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Select item 101878821.

N-acetyltransferase 2 genetic polymorphism modifies genotoxic and oxidative damage from new psychoactive substances

Raúl A. Salazar-González, Mark A. Doll, David W Hein

Arch Toxicol. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Arch Toxicol. 2023 Jan; 97(1): 189–199. Published online 2022 Sep 23. doi: 10.1007/s00204-022-03383-2

PMCID:: PMC10187882

Article PDF–956K

Select item 100790692.

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

Jorge E. Gutiérrez-Virgen, Maricela Piña-Pozas, Esther A. Hernández-Tobías, Lucia Taja-Chayeb, Ma. de Lourdes López-González, Marco A. Meraz-Ríos, Rocío Gómez

PLoS One. 2023; 18(4): e0283726. Published online 2023 Apr 6. doi: 10.1371/journal.pone.0283726

PMCID:: PMC10079069

Article PDF–2.5M

Select item 98843973.

Pharmacogenetic testing for NAT2 genotypes in a Tanzanian population across the lifespan to guide future personalized isoniazid dosing

Maano V. Masiphephethu, Margaretha Sariko, Thomas Walongo, Athanasia Maro, Dorcus Mduma, Jean Gratz, Mohammad Alshaer, Charles A. Peloquin, Estomih Mduma, Stellah G. Mpagama, Tania Thomas, Eric R. Houpt, Afsatou Traore, Pascal Bessong, Scott K. Heysell, Darwin J. Operario

Tuberculosis (Edinb) Author manuscript; available in PMC 2023 Jan 29.

Published in final edited form as: Tuberculosis (Edinb). 2022 Sep; 136: 102246. Published online 2022 Aug 8. doi: 10.1016/j.tube.2022.102246

PMCID:: PMC9884397

Article PDF–864K

Select item 97029984.

Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines

Kyung U Hong, Raúl A Salazar-González, Kennedy M Walls, David W Hein

Toxicol Sci. 2022 Dec; 190(2): 158–172. Published online 2022 Sep 26. doi: 10.1093/toxsci/kfac103

PMCID:: PMC9702998

Article PDF–922K

Select item 95224185.

Influence of NAT2 Genotype and Maturation on Isoniazid Exposure in Low-Birth-Weight and Preterm Infants With or Without Human Immunodeficiency Virus (HIV) Exposure

Agathe Béranger, Adrie Bekker, Belén P Solans, Mark F Cotton, Mark Mirochnick, Avy Violari, Jiajia Wang, Mae Cababasay, Lubbe Wiesner, Renee Browning, Jack Moye, Edmund V Capparelli, Radojka M Savic

Clin Infect Dis. 2022 Sep 15; 75(6): 1037–1045. Published online 2022 Feb 4. doi: 10.1093/cid/ciac001

PMCID:: PMC9522418

Article PDF–8.5M

Select item 91120766.

Expression of Arylamine N-Acetyltransferase 2 Activity in Immortalized Human Bronchial Epithelial Cells

James T.F. Wise, Raúl A. Salazar-González, Mariam R. Habil, Mark A. Doll, David W. Hein

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2022 May 1; 442: 115993. Published online 2022 Mar 27. doi: 10.1016/j.taap.2022.115993

PMCID:: PMC9112076

Article PDF–1.3M

Select item 80463157.

Evaluation of Genetic Polymorphisms of N-acetyltransferase 2 and Relation with Chronic Myeloid Leukemia

Entesar M Tebien, Hiba B Khalil, Jeremy Mills, Abozer Y. Elderdery

Asian Pac J Cancer Prev. 2020 Dec; 21(12): 3711–3717. doi: 10.31557/APJCP.2020.21.12.3711

PMCID:: PMC8046315

Article PDF–397K

Select item 74970188.

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N‐Acetyltransferase NAT2

Dr. Louis P. Conway, Dr. Veronica Rendo, M. Sc. Mário S. P. Correia, Prof. Dr. Ingvar A. Bergdahl, Prof. Dr. Tobias Sjöblom, Prof. Dr. Daniel Globisch

Angew Chem Int Ed Engl. 2020 Aug 17; 59(34): 14342–14346. Published online 2020 Jul 8. doi: 10.1002/anie.202005915

PMCID:: PMC7497018

Article PDF–2.0M

Select item 70600959.

