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Select item 81371431.

Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

Adrian L Sanborn, Benjamin T Yeh, Jordan T Feigerle, Cynthia V Hao, Raphael JL Townshend, Erez Lieberman Aiden, Ron O Dror, Roger D Kornberg

eLife. 2021; 10: e68068. Published online 2021 Apr 27. doi: 10.7554/eLife.68068

PMCID:: PMC8137143

Article PDF–2.6M

Select item 79978802.

MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation

Cristina Batlle, Isabel Calvo, Valentin Iglesias, Cian J. Lynch, Marcos Gil-Garcia, Manuel Serrano, Salvador Ventura

Commun Biol. 2021; 4: 414. Published online 2021 Mar 26. doi: 10.1038/s42003-021-01930-8

PMCID:: PMC7997880

Article PDF–2.9M

Select item 45739963.

Differential expression of Mediator complex subunit MED15 in testicular germ cell tumors

Niklas Klümper, Isabella Syring, Anne Offermann, David Adler, Wenzel Vogel, Stefan C. Müller, Jörg Ellinger, Arne Strauß, Heinz Joachim Radzun, Philipp Ströbel, Johannes Brägelmann, Sven Perner, Felix Bremmer

Diagn Pathol. 2015; 10: 165. Published online 2015 Sep 17. doi: 10.1186/s13000-015-0398-6

PMCID:: PMC4573996

Article PDF–1.5M

Select item 68815884.

A Rare Partner of TFE3 in the Xp11 Translocation Renal Cell Carcinoma: Clinicopathological Analyses and Detection of MED15-TFE3 Fusion

Hong Ye, Shuming Qin, Ning Li, Min Lin, Yanmei Xu, Xiaomei Li

Biomed Res Int. 2019; 2019: 5974089. Published online 2019 Nov 11. doi: 10.1155/2019/5974089

PMCID:: PMC6881588

Article PDF–4.4M

Select item 53523745.

MED15 overexpression in prostate cancer arises during androgen deprivation therapy via PI3K/mTOR signaling

Anne Offermann, Ignacija Vlasic, Isabella Syring, Wenzel Vogel, Christian Ruiz, Tobias Zellweger, Cyrill A Rentsch, Susanne Hagedorn, Jochen Behrends, Michael Nowak, Axel Merseburger, Lukas Bubendorf, Jutta Kirfel, Stefan Duensing, David Adler, Sven Perner

Oncotarget. 2017 Jan 31; 8(5): 7964–7976. Published online 2016 Dec 10. doi: 10.18632/oncotarget.13860

PMCID:: PMC5352374

Article PDF–3.3M

Select item 28150836.

MODULATION OF PLAGL2 TRANSACTIVATION BY POSITIVE COFACTOR 2 (PC2), A COMPONENT OF THE ARC/MEDIATOR COMPLEX

Sara J. Wezensky, Tracey S. Hanks, Michelle J. Wilkison, Mary Cloud Ammons, Daniel W. Siemsen, Katherine A. Gauss

Gene. Author manuscript; available in PMC 2011 Feb 15.

Published in final edited form as: Gene. 2010 Feb 15; 452(1): 22. Published online 2009 Dec 16. doi: 10.1016/j.gene.2009.12.003

PMCID:: PMC2815083

Article PDF–2.4M

Select item 72423867.

MED15, transforming growth factor beta 1 (TGF-β1), FcγRIII (CD16), and HNK-1 (CD57) are prognostic biomarkers of oral squamous cell carcinoma

Maryam Elahi, Vahid Rakhshan

Sci Rep. 2020; 10: 8475. Published online 2020 May 21. doi: 10.1038/s41598-020-65145-3

PMCID:: PMC7242386

Article PDF–2.0M

Select item 34209478.

Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1

Spyros Petrakis, Tamás Raskó, Jenny Russ, Ralf P. Friedrich, Martin Stroedicke, Sean-Patrick Riechers, Katja Muehlenberg, Angeli Möller, Anita Reinhardt, Arunachalam Vinayagam, Martin H. Schaefer, Michael Boutros, Hervé Tricoire, Miguel A. Andrade-Navarro, Erich E. Wanker

PLoS Genet. 2012 Aug; 8(8): e1002897. Published online 2012 Aug 16. doi: 10.1371/journal.pgen.1002897

PMCID:: PMC3420947

Article PDF–2.3M

Select item 72060129.

TRIM11 facilitates chemoresistance in nasopharyngeal carcinoma by activating the β-catenin/ABCC9 axis via p62-selective autophagic degradation of Daple

Runa Zhang, Si-Wei Li, Lijuan Liu, Jun Yang, Guofu Huang, Yi Sang

Oncogenesis. 2020 May; 9(5): 45. Published online 2020 May 7. doi: 10.1038/s41389-020-0229-9

Correction in:: Oncogenesis. 2024 Dec; 13(1): 5.

PMCID:: PMC7206012

Article PDF–7.5M

Select item 35695210.

The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator

Fajun Yang, Rosalie DeBeaumont, Sharleen Zhou, Anders M. Näär

Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8): 2339–2344. Published online 2004 Feb 12. doi: 10.1073/pnas.0308676100

PMCID:: PMC356952

Article PDF–597K

Select item 377436511.

Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes

Taiki Tsutsui, Rikiya Fukasawa, Kaori Shinmyouzu, Reiko Nakagawa, Kazuyuki Tobe, Aki Tanaka, Yoshiaki Ohkuma

J Biol Chem. 2013 Jul 19; 288(29): 20955–20965. Published online 2013 Jun 9. doi: 10.1074/jbc.M113.486746

PMCID:: PMC3774365

Article PDF–1.5M

Select item 368142912.

HIF1A employs CDK8-Mediator to stimulate RNAPII elongation

Matthew D. Galbraith, Mary A. Allen, Claire L. Bensard, Xiaoxing Wang, Marie K. Schwinn, Bo Qin, Henry W. Long, Danette L. Daniels, William C. Hahn, Robin D. Dowell, Joaquín M. Espinosa

Cell. Author manuscript; available in PMC 2014 Jun 6.

Published in final edited form as: Cell. 2013 Jun 6; 153(6): 1327–1339. doi: 10.1016/j.cell.2013.04.048