PMC Links for Gene (Select 1548) - PMC

Alec W.R. Langlois, Ahmed El-Boraie, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Caryn Lerman, Jo Knight, Steven E. Scherer, Meghan J. Chenoweth, Rachel F. Tyndale

Pharmacogenet Genomics. Author manuscript; available in PMC 2023 Jun 1.

Published in final edited form as: Pharmacogenet Genomics. 2022 Jun 1; 32(4): 159–172. Published online 2022 Feb 21. doi: 10.1097/FPC.0000000000000466

PMCID:: PMC9081136

Article PDF–1.3M

Select item 87426414.

Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes

Ahmed El‐Boraie, Julie‐Anne Tanner, Andy Z.X. Zhu, Katrina G. Claw, Bhagwat Prasad, Erin G. Schuetz, Kenneth E. Thummel, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Caryn Lerman, Rachel F. Tyndale

Clin Transl Sci. 2022 Jan; 15(1): 204–220. Published online 2021 Sep 25. doi: 10.1111/cts.13135

PMCID:: PMC8742641

Article PDF–795K

Select item 87194505.

Roles of cytochrome P450 2A6 in the oxidation of flavone, 4´-hydroxyflavone, and 4´-, 3´-, and 2´-methoxyflavones by human liver microsomes

Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki, F. Peter Guengerich, Tsutomu Shimada

Xenobiotica. Author manuscript; available in PMC 2021 Dec 31.

Published in final edited form as: Xenobiotica. 2021 Sep; 51(9): 995–1009. Published online 2021 Aug 4. doi: 10.1080/00498254.2021.1950866

PMCID:: PMC8719450

Article PDF–1.5M

Select item 84697306.

Deciphering Structural Alterations Associated with Activity Reductions of Genetic Polymorphisms in Cytochrome P450 2A6 Using Molecular Dynamics Simulations

Koichi Kato, Tomoki Nakayoshi, Rika Nokura, Hiroki Hosono, Masahiro Hiratsuka, Yoshinobu Ishikawa, Eiji Kurimoto, Akifumi Oda

Int J Mol Sci. 2021 Sep; 22(18): 10119. Published online 2021 Sep 19. doi: 10.3390/ijms221810119

PMCID:: PMC8469730

Article PDF–8.6M

Select item 79312287.

Cytochrome P450 2A6 is associated with macrophage polarization and is a potential biomarker for hepatocellular carcinoma

Tao Jiang, Ai‐song Zhu, Chu‐qi Yang, Chu‐yun Xu, Dan‐qian Yang, Zhao‐huan Lou, Guang‐ji Zhang

FEBS Open Bio. 2021 Mar; 11(3): 670–683. Published online 2021 Feb 5. doi: 10.1002/2211-5463.13089

PMCID:: PMC7931228

Article PDF–5.7M

Select item 77930268.

Dissecting The Genetic Overlap Of Smoking Behaviors, Lung Cancer, And Chronic Obstructive Pulmonary Disease: A Focus On Nicotinic Receptors and Nicotine Metabolizing Enzyme

Michael J. Bray, Li-Shiun Chen, Louis Fox, Dana B. Hancock, Robert C. Culverhouse, Sarah M. Hartz, Eric O. Johnson, Mengzhen Liu, James D. McKay, Nancy L. Saccone, John E. Hokanson, Scott I. Vrieze, Rachel F. Tyndale, Timothy B. Baker, Laura J. Bierut

Genet Epidemiol. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: Genet Epidemiol. 2020 Oct; 44(7): 748–758. Published online 2020 Aug 16. doi: 10.1002/gepi.22331

PMCID:: PMC7793026

Article PDF–1.2M

Select item 75270279.

Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity

Ahmed El-Boraie, Taraneh Taghavi, Meghan J. Chenoweth, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Caryn Lerman, Nicole L. Nollen, Neal L. Benowitz, Rachel F. Tyndale

Addict Biol. Author manuscript; available in PMC 2020 Sep 30.

Published in final edited form as: Addict Biol. 2020 Jan; 25(1): e12741. Published online 2019 Feb 27. doi: 10.1111/adb.12741

PMCID:: PMC7527027

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Select item 705754910.

Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study

Maidina Abudushataer, Noriko Sato, Makiko Mieno, Motoji Sawabe, Masaaki Muramatsu, Tomio Arai

BMC Cancer. 2020; 20: 186. Published online 2020 Mar 4. doi: 10.1186/s12885-020-6663-4

PMCID:: PMC7057549

Article PDF–710K

Select item 643878011.

Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes

Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich, Tsutomu Shimada

Xenobiotica. Author manuscript; available in PMC 2019 Jul 1.

Published in final edited form as: Xenobiotica. 2019 Jul; 49(7): 791–802. Published online 2018 Sep 28. doi: 10.1080/00498254.2018.1505064

PMCID:: PMC6438780

Article PDF–3.9M

Select item 627425612.

