–771. Published online 2014 May 15. doi: 10.4161/viru.29062

PMCID:: PMC4189882

Article PDF–2.8M

Select item 313076717.

Regulatory Domain Selectivity in the Cell-Type Specific PKN-Dependence of Cell Migration

Sylvie Lachmann, Amy Jevons, Manu De Rycker, Adele Casamassima, Simone Radtke, Alejandra Collazos, Peter J. Parker

PLoS One. 2011; 6(7): e21732. Published online 2011 Jul 6. doi: 10.1371/journal.pone.0021732

PMCID:: PMC3130767

Article PDF–832K

Select item 182939118.

Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis

Anja Schmidt, Joanne Durgan, Ana Magalhaes, Alan Hall

EMBO J. 2007 Mar 21; 26(6): 1624–1636. Published online 2007 Mar 1. doi: 10.1038/sj.emboj.7601637

PMCID:: PMC1829391

Article PDF–582K

Select item 302634619.

Structural Constraints on Human Immunodeficiency Virus Type 1 Nef Function

Alexa Raney, Alice Y. Shaw, John L. Foster, J. Victor Garcia

Virology. Author manuscript; available in PMC 2011 Jan 25.

Published in final edited form as: Virology. 2007 Nov 10; 368(1): 7–16. Published online 2007 Jul 16. doi: 10.1016/j.virol.2007.02.036

PMCID:: PMC3026346

Article PDF–845K

Select item 378452720.

Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling

Jennifer E. Ho, Wei-Yu Chen, Ming-Huei Chen, Martin G. Larson, Elizabeth L. McCabe, Susan Cheng, Anahita Ghorbani, Erin Coglianese, Valur Emilsson, Andrew D. Johnson, Stefan Walter, Nora Franceschini, Christopher J. O’Donnell, CARDIoGRAM Consortium, CHARGE Inflammation Working Group, Abbas Dehghan, Chen Lu, Daniel Levy, Christopher Newton-Cheh, CHARGE Heart Failure Working Group, Honghuang Lin, Janine F. Felix, Eric R. Schreiter, Ramachandran S. Vasan, James L. Januzzi, Richard T. Lee, Thomas J. Wang

J Clin Invest. 2013 Oct 1; 123(10): 4208–4218. Published online 2013 Sep 3. doi: 10.1172/JCI67119

PMCID:: PMC3784527

Article PDF–1.4M

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