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Items: 1 to 20 of 69

1.
Purine Nucleoside Phosphorylase Deficiency in Two Unrelated Patients with Autoimmune Hemolytic Anemia and Eosinophilia: Two Novel Mutations
Zahra Alizadeh, Mohsen Badalzadeh, Hanieh Heydarlou, Leila Shakerian, Maryam Mahlooji rad, Fariborz Zandieh, Mohammad Reza Fazlollahi
Arch Iran Med. 2023 Dec; 26(12): 712–716. Published online 2023 Dec 1. doi: 10.34172/aim.2023.105
PMCID:
PMC10915924
ArticlePDF–1.3M
2.
Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase
Clara F. Frost, Sree Ganesh Balasubramani, Dimitri Antoniou, Steven D. Schwartz
J Phys Chem B. Author manuscript; available in PMC 2024 Jan 12.
Published in final edited form as: J Phys Chem B. 2023 Jan 12; 127(1): 144–150. Published online 2022 Dec 20. doi: 10.1021/acs.jpcb.2c07243
PMCID:
PMC9873402
ArticlePDF–1.3M
3.
Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels
Rajesh K. Harijan, Ioanna Zoi, Dimitri Antoniou, Steven D. Schwartz, Vern L. Schramm
Proc Natl Acad Sci U S A. 2018 Jul 3; 115(27): E6209–E6216. Published online 2018 Jun 18. doi: 10.1073/pnas.1805416115
PMCID:
PMC6142206
ArticlePDF–1.1M
4.
Lupus-Associated Functional Polymorphism in PNP Causes Cell Cycle Abnormalities and Interferon Pathway Activation in Human Immune Cells
Yogita Ghodke-Puranik, Jessica M. Dorschner, Danielle M. Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Elias Eliopoulos, Maria I. Zervou, George N. Goulielmos, Mark A. Jensen, Timothy B. Niewold
Arthritis Rheumatol. Author manuscript; available in PMC 2018 Dec 1.
Published in final edited form as: Arthritis Rheumatol. 2017 Dec; 69(12): 2328–2337. Published online 2017 Nov 9. doi: 10.1002/art.40304
PMCID:
PMC5711527
ArticlePDF–1.1M
5.
Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase
Javier Suarez, Vern L. Schramm
Proc Natl Acad Sci U S A. 2015 Sep 8; 112(36): 11247–11251. Published online 2015 Aug 24. doi: 10.1073/pnas.1513956112
PMCID:
PMC4568649
ArticlePDF–960K
6.
The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning
Sergio Decherchi, Anna Berteotti, Giovanni Bottegoni, Walter Rocchia, Andrea Cavalli
Nat Commun. 2015 Jan 27; 6: 6155. Published online 2015 Jan 27. doi: 10.1038/ncomms7155
PMCID:
PMC4308819
ArticlePDF–2.0M
7.
Catalytic Site Conformations in Human PNP by 19F-NMR and Crystallography
Javier Suarez, Antti M. Haapalainen, Sean M. Cahill, Joseph Ho, Funing Yan, Steven C. Almo, Vern L. Schramm
Chem Biol. Author manuscript; available in PMC 2014 Feb 21.
Published in final edited form as: Chem Biol. 2013 Feb 21; 20(2): 212–222. doi: 10.1016/j.chembiol.2013.01.009
PMCID:
PMC3584414
ArticlePDF–3.3M
8.
Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase
Rafael G. Silva, Jennifer S. Hirschi, Mahmoud Ghanem, Andrew S. Murkin, Vern L. Schramm
Biochemistry. Author manuscript; available in PMC 2012 Apr 5.
Published in final edited form as: Biochemistry. 2011 Apr 5; 50(13): 2701–2709. Published online 2011 Mar 10. doi: 10.1021/bi200279s
PMCID:
PMC3070384
ArticlePDF–1.5M
9.
Metabolites of Purine Nucleoside Phosphorylase (NP) in Serum Have the Potential to Delineate Pancreatic Adenocarcinoma
Shaiju K. Vareed, Vadiraja B. Bhat, Christopher Thompson, Vihas T. Vasu, Damian Fermin, Hyungwon Choi, Chad J. Creighton, Sitaram Gayatri, Ling Lan, Nagireddy Putluri, Gagan Singh Thangjam, Punit Kaur, Mohsen Shabahang, Judith G. Giri, Alexey I. Nesvizhskii, Alexander A. A. Asea, Anil G. Cashikar, Arundhati Rao, James McLoughlin, Arun Sreekumar
PLoS One. 2011; 6(3): e17177. Published online 2011 Mar 23. doi: 10.1371/journal.pone.0017177
PMCID:
PMC3063153
ArticlePDF–2.1M
10.
