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Select item 106960521.

Overexpressed Gαi1 exerts pro-tumorigenic activity in nasopharyngeal carcinoma

De-Pei Yin, Huanle Zhang, Hua Teng, Dan Zhang, Peipei Chen, Lixiao Xie, Ji-Sheng Liu

Cell Death Dis. 2023 Dec; 14(12): 792. Published online 2023 Dec 4. doi: 10.1038/s41419-023-06308-8

PMCID:: PMC10696052

Article PDF–6.4M

Select item 81071312.

Variants in GNAI1 Cause a Syndrome Associated with Variable Features including Developmental Delay, Seizures and Hypotonia

Alison M. Muir, Jennifer F. Gardner, Richard H. van Jaarsveld, Iris M. de Lange, Jasper J. van der Smagt, Golder N. Wilson, Holly Dubbs, Ethan M. Goldberg, Lia Zitano, Caleb Bupp, Jose Martinez, Myriam Srour, Andrea Accogli, Afnan Alhakeem, Meira Meltzer, Andrea Gropman, Carole Brewer, Richard C. Caswell, Tara Montgomery, Caoimhe McKenna, Shane McKee, Corinna Powell, Pradeep C. Vasudevan, Angela F. Brady, Shelagh Joss, Carolyn Tysoe, Grace Noh, Mark Tarnopolsky, Lauren Brady, Muhammad Zafar, Samantha A. Schrier Vergano, Brianna Murray, Lindsey Sawyer, Bryan E. Hainline, Katherine Sapp, Danielle DeMarzo, Darcy J. Huismann, Ingrid M. Wentzensen, Rhonda E. Schnur, Kristin G. Monaghan, Jane Juusola, Lindsay Rhodes, William B. Dobyns, Francois Lecoquierre, Alice Goldenberg, Tilman Polster, Susanne Axer-Schaefer, Konrad Platzer, Chiara Klöckner, Trevor L. Hoffman, Daniel G. MacArthur, Melanie C. O’Leary, Grace E. VanNoy, Eleina England, Vinod C. Varghese, Heather C. Mefford

Genet Med. Author manuscript; available in PMC 2021 Jul 20.

Published in final edited form as: Genet Med. 2021 May; 23(5): 881–887. Published online 2021 Jan 20. doi: 10.1038/s41436-020-01076-8

PMCID:: PMC8107131

Article PDF–908K

Select item 65365923.

Diagnostic Yield and Treatment Impact of Targeted Exome Sequencing in Early-Onset Epilepsy

Michelle Demos, Ilaria Guella, Conrado DeGuzman, Marna B. McKenzie, Sarah E. Buerki, Daniel M. Evans, Eric B. Toyota, Cyrus Boelman, Linda L. Huh, Anita Datta, Aspasia Michoulas, Kathryn Selby, Bruce H. Bjornson, Gabriella Horvath, Elena Lopez-Rangel, Clara D. M. van Karnebeek, Ramona Salvarinova, Erin Slade, Patrice Eydoux, Shelin Adam, Margot I. Van Allen, Tanya N. Nelson, Corneliu Bolbocean, Mary B. Connolly, Matthew J. Farrer

Front Neurol. 2019; 10: 434. Published online 2019 May 21. doi: 10.3389/fneur.2019.00434

PMCID:: PMC6536592

Article PDF–405K

Select item 50167004.

A Conserved Hydrophobic Core in Gα_i1 Regulates G Protein Activation and Release from Activated Receptor

Ali I. Kaya, Alyssa D. Lokits, James A. Gilbert, T. M. Iverson, Jens Meiler, Heidi E. Hamm

J Biol Chem. 2016 Sep 9; 291(37): 19674–19686. Published online 2016 Jul 26. doi: 10.1074/jbc.M116.745513

PMCID:: PMC5016700

Article PDF–2.3M

Select item 49329685.

Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding

David Goricanec, Ralf Stehle, Pascal Egloff, Simina Grigoriu, Andreas Plückthun, Gerhard Wagner, Franz Hagn

Proc Natl Acad Sci U S A. 2016 Jun 28; 113(26): E3629–E3638. Published online 2016 Jun 13. doi: 10.1073/pnas.1604125113

PMCID:: PMC4932968

Article PDF–3.1M

Select item 48769086.

