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Select item 107898021.

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

Linnea Z. Drexhage, Shengpan Zhang, Maeva Dupont, Franziska Ragaller, Ellen Sjule, Jose Cabezas-Caballero, Lachlan P. Deimel, Helen Robertson, Rebecca A. Russell, Omer Dushek, Erdinc Sezgin, Niloofar Karaji, Quentin J. Sattentau

Nat Commun. 2024; 15: 541. Published online 2024 Jan 15. doi: 10.1038/s41467-023-44619-8

PMCID:: PMC10789802

Article PDF–1.8M

Select item 103293312.

Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo

Ehsan Bahrami, Jan Philipp Schmid, Vindi Jurinovic, Martin Becker, Anna-Katharina Wirth, Romina Ludwig, Sophie Kreissig, Tania Vanessa Duque Angel, Diana Amend, Katharina Hunt, Rupert Öllinger, Roland Rad, Joris Maximilian Frenz, Maria Solovey, Frank Ziemann, Matthias Mann, Binje Vick, Christian Wichmann, Tobias Herold, Ashok Kumar Jayavelu, Irmela Jeremias

Mol Cancer. 2023; 22: 107. Published online 2023 Jul 8. doi: 10.1186/s12943-023-01803-0

PMCID:: PMC10329331

Article PDF–5.5M

Select item 101528683.

ADAM10 Gene Polymorphism and Its Relationship to Hepatocellular Carcinoma in Egyptian HCV Patients Receiving Direct-Acting Antiviral Therapies (DAAs)

Samar Ghanem, Gamalat El Gedawy, Sania Yehia, Hanan Bedair, Samah Awad, Wael Abdel-Razek, Mostafa Elhelbawy, Dalia EL-Sabaawy, Ashraf Yousif Elfert

Asian Pac J Cancer Prev. 2023; 24(1): 149–155. doi: 10.31557/APJCP.2023.24.1.149

PMCID:: PMC10152868

Article PDF–327K

Select item 100982924.

Potential impact of ADAM‐10 genetic variants with the clinical features of oral squamous cell carcinoma

Yi‐Tzu Chen, Chiao‐Wen Lin, Ying‐Erh Chou, Shih‐Chi Su, Lun‐Ching Chang, Chia‐Yi Lee, Ming‐Ju Hsieh, Shun‐Fa Yang

J Cell Mol Med. 2023 Apr; 27(8): 1144–1152. Published online 2023 Mar 22. doi: 10.1111/jcmm.17728

PMCID:: PMC10098292

Article PDF–1.3M

Select item 100939275.

ADAM10 Gene Variants in AD Patients and Their Relationship to CSF Protein Levels

Pablo Agüero-Rabes, Julián Pérez-Pérez, Lucía Cremades-Jimeno, María-Salud García-Ayllón, Adriana Gea-González, María José Sainz, Ignacio Mahillo-Fernández, Raquel Téllez, Blanca Cárdaba, Javier Sáez-Valero, Estrella Gómez-Tortosa

Int J Mol Sci. 2023 Apr; 24(7): 6113. Published online 2023 Mar 24. doi: 10.3390/ijms24076113

PMCID:: PMC10093927

Article PDF–1.3M

Select item 99170056.

Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance

Roberta Zerlotin, Marco Fornaro, Mariella Errede, Patrizia Pignataro, Clelia Suriano, Maddalena Ruggieri, Silvia Colucci, Florenzo Iannone, Maria Grano, Graziana Colaianni

Int J Mol Sci. 2023 Feb; 24(3): 2469. Published online 2023 Jan 27. doi: 10.3390/ijms24032469

PMCID:: PMC9917005

Article PDF–3.8M

Select item 91273287.

The transmembrane domain of the amyloid precursor protein is required for antiamyloidogenic processing by α-secretase ADAM10

Lisa Hitschler, Thorsten Lang

J Biol Chem. 2022 Jun; 298(6): 101911. Published online 2022 Apr 7. doi: 10.1016/j.jbc.2022.101911

PMCID:: PMC9127328

Article PDF–2.7M

Select item 82604698.

