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Select item 107867221.

Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity

Romain Larrue, Sandy Fellah, Benjamin Hennart, Naoual Sabaouni, Nihad Boukrout, Cynthia Van der Hauwaert, Clément Delage, Meyling Cheok, Michaël Perrais, Christelle Cauffiez, Delphine Allorge, Nicolas Pottier

Pharmacogenomics J. 2024; 24(1): 1. Published online 2024 Jan 12. doi: 10.1038/s41397-023-00322-x

PMCID:: PMC10786722

Article PDF–814K

Select item 102655962.

Impact of renal impairment on dihydropyrimidine dehydrogenase (DPD) phenotyping

B. Royer, M. Launay, J. Ciccolini, L. Derain, F. Parant, F. Thomas, J. Guitton

ESMO Open. 2023 Jun; 8(3): 101577. Published online 2023 May 31. doi: 10.1016/j.esmoop.2023.101577

PMCID:: PMC10265596

Article PDF–498K

Select item 101661673.

Allelic Frequency of DPYD Genetic Variants in Patients With Cancer in Spain: The PhotoDPYD Study

Marta Miarons, Alba Manzaneque Gordón, Pau Riera, Fernando Gutiérrez Nicolás, in Collaboration with the RedDPYD Research Group with the Spanish Society of Hospital Pharmacy (SEFH)

Oncologist. 2023 May; 28(5): e304–e308. Published online 2023 Apr 4. doi: 10.1093/oncolo/oyad077

PMCID:: PMC10166167

Article PDF–2.5M

Select item 101343044.

Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine‐induced toxicity in an Asian population

Masashi Kanai, Takahisa Kawaguchi, Masahito Kotaka, Dai Manaka, Junichi Hasegawa, Akinori Takagane, Yoshinori Munemoto, Takeshi Kato, Tetsuya Eto, Tetsuo Touyama, Takanori Matsui, Katsunori Shinozaki, Shigemi Matsumoto, Tsunekazu Mizushima, Masaki Mori, Junichi Sakamoto, Atsushi Ohtsu, Takayuki Yoshino, Shigetoyo Saji, Fumihiko Matsuda

Cancer Med. 2023 Apr; 12(7): 7808–7814. Published online 2022 Dec 16. doi: 10.1002/cam4.5541

PMCID:: PMC10134304

Article PDF–196K

Select item 98576855.

DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation

Theodore J. Wigle, Samantha Medwid, Cameron Ross, Ute I. Schwarz, Richard B. Kim

Curr Oncol. 2023 Jan; 30(1): 663–672. Published online 2023 Jan 4. doi: 10.3390/curroncol30010051

PMCID:: PMC9857685

Article PDF–427K

Select item 98103216.

Pharmacogenetic Study of the Dihydropyridine Dehydrogenase Gene in Jordanian Patients with Colorectal Cancer

Nusaiba A. Almashagbah, Amjad A. Mahasneh, Khaldon G. Bodoor

Asian Pac J Cancer Prev. 2022 Sep; 23(9): 3061–3069. doi: 10.31557/APJCP.2022.23.9.3061

PMCID:: PMC9810321

Article PDF–773K

Select item 88855587.

Consensus of experts from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines

P. García-Alfonso, M. Saiz-Rodríguez, R. Mondéjar, J. Salazar, D. Páez, A. M. Borobia, M. J. Safont, I. García-García, R. Colomer, X. García-González, M. J. Herrero, L. A. López-Fernández, F. Abad-Santos

Clin Transl Oncol. 2022; 24(3): 483–494. Published online 2021 Nov 13. doi: 10.1007/s12094-021-02708-4

PMCID:: PMC8885558

Article PDF–926K

Select item 86051728.

Dihydropyrimidine dehydrogenase (DPYD) gene c.1627A>G A/G and G/G genotypes are risk factors for lymph node metastasis and distant metastasis of colorectal cancer

Juanzi Zeng, Heming Wu, Qingyan Huang, Jiaquan Li, Zhikang Yu, Zhixiong Zhong

J Clin Lab Anal. 2021 Nov; 35(11): e24023. Published online 2021 Oct 6. doi: 10.1002/jcla.24023

PMCID:: PMC8605172

Article PDF–421K

Select item 83823049.

DPYD Genotyping in Patients Who Have Planned Cancer Treatment With Fluoropyrimidines: A Health Technology Assessment

Ontario Health (Quality)

Ont Health Technol Assess Ser. 2021; 21(14): 1–186. Published online 2021 Aug 12.

PMCID:: PMC8382304

Article PDF–2.6M

Select item 828373510.

DPYD, down-regulated by the potentially chemopreventive agent luteolin, interacts with STAT3 in pancreatic cancer

Hiroyuki Kato, Aya Naiki-Ito, Shugo Suzuki, Shingo Inaguma, Masayuki Komura, Kenju Nakao, Taku Naiki, Kenta Kachi, Akihisa Kato, Yoichi Matsuo, Satoru Takahashi

Carcinogenesis. 2021 Jul; 42(7): 940–950. Published online 2021 Feb 26. doi: 10.1093/carcin/bgab017

PMCID:: PMC8283735

Article PDF–20M

Select item 783188511.

Case report: severe toxicity in an African–American patient receiving FOLFOX carrying uncommon allelic variants in DPYD

Tristan M Sissung, Lisa Cordes, Cody J Peer, Shruti Gandhy, Jason Redman, Julius Strauss, William D Figg

Pharmacogenomics. 2021 Jan; 22(2): 81–85. Published online 2020 Dec 11. doi: 10.2217/pgs-2020-0120

PMCID:: PMC7831885

Article PDF–426K

Select item 729879812.

Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients

Reza Negarandeh, Ebrahim Salehifar, Fatemeh Saghafi, Hossein Jalali, Ghasem Janbabaei, Mohammad Javad Abdhaghighi, Anahita Nosrati

BMC Cancer. 2020; 20: 560. Published online 2020 Jun 16. doi: 10.1186/s12885-020-06904-3

PMCID:: PMC7298798

Article PDF–278K

Select item 699651513.

Fluorouracil sensitivity in a head and neck squamous cell carcinoma with a somatic DPYD structural variant

Elisa Majounie, Kathleen Wee, Laura M. Williamson, Martin R. Jones, Erin Pleasance, Howard J. Lim, Cheryl Ho, Daniel J. Renouf, Stephen Yip, Steven J.M. Jones, Marco A. Marra, Janessa Laskin

Cold Spring Harb Mol Case Stud. 2020 Feb; 6(1): a004713. doi: 10.1101/mcs.a004713

PMCID:: PMC6996515

Article PDF–2.0M

Select item 698268414.

Influence of DPYD*9A, DPYD*6 and GSTP1 ile105val Genetic Polymorphisms on Capecitabine and Oxaliplatin (CAPOX) Associated Toxicities in Colorectal Cancer (CRC) Patients

Ashok Varma K, M Jayanthi, Biswajit Dubashi, D G Shewade

Asian Pac J Cancer Prev. 2019; 20(10): 3093–3100. doi: 10.31557/APJCP.2019.20.10.3093

PMCID:: PMC6982684

Article PDF–405K

Select item 653321915.

Clinical implementation of pre-treatment DPYD genotyping in capecitabine-treated metastatic breast cancer patients

Chara Stavraka, Athanasios Pouptsis, Leroy Okonta, Karen DeSouza, Philip Charlton, Matthaios Kapiris, Anthony Marinaki, Eleni Karapanagiotou, Dionysis Papadatos-Pastos, Janine Mansi

Breast Cancer Res Treat. 2019; 175(2): 511–517. Published online 2019 Feb 12. doi: 10.1007/s10549-019-05144-9

PMCID:: PMC6533219

Article PDF–554K

Select item 592671816.

Germline Mutation of Dihydropyrimidine Dehydrogenese Gene among a Japanese Population in Relation to Toxicity to 5‐Fluorouracil

Kensei Yamaguchi, Yoshiko Aral, Yuzo Kanda, Kiwamu Akagi

Jpn J Cancer Res. 2001 Mar; 92(3): 337–342. doi: 10.1111/j.1349-7006.2001.tb01100.x

PMCID:: PMC5926718

Article PDF–522K

Select item 583363417.

Dihydropyrimidine dehydrogenase predicts survival and response to interferon-α in hepatocellular carcinoma

Wei-Ping Zhu, Ze-Yang Liu, Yi-Ming Zhao, Xi-Gan He, Qi Pan, Ning Zhang, Jia-Min Zhou, Long-Rong Wang, Miao Wang, Di-Hua Zhan, De-Ning Ma, Lu Wang

Cell Death Dis. 2018 Feb; 9(2): 69. Published online 2018 Jan 22. doi: 10.1038/s41419-017-0098-0

PMCID:: PMC5833634

Article PDF–3.6M

Select item 570967218.

Dihydropyrimidine dehydrogenase pharmacogenetics for predicting fluoropyrimidine-related toxicity in the randomised, phase III adjuvant TOSCA trial in high-risk colon cancer patients

A Ruzzo, F Graziano, Fabio Galli, Francesca Galli, E Rulli, S Lonardi, M Ronzoni, B Massidda, V Zagonel, N Pella, C Mucciarini, R Labianca, M T Ionta, I Bagaloni, E Veltri, P Sozzi, S Barni, V Ricci, L Foltran, M Nicolini, E Biondi, A Bramati, D Turci, S Lazzarelli, C Verusio, F Bergamo, A Sobrero, L Frontini, M Menghi, M Magnani

Br J Cancer. 2017 Oct 24; 117(9): 1269–1277. Published online 2017 Aug 24. doi: 10.1038/bjc.2017.289

PMCID:: PMC5709672

Article PDF–485K

Select item 550939919.

Investigation of IVS14+1G>A polymorphism of DPYD gene in a group of Bosnian patients treated with 5-fluorouracil and capecitabine

Timur Cerić, Nermina Obralić, Lejla Kapur-Pojskić, Draženka Macić, Semir Bešlija, Anes Pašić, Šejla Cerić

Bosn J Basic Med Sci. 2010 May; 10(2): 133–139. doi: 10.17305/bjbms.2010.2712

PMCID:: PMC5509399

Article PDF–212K

Select item 542176920.

New advances in DPYD genotype and risk of severe toxicity under capecitabine

Marie-Christine Etienne-Grimaldi, Jean-Christophe Boyer, Christophe Beroud, Litaty Mbatchi, André van Kuilenburg, Christine Bobin-Dubigeon, Fabienne Thomas, Etienne Chatelut, Jean-Louis Merlin, Frédéric Pinguet, Christophe Ferrand, Judith Meijer, Alexandre Evrard, Laurence Llorca, Gilles Romieu, Philippe Follana, Thomas Bachelot, Loic Chaigneau, Xavier Pivot, Véronique Dieras, Rémy Largillier, Mireille Mousseau, Anthony Goncalves, Henri Roché, Jacques Bonneterre, Véronique Servent, Nadine Dohollou, Yann Château, Emmanuel Chamorey, Jean-Pierre Desvignes, David Salgado, Jean-Marc Ferrero, Gérard Milano

PLoS One. 2017; 12(5): e0175998. Published online 2017 May 8. doi: 10.1371/journal.pone.0175998

PMCID:: PMC5421769

Article PDF–1.9M

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