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Select item 62654591.

Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment

Maxim Mogilevsky, Odelia Shimshon, Saran Kumar, Adi Mogilevsky, Eli Keshet, Eylon Yavin, Florian Heyd, Rotem Karni

Nucleic Acids Res. 2018 Nov 30; 46(21): 11396–11404. Published online 2018 Oct 17. doi: 10.1093/nar/gky921

PMCID:: PMC6265459

Article PDF–1.1M

Select item 55875552.

MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer

Zhihua Guo, Guilin Peng, Ermao Li, Shaoyan Xi, Yu Zhang, Yong Li, Xiaodong Lin, Guangqiu Li, Qinian Wu, Jianxing He

Sci Rep. 2017; 7: 10612. Published online 2017 Sep 6. doi: 10.1038/s41598-017-10397-9

PMCID:: PMC5587555

Article PDF–4.5M

Select item 42266953.

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

Frank Eckerdt, Elspeth Beauchamp, Jonathan Bell, Asneha Iqbal, Bing Su, Rikiro Fukunaga, Rishi R. Lulla, Stewart Goldman, Leonidas C. Platanias

Oncotarget. 2014 Sep; 5(18): 8442–8451. Published online 2014 Aug 6. doi: 10.18632/oncotarget.2319

PMCID:: PMC4226695

Article PDF–4.0M

Select item 23353464.

Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2

Blazej Dolniak, Efstratios Katsoulidis, Nathalie Carayol, Jessica K. Altman, Amanda J. Redig, Martin S. Tallman, Takeshi Ueda, Rie Watanabe-Fukunaga, Rikiro Fukunaga, Leonidas C. Platanias

J Biol Chem. 2008 May 2; 283(18): 12034–12042. doi: 10.1074/jbc.M708816200

PMCID:: PMC2335346

Article PDF–530K

Select item 475755.

Identification of additional members of human G-protein-coupled receptor kinase multigene family.

B Haribabu, R Snyderman

Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20): 9398–9402. doi: 10.1073/pnas.90.20.9398

PMCID:: PMC47575

Summary Page Browse PDF–1.3M

Select item 51181396.

Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion

Andrew K. Kwegyir-Afful, Robert D. Bruno, Puranik Purushottamachar, Francis N. Murigi, Vincent C. O. Njar

FEBS J. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: FEBS J. 2016 Nov; 283(21): 3898–3918. Published online 2016 Oct 1. doi: 10.1111/febs.13895

PMCID:: PMC5118139

Article PDF–2.3M

Select item 47513877.

Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5′-Terminal Cap and Hairpin

Nadejda L. Korneeva, Anren Song, Hermann Gram, Mary Ann Edens, Robert E. Rhoads

J Biol Chem. 2016 Feb 12; 291(7): 3455–3467. Published online 2015 Dec 14. doi: 10.1074/jbc.M115.694190

PMCID:: PMC4751387

Article PDF–1.7M

Select item 11936198.

Human Immunodeficiency Virus Type 1 Vpr-Dependent Cell Cycle Arrest through a Mitogen-Activated Protein Kinase Signal Transduction Pathway

Naoto Yoshizuka, Yuko Yoshizuka-Chadani, Vyjayanthi Krishnan, Steven L. Zeichner

J Virol. 2005 Sep; 79(17): 11366–11381. doi: 10.1128/JVI.79.17.11366-11381.2005

PMCID:: PMC1193619

Article PDF–877K

Select item 872729.

Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2

Ursula Knauf, Claude Tschopp, Hermann Gram

Mol Cell Biol. 2001 Aug; 21(16): 5500–5511. doi: 10.1128/MCB.21.16.5500-5511.2001

PMCID:: PMC87272

Article PDF–633K

Select item 789393610.

SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma

Hongda Liu, Zheng Gong, Kangshuai Li, Qun Zhang, Zekuan Xu, Yunfei Xu

J Exp Clin Cancer Res. 2021; 40: 75. Published online 2021 Feb 18. doi: 10.1186/s13046-021-01877-y

PMCID:: PMC7893936

Article PDF–7.5M

Select item 450984111.

Interferon-? regulates cellular metabolism and mRNA translation to potentiate macrophage activation

Xiaodi Su, Yingpu Yu, Yi Zhong, Eugenia G. Giannopoulou, Xiaoyu Hu, Hui Liu, Justin R. Cross, Gunnar Rätsch, Charles M. Rice, Lionel B. Ivashkiv

Nat Immunol. Author manuscript; available in PMC 2016 Feb 1.