Probing Gα_i1 Protein Activation at Single Amino Acid Resolution

Dawei Sun, Tilman Flock, Xavier Deupi, Shoji Maeda, Milos Matkovic, Sandro Mendieta, Daniel Mayer, Roger Dawson, Gebhard F.X. Schertler, M. Madan Babu, Dmitry B. Veprintsev

Nat Struct Mol Biol. Author manuscript; available in PMC 2016 May 23.

Published in final edited form as: Nat Struct Mol Biol. 2015 Sep; 22(9): 686–694. Published online 2015 Aug 10. doi: 10.1038/nsmb.3070

PMCID:: PMC4876908

Article PDF–2.8M

Select item 44980477.

Integration of Fourier Transform Infrared Spectroscopy, Fluorescence Spectroscopy, Steady-state Kinetics and Molecular Dynamics Simulations of Gα_i1 Distinguishes between the GTP Hydrolysis and GDP Release Mechanism

Grit Schröter, Daniel Mann, Carsten Kötting, Klaus Gerwert

J Biol Chem. 2015 Jul 10; 290(28): 17085–17095. Published online 2015 May 15. doi: 10.1074/jbc.M115.651190

PMCID:: PMC4498047

Article PDF–2.6M

Select item 41886008.

Mutation Analysis of Inhibitory Guanine Nucleotide Binding Protein Alpha (GNAI) Loci in Young and Familial Pituitary Adenomas

Hande Demir, Iikki Donner, Leena Kivipelto, Outi Kuismin, Camilla Schalin-Jäntti, Ernesto De Menis, Auli Karhu

PLoS One. 2014; 9(10): e109897. Published online 2014 Oct 7. doi: 10.1371/journal.pone.0109897

PMCID:: PMC4188600

Article PDF–4.4M

Select item 31583219.

Mu-Opioid Receptor Coupling to Gα_o Plays an Important Role in Opioid Antinociception

Jennifer T Lamberts, Emily M Jutkiewicz, Richard M Mortensen, John R Traynor

Neuropsychopharmacology. 2011 Sep; 36(10): 2041–2053. Published online 2011 Jun 8. doi: 10.1038/npp.2011.91

PMCID:: PMC3158321

Article PDF–768K

Select item 271932710.

Evidence for a Second, High Affinity Gβγ Binding Site on Gα_i1(GDP) Subunits

Jingting Wang, Parijat Sengupta, Yuanjian Guo, Urszula Golebiewska, Suzanne Scarlata

J Biol Chem. 2009 Jun 19; 284(25): 16906–16913. Published online 2009 Apr 15. doi: 10.1074/jbc.M109.006585

PMCID:: PMC2719327

Article PDF–625K

Select item 171519211.

The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.

D B Bloch, K D Bloch, M Iannuzzi, F S Collins, E J Neer, J G Seidman, C C Morton

Am J Hum Genet. 1988 Jun; 42(6): 884–888.

PMCID:: PMC1715192

Summary Page Browse PDF–834K

Select item 115149312.

Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets.

J M Gennity, W Siess

Biochem J. 1991 Nov 1; 279(Pt 3): 643–650. doi: 10.1042/bj2790643

PMCID:: PMC1151493

Summary Page Browse PDF–2.3M

Select item 29880413.

Human cDNA clones for an alpha subunit of Gi signal-transduction protein.

P Bray, A Carter, V Guo, C Puckett, J Kamholz, A Spiegel, M Nirenberg

Proc Natl Acad Sci U S A. 1987 Aug; 84(15): 5115–5119. doi: 10.1073/pnas.84.15.5115

PMCID:: PMC298804

Summary Page Browse PDF–1.1M

Select item 805421114.

Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

Yanyong Kang, Oleg Kuybeda, Parker W. de Waal, Somnath Mukherjee, Ned Van Eps, Przemyslaw Dutka, X. Edward Zhou, Alberto Bartesaghi, Satchal Erramilli, Takefumi Morizumi, Xin Gu, Yanting Yin, Ping Liu, Yi Jiang, Xing Meng, Gongpu Zhao, Karsten Melcher, Oliver P. Ernst, Anthony A. Kossiakoff, Sriram Subramaniam, H. Eric Xu

Nature. Author manuscript; available in PMC 2021 Apr 19.

Published in final edited form as: Nature. 2018 Jun; 558(7711): 553–558. Published online 2018 Jun 13. doi: 10.1038/s41586-018-0215-y

Correction in:: Nature. 2018 Jun 21

PMCID:: PMC8054211

Article PDF–5.1M

Select item 783317015.

Gα_i1 inhibition mechanism of ATP-bound adenylyl cyclase type 5

Daniele Narzi, Siri C. van Keulen, Ursula Röthlisberger

PLoS One. 2021; 16(1): e0245197. Published online 2021 Jan 25. doi: 10.1371/journal.pone.0245197

PMCID:: PMC7833170

Article PDF–2.7M

Select item 761122216.

Feeling at home: Structure of the NTSR1–G_i complex in a lipid environment

Jagannath Maharana, Arun K. Shukla

Nat Struct Mol Biol. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Nat Struct Mol Biol. 2021 Apr 1; 28(4): 331–333. doi: 10.1038/s41594-021-00581-x

PMCID:: PMC7611222

Article PDF–1.2M

Select item 706559317.

Conformational transitions of a neurotensin receptor 1–G_i1 protein complex

Hideaki E. Kato, Yan Zhang, Hongli Hu, Carl-Mikael Suomivuori, Francois Marie Ngako Kadji, Junken Aoki, Kaavya Krishna Kumar, Rasmus Fonseca, Daniel Hilger, Weijiao Huang, Naomi R. Latorraca, Asuka Inoue, Ron O. Dror, Brian K. Kobilka, Georgios Skiniotis

Nature. Author manuscript; available in PMC 2020 Mar 11.

Published in final edited form as: Nature. 2019 Aug; 572(7767): 80–85. Published online 2019 Jun 26. doi: 10.1038/s41586-019-1337-6

PMCID:: PMC7065593

Article PDF–4.9M

Select item 669790018.

Structural basis for GPCR-independent activation of heterotrimeric Gi proteins

Nicholas A. Kalogriopoulos, Steven D. Rees, Tony Ngo, Noah J. Kopcho, Andrey V. Ilatovskiy, Nina Sun, Elizabeth A. Komives, Geoffrey Chang, Pradipta Ghosh, Irina Kufareva

Proc Natl Acad Sci U S A. 2019 Aug 13; 116(33): 16394–16403. Published online 2019 Jul 30. doi: 10.1073/pnas.1906658116

Correction in:: Proc Natl Acad Sci U S A. 2019 Oct 8; 116(41): 20794.

PMCID:: PMC6697900

Article PDF–2.9M

Select item 631790419.

Structure of the μ Opioid Receptor-G_i Protein Complex

Antoine Koehl, Hongli Hu, Shoji Maeda, Yan Zhang, Qianhui Qu, Joseph M. Paggi, Naomi R. Latorraca, Daniel Hilger, Roger Dawson, Hugues Matile, Gebhard F. X. Schertler, Sebastien Granier, William I. Weis, Ron O. Dror, Aashish Manglik, Georgios Skiniotis, Brian K. Kobilka

Nature. Author manuscript; available in PMC 2019 Jan 3.

Published in final edited form as: Nature. 2018 Jun; 558(7711): 547–552. Published online 2018 Jun 13. doi: 10.1038/s41586-018-0219-7

PMCID:: PMC6317904

Article PDF–2.3M

Select item 579828920.

Activated heterotrimeric G protein α_i subunits inhibit Rap-dependent cell adhesion and promote cell migration

Jesi Y. To, Alan V. Smrcka

J Biol Chem. 2018 Feb 2; 293(5): 1570–1578. Published online 2017 Dec 19. doi: 10.1074/jbc.RA117.000964

PMCID:: PMC5798289

Article PDF–2.5M

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