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Select item 109544521.

Site-specific acetylation of polynucleotide kinase 3′-phosphatase regulates its distinct role in DNA repair pathways

Azharul Islam, Anirban Chakraborty, Altaf H Sarker, Uma K Aryal, Lang Pan, Gulshan Sharma, Istvan Boldogh, Tapas Hazra

Nucleic Acids Res. 2024 Mar 21; 52(5): 2416–2433. Published online 2024 Jan 15. doi: 10.1093/nar/gkae002

PMCID:: PMC10954452

Article PDF–3.3M

Select item 101971072.

Functional analysis of a conserved site mutation in the DNA end processing enzyme PNKP leading to ataxia with oculomotor apraxia type 4 in humans

Azharul Islam, Anirban Chakraborty, Stefano Gambardella, Rosa Campopiano, Altaf H. Sarker, Istvan Boldogh, Tapas Hazra

J Biol Chem. 2023 May; 299(5): 104714. Published online 2023 Apr 13. doi: 10.1016/j.jbc.2023.104714

PMCID:: PMC10197107

Article PDF–2.2M

Select item 90931323.

Zika Virus Induces Mitotic Catastrophe in Human Neural Progenitors by Triggering Unscheduled Mitotic Entry in the Presence of DNA Damage While Functionally Depleting Nuclear PNKP

Malgorzata Rychlowska, Abigail Agyapong, Michael Weinfeld, Luis M. Schang

J Virol. 2022 May; 96(9): e00333-22. Published online 2022 Apr 12. doi: 10.1128/jvi.00333-22

PMCID:: PMC9093132

Article PDF–5.3M

Select item 77461934.

Mutational survivorship bias: The case of PNKP

Luis Bermúdez-Guzmán, Gabriel Jimenez-Huezo, Andrés Arguedas, Alejandro Leal

PLoS One. 2020; 15(12): e0237682. Published online 2020 Dec 17. doi: 10.1371/journal.pone.0237682

PMCID:: PMC7746193

Article PDF–4.3M

Select item 69595285.

Polynucleotide kinase 3′ phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial

Gwen Murphy, Leah S. Sansbury, Andrew W. Bergen, Zhuoqiao Wang, Arthur Schatzkin, Teresa Lehman, Aravind Kalidindi, Rama Modali, Elaine Lanza

Eur J Cancer Prev. Author manuscript; available in PMC 2020 Jan 14.

Published in final edited form as: Eur J Cancer Prev. 2008 Jun; 17(3): 287–290. doi: 10.1097/CEJ.0b013e3282b6fdb8

PMCID:: PMC6959528

Article PDF–308K

Select item 62808766.

The polynucleotide kinase 3′-phosphatase gene (PNKP) is involved in Charcot-Marie-Tooth disease (CMT2B2) previously related to MED25

Alejandro Leal, Sixto Bogantes-Ledezma, Arif B. Ekici, Steffen Uebe, Christian T. Thiel, Heinrich Sticht, Martin Berghoff, Corinna Berghoff, Bernal Morera, Michael Meisterernst, André Reis

Neurogenetics. 2018; 19(4): 215–225. Published online 2018 Jul 24. doi: 10.1007/s10048-018-0555-7

PMCID:: PMC6280876

Article PDF–3.9M

Select item 60500967.

Persistent 3′-phosphate termini and increased cytotoxicity of radiomimetic DNA double-strand breaks in cells lacking polynucleotide kinase/phosphatase despite presence of an alternative 3′-phosphatase

Sri Lakshmi Chalasani, Ajinkya S. Kawale, Konstantin Akopiants, Yaping Yu, Mesfin Fanta, Michael Weinfeld, Lawrence F. Povirk

DNA Repair (Amst) Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: DNA Repair (Amst). 2018 Aug; 68: 12–24. Published online 2018 May 26. doi: 10.1016/j.dnarep.2018.05.002

PMCID:: PMC6050096

Article PDF–1.0M

Select item 51617118.

Polynucleotide Kinase-Phosphatase (PNKP) Mutations and Neurologic Disease

Lavinia C. Dumitrache, Peter J. McKinnon

Mech Ageing Dev. Author manuscript; available in PMC 2017 Feb 18.

Published in final edited form as: Mech Ageing Dev. 2017 Jan; 161(Pt A): 121–129. Published online 2016 Apr 26. doi: 10.1016/j.mad.2016.04.009

PMCID:: PMC5161711

Article PDF–207K

Select item 43754499.

Mutations in PNKP Cause Recessive Ataxia with Oculomotor Apraxia Type 4

Jose Bras, Isabel Alonso, Clara Barbot, Maria Manuela Costa, Lee Darwent, Tatiana Orme, Jorge Sequeiros, John Hardy, Paula Coutinho, Rita Guerreiro

Am J Hum Genet. 2015 Mar 5; 96(3): 474–479. doi: 10.1016/j.ajhg.2015.01.005

PMCID:: PMC4375449

Article PDF–306K

Select item 341312710.

Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair

John J. Reynolds, Alexandra K. Walker, Edward C. Gilmore, Christopher A. Walsh, Keith W. Caldecott

Nucleic Acids Res. 2012 Aug; 40(14): 6608–6619. Published online 2012 Apr 14. doi: 10.1093/nar/gks318

PMCID:: PMC3413127

Article PDF–7.1M

Select item 324165611.