Published in final edited form as: Nat Immunol. 2015 Aug; 16(8): 838–849. Published online 2015 Jun 29. doi: 10.1038/ni.3205

PMCID:: PMC4509841

Article PDF–1.9M

Select item 423804612.

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL

Ari L. Landon, Parameswary A. Muniandy, Amol C. Shetty, Elin Lehrmann, Laurent Volpon, Simone Houng, Yongqing Zhang, Bojie Dai, Raymond Peroutka, Krystyna Mazan-Mamczarz, James Steinhardt, Anup Mahurkar, Kevin G. Becker, Katherine L. Borden, Ronald B. Gartenhaus

Nat Commun. 2014 Nov 18; 5: 5413. Published online 2014 Nov 18. doi: 10.1038/ncomms6413

PMCID:: PMC4238046

Article PDF–3.3M

Select item 305783913.

Essential Role for Mnk Kinases in Type II Interferon (IFNγ) Signaling and Its Suppressive Effects on Normal Hematopoiesis

Sonali Joshi, Bhumika Sharma, Surinder Kaur, Beata Majchrzak, Takeshi Ueda, Rikiro Fukunaga, Amit K. Verma, Eleanor N. Fish, Leonidas C. Platanias

J Biol Chem. 2011 Feb 25; 286(8): 6017–6026. Published online 2010 Dec 13. doi: 10.1074/jbc.M110.197921

PMCID:: PMC3057839

Article PDF–2.3M

Select item 794664414.

MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma

Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark Edward Puhaindran, Peter Houghton, Angela Pang, Victor Kwanmin Lee, Ling-Wen Ding, Sigal Gery, Jeffrey Hill, Leilei Chen, Liang Xu, H. Phillip Koeffler

Oncogene. 2021; 40(10): 1851–1867. Published online 2021 Feb 9. doi: 10.1038/s41388-021-01661-4

PMCID:: PMC7946644

Article PDF–5.8M

Select item 374532815.

Essential Role for the Mnk Pathway in the Inhibitory Effects of Type I Interferons on Myeloproliferative Neoplasm (MPN) Precursors

Swarna Mehrotra, Bhumika Sharma, Sonali Joshi, Barbara Kroczynska, Beata Majchrzak, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Jonathan D. Licht, Darren P. Baker, Elizabeth A. Eklund, Amittha Wickrema, Amit Verma, Eleanor N. Fish, Leonidas C. Platanias

J Biol Chem. 2013 Aug 16; 288(33): 23814–23822. Published online 2013 Jun 28. doi: 10.1074/jbc.M113.476192

PMCID:: PMC3745328

Article PDF–1.5M

Select item 16635216.

The N and C Termini of the Splice Variants of the Human Mitogen-Activated Protein Kinase-Interacting Kinase Mnk2 Determine Activity and Localization

Gert C. Scheper, Josep L. Parra, Mary Wilson, Barbara van Kollenburg, Alfred C. O. Vertegaal, Ze-Guang Han, Christopher G. Proud

Mol Cell Biol. 2003 Aug; 23(16): 5692–5705. doi: 10.1128/MCB.23.16.5692-5705.2003

PMCID:: PMC166352

Article PDF–775K

Select item 8666617.

The Mitogen-Activated Protein Kinase Signal-Integrating Kinase Mnk2 Is a Eukaryotic Initiation Factor 4E Kinase with High Levels of Basal Activity in Mammalian Cells

Gert C. Scheper, Nick A. Morrice, Miranda Kleijn, Christopher G. Proud

Mol Cell Biol. 2001 Feb; 21(3): 743–754. doi: 10.1128/MCB.21.3.743-754.2001

PMCID:: PMC86666

Article PDF–1.8M

Select item 116979418.

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.

A J Waskiewicz, A Flynn, C G Proud, J A Cooper

EMBO J. 1997 Apr 15; 16(8): 1909–1920. doi: 10.1093/emboj/16.8.1909

PMCID:: PMC1169794

Summary PDF–792K

Select item 296748919.

A Human MAP Kinase Interactome

Sourav Bandyopadhyay, Chih-yuan Chiang, Jyoti Srivastava, Merril Gersten, Suhaila White, Russell Bell, Cornelia Kurschner, Christopher H. Martin, Mike Smoot, Sudhir Sahasrabudhe, Diane L. Barber, Sumit K. Chanda, Trey Ideker

Nat Methods. Author manuscript; available in PMC 2011 Apr 1.

Published in final edited form as: Nat Methods. 2010 Oct; 7(10): 801–805. doi: 10.1038/nmeth.1506

PMCID:: PMC2967489

Article PDF–1.2M

Select item 268304720.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67