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Select item 94237381.

IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses

Shuai Shao, Lam C. Tsoi, William R. Swindell, Jiaoling Chen, Ranjitha Uppala, Allison C. Billi, Xianying Xing, Chang Zeng, Mrinal K. Sarkar, Rachael Wasikowski, Yanyun Jiang, Joseph Kirma, Jingru Sun, Olesya Plazyo, Gang Wang, Paul W. Harms, John J. Voorhees, Nicole L. Ward, Feiyang Ma, Matteo Pellegrini, Alexander Merleev, Bethany E. Perez White, Robert L. Modlin, Bogi Andersen, Emanual Maverakis, Stephan Weidinger, J. Michelle Kahlenberg, Johann E. Gudjonsson

J Invest Dermatol. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: J Invest Dermatol. 2021 Oct; 141(10): 2436–2448. Published online 2021 Apr 15. doi: 10.1016/j.jid.2021.03.019

PMCID:: PMC9423738

Abstract Article PDF–2.5M

Select item 91194342.

Multi-locus SNP analyses of interleukin 1 receptor associated kinases 2 gene polymorphisms with the susceptibility to rheumatoid arthritis

Maham Ghouri, Muhammad Ismail, Syeda Areesha Zaidi, Shafique Rehman, Asadullah Dahani, Saima Saleem, Sitwat Zehra

PLoS One. 2022; 17(5): e0268496. Published online 2022 May 19. doi: 10.1371/journal.pone.0268496

PMCID:: PMC9119434

Abstract Article PDF–877K

Select item 62058993.

Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer

Yinghui Xu, Hongliang Liu, Shun Liu, Yanru Wang, Jichun Xie, Thomas E. Stinchcombe, Li Su, Ruyang Zhang, David C. Christiani, Wei Li, Qingyi Wei

Int J Cancer. Author manuscript; available in PMC 2019 Nov 15.

Published in final edited form as: Int J Cancer. 2018 Nov 15; 143(10): 2400–2408. Published online 2018 Sep 21. doi: 10.1002/ijc.31660

PMCID:: PMC6205899

Abstract Article PDF–525K

Select item 41328104.

A Coding IRAK2 Protein Variant Compromises Toll-like receptor (TLR) Signaling and Is Associated with Colorectal Cancer Survival

Hui Wang, Sinead M. Flannery, Sabine Dickhöfer, Stefanie Huhn, Julie George, Andriy V. Kubarenko, Jesus Lascorz, Melanie Bevier, Joschka Willemsen, Tica Pichulik, Clemens Schafmayer, Marco Binder, Bénédicte Manoury, Søren R. Paludan, Marta Alarcon-Riquelme, Andrew G. Bowie, Asta Försti, Alexander N. R. Weber

J Biol Chem. 2014 Aug 15; 289(33): 23123–23131. Published online 2014 Jun 19. doi: 10.1074/jbc.M113.492934

PMCID:: PMC4132810

Abstract Article PDF–906K

Select item 31291495.

Human Interleukin-1 Receptor-associated Kinase-2 Is Essential for Toll-like Receptor-mediated Transcriptional and Post-transcriptional Regulation of Tumor Necrosis Factor α

Sinead M. Flannery, Sinead E. Keating, Joanna Szymak, Andrew G. Bowie

J Biol Chem. 2011 Jul 8; 286(27): 23688–23697. Published online 2011 May 23. doi: 10.1074/jbc.M111.248351

PMCID:: PMC3129149

Abstract Article PDF–1.9M

Select item 12201496.

Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB.

B Maschera, K Ray, K Burns, F Volpe

Biochem J. 1999 Apr 15; 339(Pt 2): 227–231.

PMCID:: PMC1220149

Summary PDF–159K

Select item 77072397.

Epigenetic silencing of microRNA-373 to epithelial-mesenchymal transition in non-small cell lung cancer through IRAK2 and LAMP1 axes

Hyang Sook Seol, Yoshimitsu Akiyama, Shu Shimada, Hee Jin Lee, Tae Im Kim, Sung Min Chun, Shree Ram Singh, Se Jin Jang

Cancer Lett. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Cancer Lett. 2014 Oct 28; 353(2): 232–241. Published online 2014 Jul 22. doi: 10.1016/j.canlet.2014.07.019

PMCID:: PMC7707239

Abstract Article PDF–1.7M

Select item 70548358.

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

Martin C. Moncrieffe, Daniel Bollschweiler, Bing Li, Pawel A. Penczek, Lee Hopkins, Clare E. Bryant, David Klenerman, Nicholas J. Gay

Structure. 2020 Mar 3; 28(3): 281–289.e3. doi: 10.1016/j.str.2020.01.003

PMCID:: PMC7054835

Abstract Article

Select item 40074449.

Interleukin-1 Receptor-associated Kinase-2 Genetic Variant rs708035 Increases NF-κB Activity through Promoting TRAF6 Ubiquitination

Weina Zhang, Tao He, Qiong Wang, Xin Li, Jianming Wei, Xiaoqiang Hou, Bin Zhang, Lei Huang, Li Wang

J Biol Chem. 2014 May 2; 289(18): 12507–12519. Published online 2014 Mar 24. doi: 10.1074/jbc.M113.538009

PMCID:: PMC4007444

Abstract Article PDF–2.7M

Select item 288869310.

Helical assembly in the MyD88:IRAK4:IRAK2 complex in TLR/IL-1R signaling

Su-Chang Lin, Yu-Chih Lo, Hao Wu

Nature. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Nature. 2010 Jun 17; 465(7300): 885–890. Published online 2010 May 19. doi: 10.1038/nature09121

PMCID:: PMC2888693

Abstract Article PDF–1.1M

Select item 221235911.