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage

Angela E. Zolner, Ismail Abdou, Ruiqiong Ye, Rajam S. Mani, Mesfin Fanta, Yaping Yu, Pauline Douglas, Nasser Tahbaz, Shujuan Fang, Tracey Dobbs, Chen Wang, Nick Morrice, Michael J. Hendzel, Michael Weinfeld, Susan P. Lees-Miller

Nucleic Acids Res. 2011 Nov; 39(21): 9224–9237. Published online 2011 Aug 8. doi: 10.1093/nar/gkr647

PMCID:: PMC3241656

Article PDF–4.7M

Select item 283598412.

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

Jun Shen, Edward C. Gilmore, Christine A. Marshall, Mary Haddadin, John J. Reynolds, Wafaa Eyaid, Adria Bodell, Kathryn Allen, Bernard S. Chang, Arthur Grix, R. Sean Hill, Meral Topcu, Keith W. Caldecott, A. James Barkovich, Christopher A. Walsh

Nat Genet. Author manuscript; available in PMC 2010 Sep 1.

Published in final edited form as: Nat Genet. 2010 Mar; 42(3): 245–249. Published online 2010 Jan 31. doi: 10.1038/ng.526

PMCID:: PMC2835984

Article PDF–1.1M

Select item 733793413.

Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair

Ilona Kalasova, Richard Hailstone, Janin Bublitz, Jovel Bogantes, Winfried Hofmann, Alejandro Leal, Hana Hanzlikova, Keith W Caldecott

Nucleic Acids Res. 2020 Jul 9; 48(12): 6672–6684. Published online 2020 Jun 6. doi: 10.1093/nar/gkaa489

PMCID:: PMC7337934

Article PDF–5.3M

Select item 633388914.

Domain analysis of PNKP–XRCC1 interactions: Influence of genetic variants of XRCC1

Rajam S. Mani, Inbal Mermershtain, Ismail Abdou, Mesfin Fanta, Michael J. Hendzel, J. N. Mark Glover, Michael Weinfeld

J Biol Chem. 2019 Jan 11; 294(2): 520–530. Published online 2018 Nov 16. doi: 10.1074/jbc.RA118.004262

PMCID:: PMC6333889

Article PDF–1.2M

Select item 562503515.

The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair

Claire Breslin, Rajam S. Mani, Mesfin Fanta, Nicolas Hoch, Michael Weinfeld, Keith W. Caldecott

J Biol Chem. 2017 Sep 29; 292(39): 16024–16031. Published online 2017 Aug 16. doi: 10.1074/jbc.M117.806638

PMCID:: PMC5625035

Article PDF–1.4M

Select item 379390216.

Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase

Todd R. Mereniuk, Mohamed A.M. El Gendy, Ana M. Mendes-Pereira, Christopher J. Lord, Sunita Ghosh, Edan Foley, Alan Ashworth, Michael Weinfeld

Mol Cancer Ther. Author manuscript; available in PMC 2014 Apr 1.

Published in final edited form as: Mol Cancer Ther. 2013 Oct; 12(10): 2135–2144. Published online 2013 Jul 24. doi: 10.1158/1535-7163.MCT-12-1093

PMCID:: PMC3793902

Article PDF–2.3M

Select item 349396317.

The Interaction between Polynucleotide Kinase Phosphatase and the DNA Repair Protein XRCC1 Is Critical for Repair of DNA Alkylation Damage and Stable Association at DNA Damage Sites

Julie Della-Maria, Muralidhar L. Hegde, Daniel R. McNeill, Yoshihiro Matsumoto, Miaw-Sheue Tsai, Tom Ellenberger, David M. Wilson, III, Sankar Mitra, Alan E. Tomkinson

J Biol Chem. 2012 Nov 9; 287(46): 39233–39244. Published online 2012 Sep 19. doi: 10.1074/jbc.M112.369975

PMCID:: PMC3493963

Article PDF–2.7M

Select item 326843918.

Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome

Santi M. Mandal, Muralidhar L. Hegde, Arpita Chatterjee, Pavana M. Hegde, Bartosz Szczesny, Dibyendu Banerjee, Istvan Boldogh, Rui Gao, Maria Falkenberg, Claes M. Gustafsson, Partha S. Sarkar, Tapas K. Hazra

J Biol Chem. 2012 Jan 20; 287(4): 2819–2829. Published online 2011 Nov 30. doi: 10.1074/jbc.M111.272179

PMCID:: PMC3268439

Article PDF–3.3M

Select item 324854119.

Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates

Nicolas Coquelle, Zahra Havali-Shahriari, Nina Bernstein, Ruth Green, J. N. Mark Glover

Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52): 21022-21027. Published online 2011 Dec 14. doi: 10.1073/pnas.1112036108

PMCID:: PMC3248541

Article PDF–1.7M

Select item 298836720.

Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase: IMPLICATIONS FOR NONHOMOLOGOUS END JOINING

Rajam S. Mani, Yaping Yu, Shujuan Fang, Meiling Lu, Mesfin Fanta, Angela E. Zolner, Nasser Tahbaz, Dale A. Ramsden, David W. Litchfield, Susan P. Lees-Miller, Michael Weinfeld

J Biol Chem. 2010 Nov 26; 285(48): 37619–37629. Published online 2010 Sep 17. doi: 10.1074/jbc.M109.058719