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Select item 25973581.

Mutations in Fbx4 inhibit phosphorylation-dependent dimerization of the SCF^Fbx4 ligase and contribute to cyclin D1 overexpression in human cancer

Olena Barbash, Petia Zamfirova, Douglas I. Lin, Xiangmei Chen, Ke Yang, Hiroshi Nakagawa, Fengmin Lu, Anil K. Rustgi, J. Alan Diehl

Cancer Cell. Author manuscript; available in PMC 2009 Jul 8.

Published in final edited form as: Cancer Cell. 2008 Jul 8; 14(1): 68–78. doi: 10.1016/j.ccr.2008.05.017

PMCID:: PMC2597358

Article PDF–2.9M

Select item 60976152.

Structural Basis of Selective Ubiquitination of TRF1 by SCF^Fbx4

Zhixiong Zeng, Wei Wang, Yuting Yang, Yong Chen, Xiaomei Yang, J. Alan Diehl, Xuedong Liu, Ming Lei

Dev Cell. Author manuscript; available in PMC 2018 Aug 17.

Published in final edited form as: Dev Cell. 2010 Feb 16; 18(2): 214–225. doi: 10.1016/j.devcel.2010.01.007

PMCID:: PMC6097615

Article PDF–1.1M

Select item 27716973.

Heat shock factor 1 deficiency via its downstream target gene αB-crystallin (Hspb5) impairs p53 degradation

Xiongjie Jin, Demetrius Moskophidis, Yanzhong Hu, Andrew Phillips, Nahid F. Mivechi

J Cell Biochem. Author manuscript; available in PMC 2009 Nov 2.

Published in final edited form as: J Cell Biochem. 2009 Jun 1; 107(3): 504–515. doi: 10.1002/jcb.22151

PMCID:: PMC2771697

Article PDF–1.9M

Select item 96337294.

Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl

Nat Commun. 2022; 13: 6614. Published online 2022 Nov 3. doi: 10.1038/s41467-022-34402-6

PMCID:: PMC9633729

Article PDF–5.7M

Select item 59246985.

Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1

Rong Tan, Satoshi Nakajima, Qun Wang, Hongxiang Sun, Jing Xue, Jian Wu, Sabine Hellwig, Xuemei Zeng, Nathan A. Yates, Thomas E. Smithgall, Ming Lei, Yu Jiang, Arthur S. Levine, Bing Su, Li Lan

Mol Cell. Author manuscript; available in PMC 2018 Apr 29.

Published in final edited form as: Mol Cell. 2017 Mar 2; 65(5): 818–831.e5. Published online 2017 Feb 16. doi: 10.1016/j.molcel.2017.01.015

PMCID:: PMC5924698

Article PDF–1.2M

Select item 14469666.

The ETS Protein MEF Is Regulated by Phosphorylation-Dependent Proteolysis via the Protein-Ubiquitin Ligase SCF^Skp2

Yan Liu, Cyrus V. Hedvat, Shifeng Mao, Xin-Hua Zhu, Jinjuan Yao, Hoang Nguyen, Andrew Koff, Stephen D. Nimer

Mol Cell Biol. 2006 Apr; 26(8): 3114–3123. doi: 10.1128/MCB.26.8.3114-3123.2006

PMCID:: PMC1446966

Article PDF–403K

Select item 28595527.

Structural Basis of Dimerization-dependent Ubiquitination by the SCF^Fbx4 Ubiquitin Ligase

Yunfeng Li, Bing Hao

J Biol Chem. 2010 Apr 30; 285(18): 13896–13906. Published online 2010 Feb 24. doi: 10.1074/jbc.M110.111518

PMCID:: PMC2859552

Article PDF–3.3M

Select item 38381908.

The FBXO4 Tumor Suppressor Functions as a Barrier to Braf^V600E-Dependent Metastatic Melanoma

Eric K. Lee, Zhaorui Lian, Kurt D'Andrea, Richard Letrero, WeiQi Sheng, Shujing Liu, J. Nathaniel Diehl, Dariusz Pytel, Olena Barbash, Lynn Schuchter, Ravi Amaravaradi, Xiaowei Xu, Meenhard Herlyn, Katherine L. Nathanson, J. Alan Diehl

Mol Cell Biol. 2013 Nov; 33(22): 4422–4433. doi: 10.1128/MCB.00706-13

PMCID:: PMC3838190

Article PDF–1.9M

Select item 42517719.

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

Yongxing Gong, Travis Ian Zack, Luc G T Morris, Kan Lin, Ellen Hukkelhoven, Radhika Raheja, I-Li Tan, Sevin Turcan, Selvaraju Veeriah, Shasha Meng, Agnes Viale, Steven E Schumacher, Perry Palmedo, Rameen Beroukhim, Timothy A Chan

Nat Genet. Author manuscript; available in PMC 2014 Dec 2.

Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 588–594. Published online 2014 May 4. doi: 10.1038/ng.2981

PMCID:: PMC4251771

Article PDF–1.7M

Select item 323761510.

Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity

Yin Yin Choo, Boon Kim Boh, Jessica Jie Wei Lou, Jolane Eng, Yee Chin Leck, Benjamin Anders, Peter G. Smith, Thilo Hagen

Mol Biol Cell. 2011 Dec 15; 22(24): 4706–4715. doi: 10.1091/mbc.E11-03-0251

PMCID:: PMC3237615

Article PDF–1.1M

Select item 308432911.

Phosphorylation-dependent regulation of SCF^Fbx4 dimerization and activity involves a novel component, 14-3-3e

Olena Barbash, Eric K. Lee, J Alan Diehl

Oncogene. Author manuscript; available in PMC 2011 Oct 28.

Published in final edited form as: Oncogene. 2011 Apr 28; 30(17): 1995–2002. Published online 2011 Jan 17. doi: 10.1038/onc.2010.584

PMCID:: PMC3084329

Article PDF–1.2M

Select item 271158812.

GNL3L stabilizes the TRF1 complex and promotes mitotic transition

Qubo Zhu, Lingjun Meng, Joseph K. Hsu, Tao Lin, Jun Teishima, Robert Y.L. Tsai

J Cell Biol. 2009 Jun 1; 185(5): 827–839. doi: 10.1083/jcb.200812121

PMCID:: PMC2711588

Article PDF–7.5M

Select item 656758013.

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells

Zhou-hua Jiang, Tao Peng, Hai-long Qian, Cai-de Lu, Feng Qiu, Su-zhan Zhang

Cancer Cell Int. 2019; 19: 162. Published online 2019 Jun 14. doi: 10.1186/s12935-019-0878-y

PMCID:: PMC6567580

Article PDF–1.1M

Select item 310335814.

A Competitive Binding Mechanism between Skp1 and Exportin 1 (CRM1) Controls the Localization of a Subset of F-box Proteins

David E. Nelson, Heike Laman

J Biol Chem. 2011 Jun 3; 286(22): 19804–19815. Published online 2011 Mar 4. doi: 10.1074/jbc.M111.220079

PMCID:: PMC3103358

Article PDF–3.8M

Select item 170239015.

Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF^{FBX4-αBcrystallin} complex

Douglas I. Lin, Olena Barbash, K.G. Suresh Kumar, Jason D. Weber, J. Wade Harper, Andres J. P. Klein-Szanto, Anil Rustgi, Serge Y. Fuchs, J. Alan Diehl

Mol Cell. Author manuscript; available in PMC 2007 Nov 3.

Published in final edited form as: Mol Cell. 2006 Nov 3; 24(3): 355–366. doi: 10.1016/j.molcel.2006.09.007