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Select item 92784311.

U2 small nuclear RNA auxiliary factor 2, transcriptionally activated by the transcription factor Dp-1/E2F transcription factor 1 complex, enhances the growth and aerobic glycolysis of leiomyosarcoma cells

Yuguo Li, Sihao Chen, Xin Zhang, Naiqiang Zhuo

Bioengineered. 2022; 13(4): 10200–10212. Published online 2022 May 3. doi: 10.1080/21655979.2022.2061286

PMCID:: PMC9278431

Abstract Article PDF–6.6M

Select item 91283772.

Pre-mRNA splicing factor U2AF2 recognizes distinct conformations of nucleotide variants at the center of the pre-mRNA splice site signal

Eliezra Glasser, Debanjana Maji, Giulia Biancon, Anees Mohammed Keedakkatt Puthenpeedikakkal, Chapin E Cavender, Toma Tebaldi, Jermaine L Jenkins, David H Mathews, Stephanie Halene, Clara L Kielkopf

Nucleic Acids Res. 2022 May 20; 50(9): 5299–5312. Published online 2022 May 7. doi: 10.1093/nar/gkac287

PMCID:: PMC9128377

Abstract Article PDF–6.8M

Select item 78638933.

Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing

Debanjana Maji, Eliezra Glasser, Steven Henderson, Justin Galardi, Mary J. Pulvino, Jermaine L. Jenkins, Clara L. Kielkopf

J Biol Chem. 2020 Dec 11; 295(50): 17148–17157. Published online 2020 Oct 5. doi: 10.1074/jbc.RA120.015339

PMCID:: PMC7863893

Abstract Article PDF–2.8M

Select item 71322504.

An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

Hyun-Seo Kang, Carolina Sánchez-Rico, Stefanie Ebersberger, F. X. Reymond Sutandy, Anke Busch, Thomas Welte, Ralf Stehle, Clara Hipp, Laura Schulz, Andreas Buchbender, Kathi Zarnack, Julian König, Michael Sattler

Proc Natl Acad Sci U S A. 2020 Mar 31; 117(13): 7140–7149. Published online 2020 Mar 18. doi: 10.1073/pnas.1913483117

PMCID:: PMC7132250

Abstract Article PDF–1.9M

Select item 59326105.

In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors

F.X. Reymond Sutandy, Stefanie Ebersberger, Lu Huang, Anke Busch, Maximilian Bach, Hyun-Seo Kang, Jörg Fallmann, Daniel Maticzka, Rolf Backofen, Peter F. Stadler, Kathi Zarnack, Michael Sattler, Stefan Legewie, Julian König

Genome Res. 2018 May; 28(5): 699–713. doi: 10.1101/gr.229757.117

PMCID:: PMC5932610

Abstract Article PDF–2.2M

Select item 52043426.

Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs

Marta Melé, Kaia Mattioli, William Mallard, David M. Shechner, Chiara Gerhardinger, John L. Rinn

Genome Res. 2017 Jan; 27(1): 27–37. doi: 10.1101/gr.214205.116

PMCID:: PMC5204342

Abstract Article PDF–1.3M

Select item 47867847.

An extended U2AF⁶⁵–RNA-binding domain recognizes the 3′ splice site signal

Anant A. Agrawal, Enea Salsi, Rakesh Chatrikhi, Steven Henderson, Jermaine L. Jenkins, Michael R. Green, Dmitri N. Ermolenko, Clara L. Kielkopf

Nat Commun. 2016; 7: 10950. Published online 2016 Mar 8. doi: 10.1038/ncomms10950

PMCID:: PMC4786784

Abstract Article PDF–2.7M

Select item 45386328.

Splicing inhibition of U2AF⁶⁵ leads to alternative exon skipping

Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Ha Na Jang, Yongchao Liu, Jianhua Zhou, Takbum Ohn, Xuexiu Zheng, Haihong Shen

Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32): 9926–9931. Published online 2015 Jul 27. doi: 10.1073/pnas.1500639112

PMCID:: PMC4538632

Abstract Article PDF–1007K

Select item 42673909.

Structure-guided U2AF⁶⁵ variant improves recognition and splicing of a defective pre-mRNA

Anant A. Agrawal, Krystle J. McLaughlin, Jermaine L. Jenkins, Clara L. Kielkopf

Proc Natl Acad Sci U S A. 2014 Dec 9; 111(49): 17420–17425. Published online 2014 Nov 24. doi: 10.1073/pnas.1412743111

PMCID:: PMC4267390

Abstract Article PDF–873K

Select item 361674110.

