U.S. flag

An official website of the United States government

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Links from Gene

Items: 1 to 20 of 34

1.
NPRL2 down‐regulation facilitates the growth of hepatocellular carcinoma via the mTOR pathway and autophagy suppression
Ya‐Chin Wang, Ming‐Chao Tsai, Yaw‐Sen Chen, Pei‐Min Hsieh, Chao‐Ming Hung, Hung‐Yu Lin, Yao‐Chun Hsu, Jen‐Hao Yeh, Pojen Hsiao, Yu‐Cheih Su, Ching‐Hou Ma, Chih‐Yuan Lee, Chih‐Che Lin, Chih‐Wen Shu, Yu‐Chan Li, Mei‐Hsing Tsai, James Yu Lin, Wei‐Hao Peng, Ming‐Lung Yu, Chih‐Wen Lin
Hepatol Commun. 2022 Dec; 6(12): 3563–3577. Published online 2022 Nov 2. doi: 10.1002/hep4.2019
PMCID:
PMC9701468
ArticlePDF–3.0M
2.
A splicing variation in NPRL2 causing familial focal epilepsy with variable foci: additional cases and literature review
Jia Zhang, Yajun Shen, Zuozhen Yang, Fan Yang, Yang Li, Bo Yu, Wanlin Chen, Jing Gan
J Hum Genet. 2022; 67(2): 79–85. Published online 2021 Aug 11. doi: 10.1038/s10038-021-00969-z
PMCID:
PMC8786660
ArticlePDF–1.1M
3.
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway
Shasha Liu, Bingrong Liu
Med Sci Monit. 2018; 24: 1424–1433. Published online 2018 Mar 9. doi: 10.12659/MSM.909186
PMCID:
PMC5857147
ArticlePDF–3.4M
4.
Tumor suppressor NPRL2 induces ROS production and DNA damage response
Yinxing Ma, Licia Silveri, John LaCava, Svetlana Dokudovskaya
Sci Rep. 2017; 7: 15311. Published online 2017 Nov 10. doi: 10.1038/s41598-017-15497-0
PMCID:
PMC5681675
ArticlePDF–7.7M
5.
Relationship between tumor and peripheral blood NPRL2 mRNA levels in patients with colorectal adenoma and colorectal cancer
Ai-yun Liu, Dian-gang Liu, Ya-ju Du, Feng-hua Pei, Guang Yang, Bing-rong Liu, Hui-tao Zhang, Xin-hong Wang, Yu-jing Fan, Ying-zhun Chen, Yang Jiang, Jing Chen
Cancer Biol Ther. 2014 May 1; 15(5): 489–495. Published online 2014 Feb 12. doi: 10.4161/cbt.28016
PMCID:
PMC4026070
ArticlePDF–1.0M
6.
Expression of Several Genes in the Human Chromosome 3p21.3 Homozygous Deletion Region by an Adenovirus Vector Results in Tumor Suppressor Activities in Vitro and in Vivo
Lin Ji, Masahiko Nishizaki, Boning Gao, David Burbee, Masashi Kondo, Craig Kamibayashi, Kai Xu, Nancy Yen, E. Neely Atkinson, Bingliang Fang, Michael I. Lerman, Jack A. Roth, John D. Minna
Cancer Res. Author manuscript; available in PMC 2012 Oct 23.
Published in final edited form as: Cancer Res. 2002 May 1; 62(9): 2715–2720.
PMCID:
PMC3478680
ArticlePDF–1.7M
7.
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases
Kuang Shen, Max L. Valenstein, Xin Gu, David M. Sabatini
J Biol Chem. 2019 Feb 22; 294(8): 2970–2975. Published online 2019 Jan 16. doi: 10.1074/jbc.AC119.007382
PMCID:
PMC6393612
ArticlePDF–1.8M
8.
Seizure features and outcomes in 50 children with GATOR1 variants: A retrospective study, more favorable for epilepsy surgery
Hao Wang, Wenwei Liu, Yuehua Zhang, Qingzhu Liu, Lixin Cai, Yuwu Jiang
Epilepsia Open. 2023 Sep; 8(3): 969–979. Published online 2023 Jul 10. doi: 10.1002/epi4.12770
PMCID:
PMC10472406
ArticlePDF–1.5M
9.
Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism
