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Select item 85097321.

Expression/Activation of PAR-1 in Airway Epithelial Cells of COPD Patients: Ex Vivo/In Vitro Study

Angela Marina Montalbano, Giuseppina Chiappara, Giusy Daniela Albano, Maria Ferraro, Caterina Di Sano, Patrizio Vitulo, Loredana Pipitone, Fabio Luigi Massimo Ricciardolo, Giulia Anzalone, Mirella Profita

Int J Mol Sci. 2021 Oct; 22(19): 10703. Published online 2021 Oct 2. doi: 10.3390/ijms221910703

PMCID:: PMC8509732

Article PDF–4.0M

Select item 66993682.

Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells

Anna Zhang, Yunfeng Hou, Chao Sun, Ying Pu, Yu Sun, Yuan Zhang, Yang Shen, Qingbo Zhou

Biomed Res Int. 2019; 2019: 2187306. Published online 2019 Aug 6. doi: 10.1155/2019/2187306

PMCID:: PMC6699368

Article PDF–1.5M

Select item 58467753.

Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients

Sabine Buhner, Hannes Hahne, Kerstin Hartwig, Qin Li, Sheila Vignali, Daniela Ostertag, Chen Meng, Gabriele Hörmannsperger, Breg Braak, Christian Pehl, Thomas Frieling, Giovanni Barbara, Roberto De Giorgio, Ihsan Ekin Demir, Güralp Onur Ceyhan, Florian Zeller, Guy Boeckxstaens, Dirk Haller, Bernhard Kuster, Michael Schemann

PLoS One. 2018; 13(3): e0193943. Published online 2018 Mar 12. doi: 10.1371/journal.pone.0193943

PMCID:: PMC5846775

Article PDF–2.8M

Select item 52972234.

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

Cong Lin, Christof J. Majoor, Joris J. T. H. Roelofs, Martijn D. de Kruif, Hugo M. Horlings, Keren Borensztajn, C. Arnold Spek

BMC Cancer. 2017; 17: 113. Published online 2017 Feb 7. doi: 10.1186/s12885-017-3081-3

PMCID:: PMC5297223

Article PDF–3.7M

Select item 48857965.

PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo

R Auvergne, C Wu, A Connell, S Au, A Cornwell, M Osipovitch, A Benraiss, S Dangelmajer, H Guerrero-Cazares, A Quinones-Hinojosa, SA Goldman

Oncogene. Author manuscript; available in PMC 2016 Jul 21.

Published in final edited form as: Oncogene. 2016 Jul 21; 35(29): 3817–3828. Published online 2015 Nov 30. doi: 10.1038/onc.2015.452

PMCID:: PMC4885796

Article PDF–2.3M

Select item 48368536.

Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease

Paul A. Gurbel, Kevin P. Bliden, Susan E. Turner, Udaya S. Tantry, Martin G. Gesheff, Travis P. Barr, Lidija Covic, Athan Kuliopulos

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Jan 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1): 189–197. doi: 10.1161/ATVBAHA.115.306777

PMCID:: PMC4836853

Article PDF–478K

Select item 47370937.

Role of a functional polymorphism in the F2R gene promoter in sarcoidosis

Manuela Platé, Phillippa J. Lawson, Michael R. Hill, Richard P. Marshall, Helen L. Booth, Meena Kumari, Geoffrey J. Laurent, John R. Hurst, Rachel C. Chambers

Respirology. 2015 Nov; 20(8): 1285–1287. Published online 2015 Aug 17. doi: 10.1111/resp.12608

PMCID:: PMC4737093

Article PDF–146K

Select item 46631348.

Down-Regulation of PAR1 Activity with a pHLIP-based Allosteric Antagonist Induces Cancer Cell Death

Kelly E. Burns, Damien Thévenin

Biochem J. Author manuscript; available in PMC 2016 Jun 15.

Published in final edited form as: Biochem J. 2015 Dec 15; 472(3): 287–295. Published online 2015 Sep 30. doi: 10.1042/BJ20150876

PMCID:: PMC4663134

Article PDF–683K

Select item 45054879.

Allosteric Activation of a G Protein-coupled Receptor with Cell-penetrating Receptor Mimetics

Ping Zhang, Andrew J. Leger, James D. Baleja, Rajashree Rana, Tiffany Corlin, Nga Nguyen, Georgios Koukos, Andrew Bohm, Lidija Covic, Athan Kuliopulos

J Biol Chem. 2015 Jun 19; 290(25): 15785–15798. Published online 2015 May 1. doi: 10.1074/jbc.M115.636316

PMCID:: PMC4505487

Article PDF–4.1M

Select item 449872210.

Expression of MMP-1/PAR-1 and patterns of invasion in oral squamous cell carcinoma as potential prognostic markers

Hai-Xia Fan, Yan Chen, Bo-Xiong Ni, Shan Wang, Miao Sun, Dong Chen, Jin-Hua Zheng

Onco Targets Ther. 2015; 8: 1619–1626. Published online 2015 Jul 3. doi: 10.2147/OTT.S84561

PMCID:: PMC4498722

Article PDF–2.7M

Select item 429342211.

PAR1-Activated Astrocytes in the Nucleus of the Solitary Tract Stimulate Adjacent Neurons via NMDA Receptors

Katie M. Vance, Richard C. Rogers, Gerlinda E. Hermann

J Neurosci. 2015 Jan 14; 35(2): 776–785. doi: 10.1523/JNEUROSCI.3105-14.2015

PMCID:: PMC4293422

Article PDF–1.0M

Select item 413716312.

Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations

Manuela Platé, Phillippa J. Lawson, Michael R. Hill, Jennifer K. Quint, Meena Kumari, Geoffrey J. Laurent, Jadwiga A. Wedzicha, Rachel C. Chambers, John R. Hurst

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15; 307(4): L311–L316. Published online 2014 Jun 27. doi: 10.1152/ajplung.00128.2014

PMCID:: PMC4137163

Article

Select item 399563213.

Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression

Yuji Ishibashi, Takanori Matsui, Seiji Ueda, Kei Fukami, Sho-ichi Yamagishi

Cardiovasc Diabetol. 2014; 13: 60. Published online 2014 Mar 13. doi: 10.1186/1475-2840-13-60

PMCID:: PMC3995632

Article PDF–920K

Select item 366874614.

Palmitoylation of Protease-activated Receptor-1 Regulates Adaptor Protein Complex-2 and -3 Interaction with Tyrosine-based Motifs and Endocytic Sorting

Isabel Canto, JoAnn Trejo

J Biol Chem. 2013 May 31; 288(22): 15900–15912. Published online 2013 Apr 11. doi: 10.1074/jbc.M113.469866

PMCID:: PMC3668746

Article PDF–2.7M

Select item 353187515.

High-resolution crystal structure of human Protease-Activated Receptor 1 bound to the antagonist vorapaxar

Cheng Zhang, Yoga Srinivasan, Daniel H. Arlow, Juan Jose Fung, Daniel Palmer, Yaowu Zheng, Hillary F. Green, Anjali Pandey, Ron O. Dror, David E. Shaw, William I. Weis, Shaun R. Coughlin, Brian K. Kobilka

Nature. Author manuscript; available in PMC 2013 Jun 20.

Published in final edited form as: Nature. 2012 Dec 20; 492(7429): 387–392. Published online 2012 Dec 9. doi: 10.1038/nature11701