Induction of ADAM10 by RT drives fibrosis, resistance, and EMT in pancreatic cancer

Adam C. Mueller, Miles Piper, Andrew Goodspeed, Shiv Bhuvane, Jason S. Williams, Shilpa Bhatia, Andy V. Phan, Benjamin Van Court, Kathryn L. Zolman, Brisa Peña, Ayman J. Oweida, Sara Zakem, Cheryl Meguid, Michael W. Knitz, Laurel Darragh, Thomas E. Bickett, Jacob Gadwa, Luisa Mestroni, Matthew R.G. Taylor, Kimberly R. Jordan, Peter Dempsey, M. Scott Lucia, Martin D. McCarter, Marco Del Chiaro, Wells A. Messersmith, Richard D. Schulick, Karyn A. Goodman, Michael J. Gough, Casey S. Greene, James C. Costello, Antonio Galveo Neto, David Lagares, Kirk C. Hansen, Adrie Van Bokhoven, Sana D. Karam

Cancer Res. Author manuscript; available in PMC 2021 Dec 15.

Published in final edited form as: Cancer Res. 2021 Jun 15; 81(12): 3255–3269. Published online 2021 Feb 1. doi: 10.1158/0008-5472.CAN-20-3892

PMCID:: PMC8260469

Article PDF–3.0M

Select item 79578029.

ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer’s Disease

Izabela Pereira Vatanabe, Rafaela Peron, Marina Mantellatto Grigoli, Silvia Pelucchi, Giulia De Cesare, Thamires Magalhães, Patricia Regina Manzine, Marcio Luiz Figueredo Balthazar, Monica Di Luca, Elena Marcello, Marcia Regina Cominetti

Int J Mol Sci. 2021 Mar; 22(5): 2416. Published online 2021 Feb 28. doi: 10.3390/ijms22052416

PMCID:: PMC7957802

Article PDF–1.4M

Select item 779745910.

ADAM10 promotes the proliferation of ligamentum flavum cells by activating the PI3K/AKT pathway

Bin Pan, Tianqun Huo, Menghan Cao, Li Jing, Xuanxiang Luo, Zhe Qu, Hu Feng, Feng Yuan, Kaijin Guo

Int J Mol Med. 2021 Feb; 47(2): 688–698. Published online 2020 Dec 3. doi: 10.3892/ijmm.2020.4809

PMCID:: PMC7797459

Article PDF–1.2M

Select item 760378011.

α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer’s disease

Pablo Agüero, María José Sainz, María-Salud García-Ayllón, Javier Sáez-Valero, Raquel Téllez, Rosa Guerrero-López, Julián Pérez-Pérez, Adriano Jiménez-Escrig, Estrella Gómez-Tortosa

Alzheimers Res Ther. 2020; 12: 139. Published online 2020 Oct 31. doi: 10.1186/s13195-020-00708-0

PMCID:: PMC7603780

Article PDF–1.1M

Select item 736526012.

ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating S2/S3 cleavage products of Notch

David R. Gibb, Sheinei J. Saleem, Dae-Joong Kang, Mark A. Subler, Daniel H. Conrad

J Immunol. Author manuscript; available in PMC 2020 Jul 16.

Published in final edited form as: J Immunol. 2011 Apr 1; 186(7): 4244–4252. Published online 2011 Mar 2. doi: 10.4049/jimmunol.1003318

PMCID:: PMC7365260

Article PDF–2.8M

Select item 691611013.

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

Larissa Haertle, Tobias Müller, Roy Lardenoije, Anna Maierhofer, Marcus Dittrich, Renzo J. M. Riemens, Samantha Stora, Mathilde Roche, Markus Leber, Steffi Riedel-Heller, Michael Wagner, Martin Scherer, Aimé Ravel, Clotilde Mircher, Cecile Cieuta-Walti, Sophie Durand, Daniel L. A. van de Hove, Per Hoffmann, Alfredo Ramirez, Thomas Haaf, Nady El Hajj, André Mégarbané

Clin Epigenetics. 2019; 11: 195. Published online 2019 Dec 16. doi: 10.1186/s13148-019-0787-x

PMCID:: PMC6916110

Article PDF–1.4M

Select item 675601714.