U2AF⁶⁵ adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs

Jermaine L. Jenkins, Anant A. Agrawal, Ankit Gupta, Michael R. Green, Clara L. Kielkopf

Nucleic Acids Res. 2013 Apr; 41(6): 3859–3873. Published online 2013 Feb 1. doi: 10.1093/nar/gkt046

PMCID:: PMC3616741

Abstract Article PDF–15M

Select item 344798711.

A Broad Range of Conformations Contribute to the Solution Ensemble of the Essential Splicing Factor U2AF⁶⁵

Jermaine L. Jenkins, Kholiswa M. Laird, Clara L. Kielkopf

Biochemistry. Author manuscript; available in PMC 2013 Jul 3.

Published in final edited form as: Biochemistry. 2012 Jul 3; 51(26): 5223–5225. Published online 2012 Jun 19. doi: 10.1021/bi300277t

PMCID:: PMC3447987

Abstract Article PDF–911K

Select item 258624812.

Solution Conformation and Thermodynamic Characteristics of RNA Binding by the Splicing Factor U2AF⁶⁵

Jermaine L. Jenkins, Haihong Shen, Michael R. Green, Clara L. Kielkopf

J Biol Chem. 2008 Nov 28; 283(48): 33641–33649. doi: 10.1074/jbc.M806297200

PMCID:: PMC2586248

Abstract Article PDF–613K

Select item 221997513.

Crystallization and preliminary X-ray analysis of a U2AF⁶⁵ variant in complex with a polypyrimidine-tract analogue by use of protein engineering

E. Allen Sickmier, Katherine E. Frato, Clara L. Kielkopf

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1; 62(Pt 5): 457–459. Published online 2006 Apr 12. doi: 10.1107/S1744309106012504

PMCID:: PMC2219975

Abstract Article PDF–292K

Select item 182820614.

Alternative conformations at the RNA binding surface of the N-terminal U2AF⁶⁵ RNA recognition motif

Karen R. Thickman, E. Allen Sickmier, Clara L. Kielkopf.

J Mol Biol. Author manuscript; available in PMC 2007 Mar 17.

Published in final edited form as: J Mol Biol. 2007 Feb 23; 366(3): 703–710. Published online 2006 Dec 2. doi: 10.1016/j.jmb.2006.11.077

PMCID:: PMC1828206

Abstract Article PDF–879K

Select item 179458015.

Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors

Margarida Gama-Carvalho, Nuno L Barbosa-Morais, Alexander S Brodsky, Pamela A Silver, Maria Carmo-Fonseca

Genome Biol. 2006; 7(11): R113. Published online 2006 Nov 30. doi: 10.1186/gb-2006-7-11-r113

PMCID:: PMC1794580

Abstract Article PDF–566K

Select item 117152716.

Solution structures of the first and second RNA-binding domains of human U2 small nuclear ribonucleoprotein particle auxiliary factor (U2AF(65)).

T Ito, Y Muto, M R Green, S Yokoyama

EMBO J. 1999 Aug 16; 18(16): 4523–4534. doi: 10.1093/emboj/18.16.4523

PMCID:: PMC1171527

Summary PDF–1022K

Select item 108422617.

A novel function for the U2AF 65 splicing factor in promoting pre-mRNA 3′-end processing

Stefania Millevoi, Finola Geraghty, Bernadine Idowu, Jennifer L.Y. Tam, Michael Antoniou, Stéphan Vagner

EMBO Rep. 2002 Sep 16; 3(9): 869–874. doi: 10.1093/embo-reports/kvf173

PMCID:: PMC1084226

Abstract Article PDF–256K

Select item 27546518.

U2AF modulates poly(A) length control by the poly(A)-limiting element

Haidong Gu, Daniel R. Schoenberg

Nucleic Acids Res. 2003 Nov 1; 31(21): 6264–6271. doi: 10.1093/nar/gkg823

PMCID:: PMC275465

Abstract Article PDF–228K

Select item 936410719.

A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

Justin W. Galardi, Victoria N. Bela, Nazish Jeffery, Xueyang He, Eliezra Glasser, Sarah Loerch, Jermaine L. Jenkins, Mary J. Pulvino, Paul L. Boutz, Clara L. Kielkopf

J Biol Chem. 2022 Aug; 298(8): 102224. Published online 2022 Jul 1. doi: 10.1016/j.jbc.2022.102224