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Select item 93735371.

Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification

Wenhao Chen, Yuxiang Lin, Meichen Jiang, Qingshui Wang, Qiang Shu

J Transl Med. 2022; 20: 355. Published online 2022 Aug 12. doi: 10.1186/s12967-022-03571-9

PMCID:: PMC9373537

Abstract Article PDF–7.1M

Select item 91330882.

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine

Kibum Kim, Hee Chan Yoo, Byung Gyu Kim, Sulhee Kim, Yulseung Sung, Ina Yoon, Ya Chun Yu, Seung Joon Park, Jong Hyun Kim, Kyungjae Myung, Kwang Yeon Hwang, Sunghoon Kim, Jung Min Han

Nat Commun. 2022; 13: 2904. Published online 2022 May 25. doi: 10.1038/s41467-022-30696-8

Correction in:: Nat Commun. 2022; 13: 6253.

PMCID:: PMC9133088

Abstract Article PDF–5.7M

Select item 72298423.

Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond

Ru-Juan Liu, Tao Long, Hao Li, JingHua Zhao, Jing Li, MingZhu Wang, Andrés Palencia, JinZhong Lin, Stephen Cusack, En-Duo Wang

Nucleic Acids Res. 2020 May 21; 48(9): 4946–4959. Published online 2020 Mar 30. doi: 10.1093/nar/gkaa189

PMCID:: PMC7229842

Abstract Article PDF–8.5M

Select item 44243574.

Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module

Wei Yan, Qing Ye, Min Tan, Xi Chen, Gilbert Eriani, En-Duo Wang

J Biol Chem. 2015 May 8; 290(19): 12256–12267. Published online 2015 Mar 27. doi: 10.1074/jbc.M115.639492

PMCID:: PMC4424357

Abstract Article PDF–1.4M

Select item 41886295.

Human tRNA Synthetase Catalytic Nulls with Diverse Functions

Wing-Sze Lo, Elisabeth Gardiner, Zhiwen Xu, Ching-Fun Lau, Feng Wang, Jie Zhou, John D. Mendlein, Leslie A. Nangle, Kyle P. Chiang, Xiang-Lei Yang, Kin-Fai Au, Wing Hung Wong, Min Guo, Mingjie Zhang, Paul Schimmel

Science. Author manuscript; available in PMC 2015 Jan 18.

Published in final edited form as: Science. 2014 Jul 18; 345(6194): 328–332. doi: 10.1126/science.1252943

PMCID:: PMC4188629

Abstract Article PDF–1.2M

Select item 41383276.

A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity

Qian Huang, Xiao-Long Zhou, Qin-Hua Hu, Hui-Yan Lei, Zhi-Peng Fang, Peng Yao, En-Duo Wang

RNA. 2014 Sep; 20(9): 1440–1450. doi: 10.1261/rna.044404.114

PMCID:: PMC4138327

Abstract Article PDF–919K

Select item 39279537.

The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells

Elena Perli, Carla Giordano, Annalinda Pisano, Arianna Montanari, Antonio F Campese, Aurelio Reyes, Daniele Ghezzi, Alessia Nasca, Helen A Tuppen, Maurizia Orlandi, Patrizio Di Micco, Elena Poser, Robert W Taylor, Gianni Colotti, Silvia Francisci, Veronica Morea, Laura Frontali, Massimo Zeviani, Giulia d'Amati

EMBO Mol Med. 2014 Feb; 6(2): 169–182. Published online 2014 Jan 10. doi: 10.1002/emmm.201303198

PMCID:: PMC3927953

Abstract Article PDF–1.2M

Select item 30176098.

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase

Xin Chen, Jing-Jing Ma, Min Tan, Peng Yao, Qing-Hua Hu, Gilbert Eriani, En-Duo Wang

Nucleic Acids Res. 2011 Jan; 39(1): 235–247. Published online 2010 Aug 30. doi: 10.1093/nar/gkq763

PMCID:: PMC3017609

Abstract Article PDF–2.7M

Select item 28717379.

A Paradigm Shift for the Amino Acid Editing Mechanism of Human Cytoplasmic Leucyl-tRNA Synthetase

Yan Ling Joy Pang, Susan A. Martinis

Biochemistry. Author manuscript; available in PMC 2010 Sep 29.

Published in final edited form as: Biochemistry. 2009 Sep 29; 48(38): 8958–8964. doi: 10.1021/bi901111y

PMCID:: PMC2871737

Abstract Article PDF–2.0M

Select item 267930410.

Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis

Seung-Hun Shin, Ho-Shik Kim, Seung-Hyun Jung, Hai-Dong Xu, Yong-Bok Jeong, Yeun-Jun Chung

Exp Mol Med. 2008 Apr 30; 40(2): 229–236. Published online 2008 Apr 20. doi: 10.3858/emm.2008.40.2.229

PMCID:: PMC2679304

Abstract Article PDF–1.5M

Select item 562207911.