ADAM10 mediates malignant pleural mesothelioma invasiveness

Christelle Sépult, Marine Bellefroid, Natacha Rocks, Kim Donati, Catherine Gérard, Christine Gilles, Andreas Ludwig, Bernard Duysinx, Agnès Noël, Didier Cataldo

Oncogene. 2019; 38(18): 3521–3534. Published online 2019 Jan 16. doi: 10.1038/s41388-018-0669-2

PMCID:: PMC6756017

Article PDF–2.7M

Select item 649795415.

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

Heledd H. Jarosz-Griffiths, Nicola J. Corbett, Helen A. Rowland, Kate Fisher, Alys C. Jones, Jennifer Baron, Gareth J. Howell, Sally A. Cowley, Satyan Chintawar, M. Zameel Cader, Katherine A. B. Kellett, Nigel M. Hooper

J Biol Chem. 2019 Apr 26; 294(17): 7085–7097. Published online 2019 Mar 14. doi: 10.1074/jbc.RA118.005364

PMCID:: PMC6497954

Article PDF–2.2M

Select item 646035716.

NrCAM is a marker for substrate‐selective activation of ADAM10 in Alzheimer's disease

Tobias Brummer, Stephan A Müller, Francisco Pan‐Montojo, Fumiaki Yoshida, Andreas Fellgiebel, Taisuke Tomita, Kristina Endres, Stefan F Lichtenthaler

EMBO Mol Med. 2019 Apr; 11(4): e9695. Published online 2019 Mar 4. doi: 10.15252/emmm.201809695

PMCID:: PMC6460357

Article PDF–2.8M

Select item 615866917.

Impact of ADAM10 gene polymorphisms on hepatocellular carcinoma development and clinical characteristics

Jr-Shiang Shiu, Ming-Ju Hsieh, Hui-Ling Chiou, Hsiang-Ling Wang, Chao-Bin Yeh, Shun-Fa Yang, Ying-Erh Chou

Int J Med Sci. 2018; 15(12): 1334–1340. Published online 2018 Aug 10. doi: 10.7150/ijms.27059

PMCID:: PMC6158669

Article PDF–385K

Select item 577309418.

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10

Tom C.M. Seegar, Lauren B. Killingsworth, Nayanendu Saha, Peter A. Meyer, Dhabaleswar Patra, Brandon Zimmerman, Peter W. Janes, Eric Rubinstein, Dimitar B. Nikolov, Georgios Skiniotis, Andrew C. Kruse, Stephen C. Blacklow

Cell. Author manuscript; available in PMC 2018 Dec 14.

Published in final edited form as: Cell. 2017 Dec 14; 171(7): 1638–1648.e7. Published online 2017 Dec 7. doi: 10.1016/j.cell.2017.11.014

PMCID:: PMC5773094

Article PDF–1.0M

Select item 563258919.

Role of ADAM10 in Intestinal Crypt Homeostasis and Tumorigenesis

Peter J. Dempsey

Biochim Biophys Acta. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: Biochim Biophys Acta. 2017 Nov; 1864(11 Pt B): 2228–2239. Published online 2017 Jul 22. doi: 10.1016/j.bbamcr.2017.07.011

PMCID:: PMC5632589

Article PDF–951K

Select item 547302220.

Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins

Alexandra L. Matthews, Justyna Szyroka, Richard Collier, Peter J. Noy, Michael G. Tomlinson

Biochem Soc Trans. 2017 Jun 15; 45(3): 719–730. Published online 2017 Jun 15. doi: 10.1042/BST20160290

PMCID:: PMC5473022

Article PDF–756K

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