The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)

Marta Muzio, Gioacchino Natoli, Simona Saccani, Massimo Levrero, Alberto Mantovani

J Exp Med. 1998 Jun 15; 187(12): 2097–2101. doi: 10.1084/jem.187.12.2097

PMCID:: PMC2212359

Abstract Article PDF–228K

Select item 299811912.

Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

Jian Guo Cui, Yuan Yuan Li, Yuhai Zhao, Surjyadipta Bhattacharjee, Walter J. Lukiw

J Biol Chem. 2010 Dec 10; 285(50): 38951–38960. Published online 2010 Oct 11. doi: 10.1074/jbc.M110.178848

PMCID:: PMC2998119

Abstract Article PDF–2.5M

Select item 251689013.

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKɛ-mediated IRF activation

Martina Schröder, Marcin Baran, Andrew G Bowie

EMBO J. 2008 Aug 6; 27(15): 2147–2157. Published online 2008 Jul 17. doi: 10.1038/emboj.2008.143

PMCID:: PMC2516890

Abstract Article PDF–1.4M

Select item 366582614.

Interleukin-1 Receptor-Associated Kinase-2 (IRAK2) Is a Critical Mediator of Endoplasmic Reticulum (ER) Stress Signaling

Samir Benosman, Palaniyandi Ravanan, Ricardo G. Correa, Ying-Chen Hou, Minjia Yu, Muhammet Fatih Gulen, Xiaoxia Li, James Thomas, Michael Cuddy, Yasuko Matsuzawa, Renata Sano, Paul Diaz, Shu-ichi Matsuzawa, John C. Reed

PLoS One. 2013; 8(5): e64256. Published online 2013 May 28. doi: 10.1371/journal.pone.0064256

PMCID:: PMC3665826

Abstract Article PDF–1.7M

Select item 705466815.

RNF152 positively regulates TLR/IL‐1R signaling by enhancing MyD88 oligomerization

Mei‐Guang Xiong, Zhi‐Sheng Xu, Yu‐Hui Li, Su‐Yun Wang, Yan‐Yi Wang, Yong Ran

EMBO Rep. 2020 Mar 4; 21(3): e48860. Published online 2020 Jan 13. doi: 10.15252/embr.201948860

PMCID:: PMC7054668

Abstract Article PDF–1.2M

Select item 304867716.

Endotoxin Tolerance Impairs IL-1 Receptor-Associated Kinase (IRAK) 4 and TGF-β-activated Kinase 1 Activation, K63-linked Polyubiquitination and Assembly of IRAK1, TNF Receptor-associated Factor 6, and IκB Kinase γ and Increases A20 Expression

Yanbao Xiong, Fu Qiu, Wenji Piao, Chang Song, Larry M. Wahl, Andrei E. Medvedev

J Biol Chem. 2011 Mar 11; 286(10): 7905–7916. Published online 2011 Jan 10. doi: 10.1074/jbc.M110.182873

PMCID:: PMC3048677

Abstract Article PDF–2.3M

Select item 400444417.

The Tumor Necrosis Family Member 4-1BBL Sustains Inflammation by Interacting with Mediators of Toll-Like Receptor Signaling

Jianhui Ma, Bo-Ram Bang, Jiawei Lu, So-Young Eun, Motoyuki Otsuka, Michael Croft, Peter Tobias, Jiahuai Han, Osamu Takeuchi, Shizuo Akira, Michael Karin, Hideo Yagita, Young Jun Kang

Sci Signal. Author manuscript; available in PMC 2014 Apr 29.

Published in final edited form as: Sci Signal. 2013 Oct 1; 6(295): ra87. Published online 2013 Oct 1. doi: 10.1126/scisignal.2004431

PMCID:: PMC4004444

Abstract Article PDF–1.4M

Select item 320766318.

A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease

Jingran Zhou, Ruiqiong Wu, Anthony A. High, Clive A. Slaughter, David Finkelstein, Jerold E. Rehg, Vanessa Redecke, Hans Häcker

Proc Natl Acad Sci U S A. 2011 Nov 1; 108(44): E998–E1006. Published online 2011 Oct 19. doi: 10.1073/pnas.1106232108

PMCID:: PMC3207663

Abstract Article PDF–1.5M

Select item 315399819.

Genome-Wide Pleiotropy of Osteoporosis-Related Phenotypes: The Framingham Study

David Karasik, Yi-Hsiang Hsu, Yanhua Zhou, L Adrienne Cupples, Douglas P Kiel, Serkalem Demissie

J Bone Miner Res. 2010 Jul; 25(7): 1555–1563. Published online 2010 Jan 29. doi: 10.1002/jbmr.38

PMCID:: PMC3153998

Abstract Article PDF–158K

Select item 387065920.

HIV-1 gp120 impairs B cell proliferation by inducing TGF-ß1 production and FcRL4 expression

Katija Jelicic, Raffaello Cimbro, Fatima Nawaz, Da Wei Huang, Xin Zheng, Jun Yang, Richard A. Lempicki, Massimiliano Pascuccio, Donald Van Ryk, Catherine Schwing, Joseph Hiatt, Noreen Okwara, Danlan Wei, Gregg Roby, Antonio David, Young Hwang, II, John H. Kehrl, James Arthos, Claudia Cicala, Anthony S. Fauci

Nat Immunol. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Nat Immunol. 2013 Dec; 14(12): 1256–1265. Published online 2013 Oct 27. doi: 10.1038/ni.2746

PMCID:: PMC3870659

Abstract Article PDF–1.4M

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