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction

Jong Hyun Kim, Chulho Lee, Minji Lee, Haipeng Wang, Kibum Kim, Seung Joon Park, Ina Yoon, Jayun Jang, Hanchao Zhao, Hoi Kyoung Kim, Nam Hoon Kwon, Seung Jae Jeong, Hee Chan Yoo, Jae Hyun Kim, Jee Sun Yang, Myeong Youl Lee, Chang Woo Lee, Jieun Yun, Soo Jin Oh, Jong Soon Kang, Susan A. Martinis, Kwang Yeon Hwang, Min Guo, Gyoonhee Han, Jung Min Han, Sunghoon Kim

Nat Commun. 2017; 8: 732. Published online 2017 Sep 29. doi: 10.1038/s41467-017-00785-0

PMCID:: PMC5622079

Abstract Article PDF–2.0M

Select item 251806212.

A single residue in LeuRS affecting amino acid specificity and tRNA aminoacylation

Stanley W. Lue, Shana O. Kelley

Biochemistry. Author manuscript; available in PMC 2008 Aug 19.

Published in final edited form as: Biochemistry. 2007 Apr 17; 46(15): 4466–4472. Published online 2007 Mar 23. doi: 10.1021/bi0618215

PMCID:: PMC2518062

Abstract Article PDF–1.1M

Select item 36992113.

Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.

S Dana, J J Wasmuth

Mol Cell Biol. 1982 Oct; 2(10): 1220–1228. doi: 10.1128/mcb.2.10.1220

PMCID:: PMC369921

Summary Page Browse PDF–1.8M

Select item 1635914.

Genetic dissection of protein–protein interactions in multi-tRNA synthetase complex

Seung Bae Rho, Min Jung Kim, Jong Sang Lee, Wongi Seol, Hiromi Motegi, Sunghoon Kim, Kiyotaka Shiba

Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8): 4488–4493. doi: 10.1073/pnas.96.8.4488

PMCID:: PMC16359

Abstract Article PDF–187K

Select item 483837315.

The crystal structure of human GlnRS provides basis for the development of neurological disorders

Jana Ognjenović, Jiang Wu, Doreen Matthies, Ulrich Baxa, Sriram Subramaniam, Jiqiang Ling, Miljan Simonović

Nucleic Acids Res. 2016 Apr 20; 44(7): 3420–3431. Published online 2016 Feb 10. doi: 10.1093/nar/gkw082

PMCID:: PMC4838373

Abstract Article PDF–3.8M

Select item 964351416.

Regulation of BRCA1 stability through the tandem UBX domains of isoleucyl-tRNA synthetase 1

Scisung Chung, Mi-Sun Kang, Dauren S. Alimbetov, Gil-Im Mun, Na-Oh Yunn, Yunjin Kim, Byung-Gyu Kim, Minwoo Wie, Eun A. Lee, Jae Sun Ra, Jung-Min Oh, Donghyun Lee, Keondo Lee, Jihan Kim, Seung Hyun Han, Kyong-Tai Kim, Wan Kyun Chung, Ki Hyun Nam, Jaehyun Park, ByungHoon Lee, Sunghoon Kim, Weixing Zhao, Sung Ho Ryu, Yun-Sil Lee, Kyungjae Myung, Yunje Cho

Nat Commun. 2022; 13: 6732. Published online 2022 Nov 8. doi: 10.1038/s41467-022-34612-y

PMCID:: PMC9643514

Abstract Article PDF–2.1M

Select item 4466817.

Evolution of the Glx-tRNA synthetase family: the glutaminyl enzyme as a case of horizontal gene transfer.

V Lamour, S Quevillon, S Diriong, V C N'Guyen, M Lipinski, M Mirande

Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18): 8670–8674. doi: 10.1073/pnas.91.18.8670

PMCID:: PMC44668

Summary Page Browse PDF–1.5M

Select item 4441518.

Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit.

K Shiba, N Suzuki, K Shigesada, Y Namba, P Schimmel, T Noda

Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16): 7435–7439. doi: 10.1073/pnas.91.16.7435

PMCID:: PMC44415

Summary Page Browse PDF–1.7M

Select item 267947619.

Dynamic Organization of Aminoacyl-tRNA Synthetase Complexes in the Cytoplasm of Human Cells

Monika Kaminska, Svitlana Havrylenko, Paulette Decottignies, Pierre Le Maréchal, Boris Negrutskii, Marc Mirande

J Biol Chem. 2009 May 15; 284(20): 13746–13754. doi: 10.1074/jbc.M900480200

PMCID:: PMC2679476

Abstract Article PDF–569K

Select item 500801020.

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence

Romina Burla, Mariateresa Carcuro, Mattia La Torre, Federica Fratini, Marco Crescenzi, Maria Rosaria D'Apice, Paola Spitalieri, Grazia Daniela Raffa, Letizia Astrologo, Giovanna Lattanzi, Enrico Cundari, Domenico Raimondo, Annamaria Biroccio, Maurizio Gatti, Isabella Saggio

Open Biol. 2016 Aug; 6(8): 160103. Published online 2016 Aug 10. doi: 10.1098/rsob.160103

PMCID:: PMC5008010

Abstract Article PDF–1.4M

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PREDICTED: Mus musculus homologous recombination factor with OB-fold (Hrob), tra...
PREDICTED: Mus musculus homologous recombination factor with OB-fold (Hrob), transcript variant X7, mRNA
gi|1907081322|ref|XM_017314483.3|

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