In Vitro Assessment of CYP-Mediated Drug Interactions for Kinsenoside, an Antihyperlipidemic Candidate

Shaheed Ur Rehman, Min Sun Choi, In Sook Kim, Zengwei Luo, Yongbo Xue, Guangming Yao, Yonghui Zhang, Hye Hyun Yoo

Molecules. 2016 Jun; 21(6): 800. Published online 2016 Jun 18. doi: 10.3390/molecules21060800

PMCID:: PMC6274256

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Select item 624881913.

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Jian-Min Yuan, Heather H. Nelson, Steven G. Carmella, Renwei Wang, Jacquelyn Kuriger-Laber, Aizhen Jin, Jennifer Adams-Haduch, Stephen S. Hecht, Woon-Puay Koh, Sharon E. Murphy

Carcinogenesis. 2017 Apr; 38(4): 411–418. Published online 2017 Feb 9. doi: 10.1093/carcin/bgx012

PMCID:: PMC6248819

Article PDF–173K

Select item 610210114.

CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model

Kesheng Wang, Xue Chen, Stephen C. Ward, Ying Liu, Youssoufou Ouedraogo, Chun Xu, Arthur I. Cederbaum, Yongke Lu

Int J Obes (Lond) Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Int J Obes (Lond). 2019 Mar; 43(3): 475–486. Published online 2018 Feb 20. doi: 10.1038/s41366-018-0037-x

PMCID:: PMC6102101

Article PDF–2.3M

Select item 604720915.

Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2′,5′-Tetrachlorobiphenyl

Tsutomu Shimada, Kensaku Kakimoto, Shigeo Takenaka, Nobuyuki Koga, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki, Donghak Kim, F. Peter Guengerich, Masayuki Komori

Drug Metab Dispos. 2016 Dec; 44(12): 1899–1909. Published online 2016 Dec. doi: 10.1124/dmd.116.072991

PMCID:: PMC6047209

Article PDF–1.8M

Select item 593482716.

Association of genetic polymorphisms CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 with tobacco-induced lung Cancer: case-control study in an Egyptian population

Nada Ezzeldin, Dalia El-Lebedy, Amira Darwish, Ahmed El Bastawisy, Shereen Hamdy Abd Elaziz, Mirhane Mohamed Hassan, Amal Saad-Hussein

BMC Cancer. 2018; 18: 525. Published online 2018 May 3. doi: 10.1186/s12885-018-4342-5

PMCID:: PMC5934827

Article PDF–1.0M

Select item 580717917.

Genome-wide association study of a nicotine metabolism biomarker in African American smokers: impact of chromosome 19 genetic influences

Meghan J. Chenoweth, Jennifer J. Ware, Andy Z.X. Zhu, Christopher B. Cole, Lisa Sanderson Cox, Nikki Nollen, Jasjit S. Ahluwalia, Neal L. Benowitz, Robert A. Schnoll, Larry W. Hawk, Jr., Paul M. Cinciripini, Tony P. George, Caryn Lerman, Joanne Knight, Rachel F. Tyndale, on behalf of the PGRN-PNAT Research Group

Addiction. Author manuscript; available in PMC 2019 Mar 1.

Published in final edited form as: Addiction. 2018 Mar; 113(3): 509–523. Published online 2017 Nov 2. doi: 10.1111/add.14032

PMCID:: PMC5807179

Article PDF–1.0M

Select item 558279318.

CYP2A6 Polymorphisms Associate with Outcomes of S-1 Plus Oxaliplatin Chemotherapy in Chinese Gastric Cancer Patients

Lin Yang, Shanshan Zou, Chang Shu, Yan Song, Yong-Kun Sun, Wen Zhang, Aiping Zhou, Xinghua Yuan, Yi Yang, Songnian Hu

Genomics Proteomics Bioinformatics. 2017 Aug; 15(4): 255–262. Published online 2017 Aug 12. doi: 10.1016/j.gpb.2016.11.004

PMCID:: PMC5582793

Article PDF–892K

Select item 549136919.

CYP2A6 metabolism in the development of smoking behaviors in young adults

Emily Olfson, Joseph Bloom, Sarah Bertelsen, John P Budde, Naomi Breslau, Andrew Brooks, Robert Culverhouse, Grace Chan, Li-Shiun Chen, David Chorlian, Danielle M Dick, Howard J Edenberg, Sarah Hartz, Dorothy Hatsukami, Victor M Hesselbrock, Eric O Johnson, John R Kramer, Samuel Kuperman, Jacquelyn L Meyers, John Nurnberger, Jr, Bernice Porjesz, Nancy L Saccone, Marc A Schuckit, Jerry Stitzel, Jay A Tischfield, John P Rice, Alison Goate, Laura J Bierut

Addict Biol. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Addict Biol. 2018 Jan; 23(1): 437–447. Published online 2016 Dec 29. doi: 10.1111/adb.12477

PMCID:: PMC5491369

Article PDF–1.0M

Select item 544483720.

Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study

Sungshim L. Park, Sharon E. Murphy, Lynne R. Wilkens, Daniel O. Stram, Stephen S. Hecht, Loïc Le Marchand

PLoS One. 2017; 12(5): e0178435. Published online 2017 May 25. doi: 10.1371/journal.pone.0178435

PMCID:: PMC5444837

Article PDF–666K

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