Shawn B. Egri, Christna Ouch, Hui-Ting Chou, Zhiheng Yu, Kangkang Song, Chen Xu, Kuang Shen
Mol Cell. Author manuscript; available in PMC 2023 May 19.
Published in final edited form as: Mol Cell. 2022 May 19; 82(10): 1836–1849.e5. Published online 2022 Mar 25. doi: 10.1016/j.molcel.2022.03.002
PMCID:
PMC9133170
ArticlePDF–2.9M
10.
The landscape of epilepsy-related GATOR1 variants
Sara Baldassari, Fabienne Picard, Nienke E. Verbeek, Marjan van Kempen, Eva H. Brilstra, Gaetan Lesca, Valerio Conti, Renzo Guerrini, Francesca Bisulli, Laura Licchetta, Tommaso Pippucci, Paolo Tinuper, Edouard Hirsch, Anne de Saint Martin, Jamel Chelly, Gabrielle Rudolf, Mathilde Chipaux, Sarah Ferrand-Sorbets, Georg Dorfmüller, Sanjay Sisodiya, Simona Balestrini, Natasha Schoeler, Laura Hernandez-Hernandez, S. Krithika, Renske Oegema, Eveline Hagebeuk, Boudewijn Gunning, Charles Deckers, Bianca Berghuis, Ilse Wegner, Erik Niks, Floor E. Jansen, Kees Braun, Daniëlle de Jong, Guido Rubboli, Inga Talvik, Valentin Sander, Peter Uldall, Marie-Line Jacquemont, Caroline Nava, Eric Leguern, Sophie Julia, Antonio Gambardella, Giuseppe d’Orsi, Giovanni Crichiutti, Laurence Faivre, Veronique Darmency, Barbora Benova, Pavel Krsek, Arnaud Biraben, Anne-Sophie Lebre, Mélanie Jennesson, Shifteh Sattar, Cécile Marchal, Douglas R Nordli, Jr, Kristin Lindstrom, Pasquale Striano, Lysa Boissé Lomax, Courtney Kiss, Fabrice Bartolomei, Anne Fabienne Lepine, An-Sofie Schoonjans, Katrien Stouffs, Anna Jansen, Eleni Panagiotakaki, Brigitte Ricard-Mousnier, Julien Thevenon, Julitta de Bellescize, Hélène Catenoix, Thomas Dorn, Martin Zenker, Karen Müller-Schlüter, Christian Brandt, Ilona Krey, Tilman Polster, Markus Wolff, Meral Balci, Kevin Rostasy, Guillaume Achaz, Pia Zacher, Thomas Becher, Thomas Cloppenborg, Christopher J. Yuskaitis, Sarah Weckhuysen, Annapurna Poduri, Johannes R. Lemke, Rikke S. Møller, Stéphanie Baulac
Genet Med. 2019; 21(2): 398–408. Published online 2018 Aug 10. doi: 10.1038/s41436-018-0060-2
Correction in:
Genet Med. 2019; 21(7): 1671.
Correction in:
Genet Med. 2019; 21(8): 1896.
PMCID:
PMC6292495
ArticlePDF–1.4M
11.
TUSC4 functions as a tumor suppressor by regulating BRCA1's stability via the E3 ubiquitination pathway
Yang Peng, Hui Dai, Edward Wang, Curtis Chun-Jen Lin, Wei Mo, Guang Peng, Shiaw-Yih Lin
Cancer Res. Author manuscript; available in PMC 2016 Mar 23.
Published in final edited form as: Cancer Res. 2015 Jan 15; 75(2): 378–386. Published online 2014 Dec 5. doi: 10.1158/0008-5472.CAN-14-2315
PMCID:
PMC4804342
ArticlePDF–509K
12.
Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer
Vera N Senchenko, Ekaterina A Anedchenko, Tatiana T Kondratieva, George S Krasnov, Alexei A Dmitriev, Veronika I Zabarovska, Tatiana V Pavlova, Vladimir I Kashuba, Michael I Lerman, Eugene R Zabarovsky
BMC Cancer. 2010; 10: 75. Published online 2010 Mar 1. doi: 10.1186/1471-2407-10-75
PMCID:
PMC2841140
ArticlePDF–977K
13.
Architecture of the human GATOR1 and GATOR1-Rag complexes
Kuang Shen, Rick K. Huang, Edward J. Brignole, Kendall J. Condon, Max L. Valenstein, Lynne Chantranupong, Aimaiti Bomaliyamu, Abigail Choe, Chuan Hong, Zhiheng Yu, David M. Sabatini
