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Select item 110096751.

Deletion of the TMEM30A gene enables leukemic cell evasion of NK cell cytotoxicity

Linnea Kristenson, Chiara Badami, Angelica Ljungberg, Erna Islamagic, Yarong Tian, Guojiang Xie, Brwa Ali Hussein, Silvia Pesce, Ka-Wei Tang, Fredrik B. Thorén

Proc Natl Acad Sci U S A. 2024 Apr 9; 121(15): e2316447121. Published online 2024 Apr 1. doi: 10.1073/pnas.2316447121

PMCID:: PMC11009675

Article PDF–4.1M

Select item 104059092.

CDC50A is required for aminophospholipid transport and cell fusion in mouse C2C12 myoblasts

Marta Grifell-Junyent, Julia F. Baum, Silja Välimets, Andreas Herrmann, Coen C. Paulusma, Rosa L. López-Marqués, Thomas Günther Pomorski

J Cell Sci. 2022 Mar 1; 135(5): jcs258649. Published online 2021 Oct 19. doi: 10.1242/jcs.258649

PMCID:: PMC10405909

Article

Select item 84803323.

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

Daisuke Ennishi, Shannon Healy, Ali Bashashati, Saeed Saberi, Christoffer Hother, Anja Mottok, Fong Chun Chan, Lauren Chong, Libin Abraham, Robert Kridel, Merrill Boyle, Barbara Meissner, Tomohiro Aoki, Katsuyoshi Takata, Bruce W. Woolcock, Elena Viganò, Michael Gold, Laurie L. Molday, Robert S. Molday, Adele Telenius, Michael Y. Li, Nicole Wretham, Nancy Dos Santos, Mark Wong, Natasja N. Viller, Robert A. Uger, Gerben Duns, Abigail Baticados, Angel Madero, Brianna N. Bristow, Pedro Farinha, Graham W. Slack, Susana Ben-Neriah, Daniel Lai, Allen W. Zhang, Sohrab Salehi, Hennady P. Shulha, Derek S. Chiu, Sara Mostafavi, Alina S. Gerrie, Da Wei Huang, Christopher Rushton, Diego Villa, Laurie H. Sehn, Kerry J. Savage, Andrew J. Mungall, Andrew P. Weng, Marcel B. Bally, Ryan D. Morin, Gabriela V. Cohen Freue, Louis M. Staudt, Joseph M. Connors, Marco A. Marra, Sohrab P. Shah, Randy D. Gascoyne, David W. Scott, Christian Steidl

Nat Med. Author manuscript; available in PMC 2021 Sep 29.

Published in final edited form as: Nat Med. 2020 Apr; 26(4): 577–588. Published online 2020 Feb 24. doi: 10.1038/s41591-020-0757-z

PMCID:: PMC8480332

Article PDF–5.6M

Select item 73833784.

Crystal structure of a human plasma membrane phospholipid flippase

Hanayo Nakanishi, Katsumasa Irie, Katsumori Segawa, Kazuya Hasegawa, Yoshinori Fujiyoshi, Shigekazu Nagata, Kazuhiro Abe

J Biol Chem. 2020 Jul 24; 295(30): 10180–10194. Published online 2020 Jun 3. doi: 10.1074/jbc.RA120.014144

PMCID:: PMC7383378

Article PDF–8.8M

Select item 58087765.

The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane

Katsumori Segawa, Sachiko Kurata, Shigekazu Nagata

J Biol Chem. 2018 Feb 9; 293(6): 2172–2182. Published online 2017 Dec 24. doi: 10.1074/jbc.RA117.000289

PMCID:: PMC5808776

Article PDF–3.8M

Select item 30734576.

Human TMEM30a Promotes Uptake of Anti-tumor and Bioactive Choline Phospholipids into Mammalian Cells

Rui Chen, Erin Brady, Thomas M. McIntyre

J Immunol. Author manuscript; available in PMC 2012 Mar 1.

Published in final edited form as: J Immunol. 2011 Mar 1; 186(5): 3215–3225. Published online 2011 Feb 2. doi: 10.4049/jimmunol.1002710

PMCID:: PMC3073457

Article PDF–3.7M

Select item 82462687.

Loss of phosphatidylserine flippase β-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis

Wenjing Liu, Lei Peng, Wanli Tian, Yi Li, Ping Zhang, Kuanxiang Sun, Yeming Yang, Xiao Li, Guisen Li, Xianjun Zhu

Dis Model Mech. 2021 Jun 1; 14(6): dmm048777. Published online 2021 Jun 25. doi: 10.1242/dmm.048777

PMCID:: PMC8246268

Article

Select item 60807558.

TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes

Nobumasa Takasugi, Runa Araya, Yuji Kamikubo, Nanaka Kaneshiro, Ryosuke Imaoka, Hao Jin, Taku Kashiyama, Yoshie Hashimoto, Masaru Kurosawa, Takashi Uehara, Nobuyuki Nukina, Takashi Sakurai

PLoS One. 2018; 13(8): e0200988. Published online 2018 Aug 7. doi: 10.1371/journal.pone.0200988

PMCID:: PMC6080755

Article PDF–1.9M

Select item 30895639.

Critical Role of the β-Subunit CDC50A in the Stable Expression, Assembly, Subcellular Localization, and Lipid Transport Activity of the P₄-ATPase ATP8A2

Jonathan A. Coleman, Robert S. Molday

J Biol Chem. 2011 May 13; 286(19): 17205–17216. Published online 2011 Mar 18. doi: 10.1074/jbc.M111.229419

PMCID:: PMC3089563

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Select item 838409110.

Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry

Shiyou Zhu, Ying Liu, Zhuo Zhou, Zhiying Zhang, Xia Xiao, Zhiheng Liu, Ang Chen, Xiaojing Dong, Feng Tian, Shihua Chen, Yiyuan Xu, Chunhui Wang, Qiheng Li, Xuran Niu, Qian Pan, Shuo Du, Junyu Xiao, Jianwei Wang, Wensheng Wei

Sci China Life Sci. 2022; 65(4): 701–717. Published online 2021 Aug 20. doi: 10.1007/s11427-021-1990-5

PMCID:: PMC8384091

Article PDF–4.3M

Select item 557122311.

Loss of Tmem30a leads to photoreceptor degeneration

Lin Zhang, Yeming Yang, Shujin Li, Shanshan Zhang, Xiong Zhu, Zhengfu Tai, Mu Yang, Yuqing Liu, Xinzheng Guo, Bo Chen, Zhilin Jiang, Fang Lu, Xianjun Zhu

Sci Rep. 2017; 7: 9296. Published online 2017 Aug 24. doi: 10.1038/s41598-017-09506-5

PMCID:: PMC5571223

Article PDF–7.1M

Select item 470539612.

Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium

Katsumori Segawa, Sachiko Kurata, Shigekazu Nagata

J Biol Chem. 2016 Jan 8; 291(2): 762–772. Published online 2015 Nov 13. doi: 10.1074/jbc.M115.690727

PMCID:: PMC4705396

Article PDF–2.8M

Select item 446344513.

Phospholipid Flippase ATP10A Translocates Phosphatidylcholine and Is Involved in Plasma Membrane Dynamics

Tomoki Naito, Hiroyuki Takatsu, Rie Miyano, Naoto Takada, Kazuhisa Nakayama, Hye-Won Shin

J Biol Chem. 2015 Jun 12; 290(24): 15004–15017. Published online 2015 May 6. doi: 10.1074/jbc.M115.655191

PMCID:: PMC4463445

Article PDF–4.2M

Select item 300335514.

CDC50 Proteins Are Critical Components of the Human Class-1 P₄-ATPase Transport Machinery

Susanne Bryde, Hanka Hennrich, Patricia M. Verhulst, Philippe F. Devaux, Guillaume Lenoir, Joost C. M. Holthuis

J Biol Chem. 2010 Dec 24; 285(52): 40562–40572. Published online 2010 Oct 20. doi: 10.1074/jbc.M110.139543

PMCID:: PMC3003355

Article PDF–2.4M

Select item 300099115.

Heteromeric Interactions Required for Abundance and Subcellular Localization of Human CDC50 Proteins and Class 1 P₄-ATPases

Lieke M. van der Velden, Catharina G. K. Wichers, Adriana E. D. van Breevoort, Jonathan A. Coleman, Robert S. Molday, Ruud Berger, Leo W. J. Klomp, Stan F. J. van de Graaf

J Biol Chem. 2010 Dec 17; 285(51): 40088–40096. Published online 2010 Oct 14. doi: 10.1074/jbc.M110.139006

PMCID:: PMC3000991

Article PDF–4.1M

Select item 357609616.

Role for Phospholipid Flippase Complex of ATP8A1 and CDC50A Proteins in Cell Migration

Utako Kato, Hironori Inadome, Masatoshi Yamamoto, Kazuo Emoto, Toshihide Kobayashi, Masato Umeda

J Biol Chem. 2013 Feb 15; 288(7): 4922–4934. Published online 2012 Dec 26. doi: 10.1074/jbc.M112.402701

PMCID:: PMC3576096

Article PDF–4.2M

Select item 556374317.

Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein

You Yu, Yinan Li, Yan Zhang

Neurosci Bull. 2016 Apr; 32(2): 171–176. Published online 2016 Mar 9. doi: 10.1007/s12264-016-0021-1

PMCID:: PMC5563743

Article PDF–873K

Select item 320747218.

ATP9B, a P4-ATPase (a Putative Aminophospholipid Translocase), Localizes to the trans-Golgi Network in a CDC50 Protein-independent Manner

Hiroyuki Takatsu, Keiko Baba, Takahiro Shima, Hiroyuki Umino, Utako Kato, Masato Umeda, Kazuhisa Nakayama, Hye-Won Shin

J Biol Chem. 2011 Nov 4; 286(44): 38159–38167. Published online 2011 Sep 13. doi: 10.1074/jbc.M111.281006

Correction in:: J Biol Chem. 2015 Jan 9; 290(2): 886.

PMCID:: PMC3207472

Article PDF–4.0M

Select item 670963519.

Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6

Brianna E. Talbot, David H. Vandorpe, Brian R. Stotter, Seth L. Alper, Johannes S. Schlondorff

J Biol Chem. 2019 Aug 23; 294(34): 12655–12669. Published online 2019 Jul 2. doi: 10.1074/jbc.RA119.008299

PMCID:: PMC6709635

Article PDF–2.5M

Select item 748475920.

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage

Marie-Christine Albert, Kerstin Brinkmann, Wojciech Pokrzywa, Saskia Diana Günther, Martin Krönke, Thorsten Hoppe, Hamid Kashkar

Cell Death Dis. 2020 Sep; 11(9): 740. Published online 2020 Sep 10. doi: 10.1038/s41419-020-02923-x

PMCID:: PMC7484759

Article PDF–2.6M

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