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Select item 79699541.

Pol α-primase dependent nuclear localization of the mammalian CST complex

Joseph M. Kelich, Harry Papaioannou, Emmanuel Skordalakes

Commun Biol. 2021; 4: 349. Published online 2021 Mar 17. doi: 10.1038/s42003-021-01845-4

PMCID:: PMC7969954

Article PDF–3.3M

Select item 59368032.

Activity and fidelity of human DNA polymerase α depend on primer structure

Andrey G. Baranovskiy, Vincent N. Duong, Nigar D. Babayeva, Yinbo Zhang, Youri I. Pavlov, Karen S. Anderson, Tahir H. Tahirov

J Biol Chem. 2018 May 4; 293(18): 6824–6843. Published online 2018 Mar 19. doi: 10.1074/jbc.RA117.001074

PMCID:: PMC5936803

Article PDF–4.8M

Select item 49174743.

Divalent ions attenuate DNA synthesis by human DNA polymerase α by changing the structure of the template/primer or by perturbing the polymerase reaction

Yinbo Zhang, Andrey G. Baranovskiy, Emin T. Tahirov, Tahir H. Tahirov, Youri I. Pavlov

DNA Repair (Amst) Author manuscript; available in PMC 2017 Jul 1.

Published in final edited form as: DNA Repair (Amst). 2016 Jul; 43: 24–33. Published online 2016 May 12. doi: 10.1016/j.dnarep.2016.05.017

PMCID:: PMC4917474

Article PDF–3.0M

Select item 48171314.

Human DNA polymerase α in binary complex with a DNA:DNA template-primer

Javier Coloma, Robert E. Johnson, Louise Prakash, Satya Prakash, Aneel K. Aggarwal

Sci Rep. 2016; 6: 23784. Published online 2016 Apr 1. doi: 10.1038/srep23784

PMCID:: PMC4817131

Article PDF–1.7M

Select item 45055025.

Crystal Structure of the Human Pol α B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit

Yoshiaki Suwa, Jianyou Gu, Andrey G. Baranovskiy, Nigar D. Babayeva, Youri I. Pavlov, Tahir H. Tahirov

J Biol Chem. 2015 Jun 5; 290(23): 14328–14337. Published online 2015 Apr 6. doi: 10.1074/jbc.M115.649954

PMCID:: PMC4505502

Article PDF–3.6M

Select item 25153186.

Human DNA Polymerase α Uses a Combination of Positive and Negative Selectivity to Polymerize Purine dNTPs with High Fidelity

Jeff Beckman, Kristi Kincaid, Michal Hocek, Thomas Spratt, Joachim Engels, Richard Cosstick, Robert D. Kuchta

Biochemistry. Author manuscript; available in PMC 2008 Aug 12.

Published in final edited form as: Biochemistry. 2007 Jan 16; 46(2): 448–460. doi: 10.1021/bi061243s

PMCID:: PMC2515318

Article PDF–1.5M

Select item 3905497.

Assignment of the gene for human DNA polymerase alpha to the X chromosome.

T S Wang, B E Pearson, H A Suomalainen, T Mohandas, L J Shapiro, J Schröder, D Korn

Proc Natl Acad Sci U S A. 1985 Aug; 82(16): 5270–5274. doi: 10.1073/pnas.82.16.5270

PMCID:: PMC390549

Summary Page Browse PDF–1003K

Select item 3598988.

Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase alpha-primase.

K L Collins, T J Kelly

Mol Cell Biol. 1991 Apr; 11(4): 2108–2115. doi: 10.1128/mcb.11.4.2108

PMCID:: PMC359898

Summary Page Browse PDF–1.7M

Select item 3598969.

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells.

B E Pearson, H P Nasheuer, T S Wang

Mol Cell Biol. 1991 Apr; 11(4): 2081–2095. doi: 10.1128/mcb.11.4.2081

PMCID:: PMC359896

Summary Page Browse PDF–3.0M

Select item 35896410.

Initiation of simian virus 40 DNA replication requires the interaction of a specific domain of human DNA polymerase alpha with large T antigen.

I Dornreiter, W C Copeland, T S Wang

Mol Cell Biol. 1993 Feb; 13(2): 809–820. doi: 10.1128/mcb.13.2.809

PMCID:: PMC358964

Summary Page Browse PDF–3.2M

Select item 33248611.

Human DNA polymerase alpha catalytic polypeptide binds ConA and RCA and contains a specific labile site in the N-terminus.

K L Hsi, W C Copeland, T S Wang

Nucleic Acids Res. 1990 Nov 11; 18(21): 6231–6237. doi: 10.1093/nar/18.21.6231

PMCID:: PMC332486

Summary Page Browse PDF–1.5M

Select item 31063912.

Fidelity of DNA synthesis catalyzed by human DNA polymerase alpha and HIV-1 reverse transcriptase: effect of reaction pH.

K A Eckert, T A Kunkel

Nucleic Acids Res. 1993 Nov 11; 21(22): 5212–5220. doi: 10.1093/nar/21.22.5212

PMCID:: PMC310639

Summary Page Browse PDF–1.7M

Select item 4125013.

Interaction of herpes simplex virus 1 origin-binding protein with DNA polymerase alpha.

S S Lee, Q Dong, T S Wang, I R Lehman

Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17): 7882–7886. doi: 10.1073/pnas.92.17.7882

PMCID:: PMC41250

Summary Page Browse PDF–1.3M

Select item 835509114.

Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini

Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Marcel Tijsterman

Nat Commun. 2021; 12: 4843. Published online 2021 Aug 10. doi: 10.1038/s41467-021-25154-w

PMCID:: PMC8355091

Article PDF–1.3M

Select item 650675715.

Defective DNA Polymerase α-Primase Leads to X-Linked Intellectual Disability Associated with Severe Growth Retardation, Microcephaly, and Hypogonadism

Hilde Van Esch, Rita Colnaghi, Kathleen Freson, Petro Starokadomskyy, Andreas Zankl, Liesbeth Backx, Iga Abramowicz, Emily Outwin, Luis Rohena, Claire Faulkner, Gary M. Leong, Ruth A. Newbury-Ecob, Rachel C. Challis, Katrin Õunap, Jacques Jaeken, Eve Seuntjens, Koen Devriendt, Ezra Burstein, Karen J. Low, Mark O’Driscoll

Am J Hum Genet. 2019 May 2; 104(5): 957–967. Published online 2019 Apr 18. doi: 10.1016/j.ajhg.2019.03.006

PMCID:: PMC6506757

Article PDF–1.5M

Select item 483696216.

DNA polymerase-a regulates type I interferon activation through cytosolic RNA:DNA synthesis

Petro Starokadomskyy, Terry Gemelli, Jonathan J. Rios, Chao Xing, Richard C. Wang, Haiying Li, Vladislav Pokatayev, Igor Dozmorov, Shaheen Khan, Naoteru Miyata, Guadalupe Fraile, Prithvi Raj, Zhe Xu, Zigang Xu, Lin Ma, Zhimiao Lin, Huijun Wang, Yong Yang, Dan Ben-Amitai, Naama Orenstein, Huda Mussaffi, Eulalia Baselga, Gianluca Tadini, Eyal Grunebaum, Adrijan Sarajlija, Konrad Krzewski, Edward K. Wakeland, Nan Yan, Maria Teresa de la Morena, Andrew R. Zinn, Ezra Burstein

Nat Immunol. Author manuscript; available in PMC 2016 Sep 28.

Published in final edited form as: Nat Immunol. 2016 May; 17(5): 495–504. Published online 2016 Mar 28. doi: 10.1038/ni.3409