Nature. Author manuscript; available in PMC 2018 Oct 5.
Published in final edited form as: Nature. 2018 Apr 5; 556(7699): 64–69. Published online 2018 Mar 28. doi: 10.1038/nature26158
PMCID:
PMC5975964
ArticlePDF–2.4M
14.
Npr2, Yeast Homolog of the Human Tumor Suppressor NPRL2, Is a Target of Grr1 Required for Adaptation to Growth on Diverse Nitrogen Sources
Nathalie Spielewoy, Marisela Guaderrama, James A. Wohlschlegel, Mabelle Ashe, John R. Yates, III, Curt Wittenberg
Eukaryot Cell. 2010 Apr; 9(4): 592–601. doi: 10.1128/EC.00192-09
PMCID:
PMC2863403
ArticlePDF–1.2M
15.
A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex
Taavi K. Neklesa, Ronald W. Davis
PLoS Genet. 2009 Jun; 5(6): e1000515. Published online 2009 Jun 12. doi: 10.1371/journal.pgen.1000515
PMCID:
PMC2686269
ArticlePDF–1.1M
16.
Structure of the nutrient-sensing hub GATOR2
Max L. Valenstein, Kacper B. Rogala, Pranav V. Lalgudi, Edward J. Brignole, Xin Gu, Robert A. Saxton, Lynne Chantranupong, Jonas Kolibius, Jan-Philipp Quast, David M. Sabatini
Nature. Author manuscript; available in PMC 2023 Jan 13.
Published in final edited form as: Nature. 2022 Jul; 607(7919): 610–616. Published online 2022 Jul 13. doi: 10.1038/s41586-022-04939-z
PMCID:
PMC9464592
ArticlePDF–6.9M
17.
The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1
Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini
Cell Rep. Author manuscript; available in PMC 2014 Nov 7.
Published in final edited form as: Cell Rep. 2014 Oct 9; 9(1): 1–8. Published online 2014 Sep 25. doi: 10.1016/j.celrep.2014.09.014
PMCID:
PMC4223866
ArticlePDF–616K
18.
SZT2 Dictates GATOR Control of mTORC1 Signaling
Min Peng, Na Yin, Ming O. Li
Nature. Author manuscript; available in PMC 2017 Aug 24.
Published in final edited form as: Nature. 2017 Mar 16; 543(7645): 433–437. Published online 2017 Feb 15. doi: 10.1038/nature21378
Correction in:
Nature. 2018 May 16
PMCID:
PMC5570594
ArticlePDF–2.1M
19.
A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
Liron Bar-Peled, Lynne Chantranupong, Andrew D. Cherniack, Walter W. Chen, Kathleen A. Ottina, Brian C. Grabiner, Eric D. Spear, Scott L. Carter, Matthew Meyerson, David M. Sabatini
Science. Author manuscript; available in PMC 2013 Jul 31.
Published in final edited form as: Science. 2013 May 31; 340(6136): 1100–1106. doi: 10.1126/science.1232044
PMCID:
PMC3728654
ArticlePDF–2.5M
20.
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
Rachel L. Wolfson, Lynne Chantranupong, Gregory A. Wyant, Xin Gu, Jose M. Orozco, Kuang Shen, Kendall J. Condon, Sabrina Petri, Jibril Kedir, Sonia M. Scaria, Monther Abu-Remaileh, Wayne N. Frankel, David M. Sabatini
Nature. Author manuscript; available in PMC 2017 Aug 15.
Published in final edited form as: Nature. 2017 Mar 16; 543(7645): 438–442. Published online 2017 Feb 15. doi: 10.1038/nature21423
PMCID:
PMC5360989
ArticlePDF–1.9M

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filter your results:

Find related data

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI > Literature > PubMed Central (PMC)
Support Center