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Select item 71360021.

Mechanical stretch increases Kv1.5 current through an interaction between the S1–S2 linker and N-terminus of the channel

Alexandria O. Milton, Tingzhong Wang, Wentao Li, Jun Guo, Shetuan Zhang

J Biol Chem. 2020 Apr 3; 295(14): 4723–4732. Published online 2020 Mar 2. doi: 10.1074/jbc.RA119.011302

PMCID:: PMC7136002

Article PDF–2.6M

Select item 70224462.

Challenges Faced with Small Molecular Modulators of Potassium Current Channel Isoform Kv1.5

Zefeng Zhao, Songsong Ruan, Xiaoming Ma, Qian Feng, Zhuosong Xie, Zhuang Nie, Peinan Fan, Mingcheng Qian, Xirui He, Shaoping Wu, Yongmin Zhang, Xiaohui Zheng

Biomolecules. 2020 Jan; 10(1): 10. Published online 2019 Dec 19. doi: 10.3390/biom10010010

PMCID:: PMC7022446

Article PDF–18M

Select item 61775903.

The N terminus and transmembrane segment S1 of Kv1.5 can coassemble with the rest of the channel independently of the S1–S2 linkage

Shawn M. Lamothe, Aja E. Hogan-Cann, Wentao Li, Jun Guo, Tonghua Yang, Jared N. Tschirhart, Shetuan Zhang

J Biol Chem. 2018 Oct 5; 293(40): 15347–15358. Published online 2018 Aug 17. doi: 10.1074/jbc.RA118.004065

PMCID:: PMC6177590

Article PDF–2.7M

Select item 54934294.

In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis

Michael A. Colman, Haibo Ni, Bo Liang, Nicole Schmitt, Henggui Zhang

PLoS Comput Biol. 2017 Jun; 13(6): e1005587. Published online 2017 Jun 16. doi: 10.1371/journal.pcbi.1005587

PMCID:: PMC5493429

Article PDF–13M

Select item 53412165.

Putative binding sites for arachidonic acid on the human cardiac K_v1.5 channel

Jia‐Yu Bai, Wei‐Guang Ding, Akiko Kojima, Tomoyoshi Seto, Hiroshi Matsuura

Br J Pharmacol. 2015 Nov; 172(22): 5281–5292. Published online 2015 Oct 22. doi: 10.1111/bph.13314

PMCID:: PMC5341216

Article PDF–2.1M

Select item 47160086.

Promoter Methylation Analysis Reveals that KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation

Katherine E Ryland, Allegra G. Hawkins, Daniel J. Weisenberger, Vasu Punj, Scott C. Borinstein, Peter W. Laird, Jeffrey R. Martens, Elizabeth R. Lawlor

Mol Cancer Res. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Mol Cancer Res. 2016 Jan; 14(1): 26–34. Published online 2015 Nov 16. doi: 10.1158/1541-7786.MCR-15-0343

PMCID:: PMC4716008

Article PDF–1.3M

Select item 46618607.

Silencing of Kv1.5 Gene Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells

Jin Wu, Zhida Chen, Qingjun Liu, Wenrong Zeng, Xinyu Wu, Bin Lin

Int J Mol Sci. 2015 Nov; 16(11): 26914–26926. Published online 2015 Nov 11. doi: 10.3390/ijms161126002

PMCID:: PMC4661860

Article PDF–6.2M

Select item 44514468.

Polycomb-Dependent Repression of the Potassium Channel-Encoding Gene KCNA5 Promotes Cancer Cell Survival Under Conditions of Stress

Katherine E Ryland, Laurie K. Svoboda, Eileen D Vesely, Jeremy C. McIntyre, Lian Zhang, Jeffrey R. Martens, Elizabeth R. Lawlor

Oncogene. Author manuscript; available in PMC 2016 Feb 27.

Published in final edited form as: Oncogene. 2015 Aug 27; 34(35): 4591–4600. Published online 2014 Dec 1. doi: 10.1038/onc.2014.384

PMCID:: PMC4451446

Article PDF–2.5M

Select item 44249109.

Remodeling of K_v1.5 Channel in Right Atria from Han Chinese Patients with Atrial Fibrillation

Xian-hong Ou, Miao-ling Li, Rui Liu, Xin-rong Fan, Liang Mao, Xue-hui Fan, Yan Yang, Xiao-rong Zeng

Med Sci Monit. 2015; 21: 1207–1213. Published online 2015 Apr 28. doi: 10.12659/MSM.893533

PMCID:: PMC4424910

Article PDF–368K

Select item 396398010.

Improved Functional Expression of Human Cardiac Kv1.5 Channels and Trafficking-Defective Mutants by Low Temperature Treatment

Wei-Guang Ding, Yu Xie, Futoshi Toyoda, Hiroshi Matsuura

PLoS One. 2014; 9(3): e92923. Published online 2014 Mar 24. doi: 10.1371/journal.pone.0092923

PMCID:: PMC3963980

Article PDF–1.4M

Select item 367459811.

KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor

Lara Bossini-Castillo, Carmen P Simeon, Lorenzo Beretta, Jasper Broen, Madelon C Vonk, José Luis Callejas, Patricia Carreira, Luis Rodríguez-Rodríguez, Rosa García-Portales, Miguel A González-Gay, Ivan Castellví, María Teresa Camps, Carlos Tolosa, Esther Vicente-Rabaneda, María Victoria Egurbide, Annemie J Schuerwegh, Roger Hesselstrand, Claudio Lunardi, Jacob M van Laar, Paul Shiels, Ariane Herrick, Jane Worthington, Christopher Denton, Timothy RDJ Radstake, Carmen Fonseca, Javier Martin

Arthritis Res Ther. 2012; 14(6): R273. Published online 2012 Dec 27. doi: 10.1186/ar4124

PMCID:: PMC3674598

Article PDF–209K

Select item 295694212.

Kinetic analysis of the effects of H⁺ or Ni²⁺ on Kv1.5 current shows that both ions enhance slow inactivation and induce resting inactivation

Yen May Cheng, David Fedida, Steven J Kehl

J Physiol. 2010 Aug 15; 588(Pt 16): 3011–3030. Published online 2010 Jun 25. doi: 10.1113/jphysiol.2010.191544

PMCID:: PMC2956942

Article PDF–944K

Select item 293279213.

A novel KCNA5 Mutation Implicates Tyrosine Kinase Signaling in Human Atrial Fibrillation

Tao Yang, Ping Yang, Dan M. Roden, Dawood Darbar

Heart Rhythm. Author manuscript; available in PMC 2010 Sep 3.

Published in final edited form as: Heart Rhythm. 2010 Sep; 7(9): 1246–1252. Published online 2010 Jun 1. doi: 10.1016/j.hrthm.2010.05.032

PMCID:: PMC2932792

Article PDF–1007K

Select item 283857714.

Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns

Elyssa D. Burg, Oleksandr Platoshyn, Igor F. Tsigelny, Beatriz Lozano-Ruiz, Brinda K. Rana, Jason X.-J. Yuan

Am J Physiol Cell Physiol. 2010 Mar; 298(3): C496–C509. Published online 2009 Dec 16. doi: 10.1152/ajpcell.00464.2009

PMCID:: PMC2838577

Article

Select item 263124715.

A pilot study to estimate the feasibility of assessing the relationships between polymorphisms in hKv1.5 and atrial fibrillation in patients following coronary artery bypass graft surgery

Isabelle Plante, Dominique Fournier, Patrick Mathieu, Pascal Daleau

Can J Cardiol. 2008 Jan; 24(1): 41–44. doi: 10.1016/s0828-282x(08)70546-4

PMCID:: PMC2631247

Article PDF–160K

Select item 258586516.

Kv Channel Gating Requires a Compatible S4-S5 Linker and Bottom Part of S6, Constrained by Non-interacting Residues

Alain J. Labro, Adam L. Raes, Alessandro Grottesi, Diane Van Hoorick, Mark S.P. Sansom, Dirk J. Snyders

J Gen Physiol. 2008 Dec; 132(6): 667–680. doi: 10.1085/jgp.200810048

PMCID:: PMC2585865

Article PDF–3.5M

Select item 221747917.

Coupling of Voltage Sensing to Channel Opening Reflects Intrasubunit Interactions in Kv Channels

Alain J. Labro, Adam L. Raes, Dirk J. Snyders

J Gen Physiol. 2005 Jan; 125(1): 71–80. doi: 10.1085/jgp.200409194

PMCID:: PMC2217479

Article PDF–1.9M

Select item 221733218.

Rapid Induction of P/C-type Inactivation Is the Mechanism for Acid-induced K⁺ Current Inhibition

Shetuan Zhang, Harley T. Kurata, Steven J. Kehl, David Fedida

J Gen Physiol. 2003 Mar; 121(3): 215–225. doi: 10.1085/jgp.20028760

PMCID:: PMC2217332

Article PDF–1.0M

Select item 786624719.

K_V1.5–K_Vβ1.3 Recycling Is PKC-Dependent

Alvaro Macias, Alicia de la Cruz, Diego A. Peraza, Angela de Benito-Bueno, Teresa Gonzalez, Carmen Valenzuela

Int J Mol Sci. 2021 Feb; 22(3): 1336. Published online 2021 Jan 29. doi: 10.3390/ijms22031336

PMCID:: PMC7866247

Article PDF–2.1M

Select item 770944420.

Selective expression of KCNA5 and KCNB1 genes in gastric and colorectal carcinoma

Azer Farah, Maria Kabbage, Salsabil Atafi, Amira Jaballah Gabteni, Mouadh Barbirou, Mouna Madhioub, Lamine Hamzaoui, Mousadak Azzouz Mohamed, Hassen Touinsi, Asma Ouakaa Kchaou, Emna Chelbi, Samir Boubaker, Rahma Ben Abderrazek, Balkiss Bouhaouala-Zahar

BMC Cancer. 2020; 20: 1179. Published online 2020 Dec 2. doi: 10.1186/s12885-020-07647-x

PMCID:: PMC7709444

Article PDF–1.3M

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