Conformational States of Human Purine Nucleoside Phosphorylase at Rest, at Work and with Transition State Analogues
Achelle A. Edwards, Jeremiah D. Tipton, Michael D. Brenowitz, Mark R. Emmett, Alan G. Marshall, Gary B. Evans, Peter C. Tyler, Vern L. Schramm
Biochemistry. Author manuscript; available in PMC 2011 Mar 9.
Published in final edited form as: Biochemistry. 2010 Mar 9; 49(9): 2058–2067. doi: 10.1021/bi902041j
PMCID:
PMC2832846
ArticlePDF–6.7M
11.
Altered Enthalpy-Entropy Compensation in Picomolar Transition State Analogues of Human Purine Nucleoside Phosphorylase
Achelle A. Edwards, Jennifer M. Mason, Keith Clinch, Peter C. Tyler, Gary B. Evans, Vern L. Schramm
Biochemistry. Author manuscript; available in PMC 2010 Jun 16.
Published in final edited form as: Biochemistry. 2009 Jun 16; 48(23): 5226–5238. doi: 10.1021/bi9005896
PMCID:
PMC2711852
ArticlePDF–3.1M
12.
Loop Tryptophan Human PNP Reveals Submillisecond Protein Dynamics
Mahmoud Ghanem, Nickolay Zhadin, Robert Callender, Vern L. Schramm
Biochemistry. Author manuscript; available in PMC 2010 Apr 28.
Published in final edited form as: Biochemistry. 2009 Apr 28; 48(16): 3658–3668. doi: 10.1021/bi802339c
PMCID:
PMC2674222
ArticlePDF–1.9M
13.
Atomic detail of chemical transformation at the transition state of an enzymatic reaction
Suwipa Saen-oon, Sara Quaytman-Machleder, Vern L. Schramm, Steven D. Schwartz
Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43): 16543–16548. Published online 2008 Oct 22. doi: 10.1073/pnas.0808413105
PMCID:
PMC2575456
ArticlePDF–1.1M
14.
Molecular analysis of mutations in a patient with purine nucleoside phosphorylase deficiency.
M R Aust, L G Andrews, M J Barrett, C J Norby-Slycord, M L Markert
Am J Hum Genet. 1992 Oct; 51(4): 763–772.
PMCID:
PMC1682776
SummaryPage BrowsePDF–1.8M
15.
Sequence and functional characterization of the human purine nucleoside phosphorylase promoter.
J J Jonsson, S R Williams, R S McIvor
Nucleic Acids Res. 1991 Sep 25; 19(18): 5015–5020. doi: 10.1093/nar/19.18.5015
PMCID:
PMC328804
SummaryPage BrowsePDF–1.2M
16.
Human purine nucleoside phosphorylase cDNA sequence and genomic clone characterization.
S R Williams, J M Goddard, D W Martin, Jr
Nucleic Acids Res. 1984 Jul 25; 12(14): 5779–5787. doi: 10.1093/nar/12.14.5779
Correction in:
Nucleic Acids Res. 1984 Oct 25; 12(20): 7962.
PMCID:
PMC320030
SummaryPage BrowsePDF–873K
17.
A DNA enzyme with N-glycosylase activity
Terry L. Sheppard, Phillip Ordoukhanian, Gerald F. Joyce
Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14): 7802–7807. doi: 10.1073/pnas.97.14.7802
PMCID:
PMC16625
ArticlePDF–140K
18.
Four generations of transition-state analogues for human purine nucleoside phosphorylase
Meng-Chiao Ho, Wuxian Shi, Agnes Rinaldo-Matthis, Peter C. Tyler, Gary B. Evans, Keith Clinch, Steven C. Almo, Vern L. Schramm
Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11): 4805–4812. Published online 2010 Mar 8. doi: 10.1073/pnas.0913439107
PMCID:
PMC2841916
ArticlePDF–1.7M
19.
TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice
Ana Toro, Eyal Grunebaum
J Clin Invest. 2006 Oct 2; 116(10): 2717–2726. Published online 2006 Sep 7. doi: 10.1172/JCI25052
PMCID:
PMC1560347
ArticlePDF–832K
20.
Genetic variation in genes associated with arsenic metabolism: glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans.
Lizhi Yu, Kelly Kalla, Erin Guthrie, Amy Vidrine, Walter T Klimecki
Environ Health Perspect. 2003 Aug; 111(11): 1421–1427. doi: 10.1289/ehp.6420
PMCID:
PMC1241635
SummaryPDF–145K

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