N-acetyltransferase 2 acetylator genotype-dependent N-acetylation of 4-aminobiphenyl in cryopreserved human hepatocytes

Mariam R. Habil, Mark A. Doll, David W. Hein

Pharmacogenet Genomics. Author manuscript; available in PMC 2021 Apr 1.

Published in final edited form as: Pharmacogenet Genomics. 2020 Apr; 30(3): 61–65. doi: 10.1097/FPC.0000000000000394

PMCID:: PMC7060095

Article PDF–219K

Select item 704678810.

The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis

Jeong Yee, So Min Kim, Ji Min Han, Nari Lee, Ha Young Yoon, Hye Sun Gwak

Sci Rep. 2020; 10: 3658. Published online 2020 Feb 27. doi: 10.1038/s41598-020-60467-8

PMCID:: PMC7046788

Article PDF–2.4M

Select item 701739211.

Role of Human N-Acetyltransferase 2 Genetic Polymorphism on Aromatic Amine Carcinogen-induced DNA Damage and Mutagenicity in a Chinese Hamster Ovary Cell Mutation Assay

Kristin J. Baldauf, Raúl A. Salazar-González, Mark A. Doll, William M. Pierce, Jr., J. Christopher States, David W. Hein

Environ Mol Mutagen. Author manuscript; available in PMC 2021 Feb 1.

Published in final edited form as: Environ Mol Mutagen. 2020 Feb; 61(2): 235–245. Published online 2019 Sep 30. doi: 10.1002/em.22331

PMCID:: PMC7017392

Article PDF–604K

Select item 693428912.

NAT2 gene polymorphisms and endometriosis risk: A PRISMA-compliant meta-analysis

Zhangming Wei, Mengmeng Zhang, Xinyue Zhang, Mingyu Yi, Xiaomeng Xia, Xiaoling Fang

PLoS One. 2019; 14(12): e0227043. Published online 2019 Dec 27. doi: 10.1371/journal.pone.0227043

PMCID:: PMC6934289

Article PDF–1.3M

Select item 681682213.

N‐acetyl transferase 2/environmental factors and their association as a modulating risk factor for sporadic colon and rectal cancer

Lucia M. Procopciuc, Gelu Osian, Mihaela Iancu

J Clin Lab Anal. 2017 Sep; 31(5): e22098. Published online 2016 Nov 24. doi: 10.1002/jcla.22098

PMCID:: PMC6816822

Article PDF–328K

Select item 676104614.

Doneness Preferences, Meat and Meat-derived Heterocyclic Amines Intake, and NAT2 Polymorphisms: Association with Colorectal Adenoma in Japanese Brazilians

Sanjeev Budhathoki, Motoki Iwasaki, Taiki Yamaji, Gerson Shigeaki Hamada, Nelson Tomio Miyajima, Jose Carlos Zampieri, Sangita Sharma, Mohammadreza Pakseresht, Fariba Kolahdooz, Junko Ishihara, Ribeka Takachi, Hadrien Charvat, Loïic Le Marchand, Shoichiro Tsugane

Eur J Cancer Prev. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: Eur J Cancer Prev. 2020 Jan; 29(1): 7–14. doi: 10.1097/CEJ.0000000000000506

PMCID:: PMC6761046

Article PDF–345K

Select item 670906715.

Association between NAT2 polymorphisms and acute leukemia risk: A meta-analysis

Xiaoxiao Zhu, Yanbing Liu, Guangwu Chen, Qiang Guo, Zhen Zhang, Lin Zhao, Ran Wei, Xunqiang Yin, Yunhong Zhang, Bin Wang, Xia Li

Medicine (Baltimore) 2019 Mar; 98(12): e14942. Published online 2019 Mar 22. doi: 10.1097/MD.0000000000014942

PMCID:: PMC6709067

Article PDF–829K

Select item 665874016.

Genomewide Association Study Confirming the Association of NAT2 with Susceptibility to Antituberculosis Drug-Induced Liver Injury in Thai Patients

Supharat Suvichapanich, Sukanya Wattanapokayakit, Taisei Mushiroda, Hideki Yanai, Charoen Chuchottawon, Tassawan Kantima, Supalert Nedsuwan, Wimon Suwankesawong, Cholticha Sonsupap, Roongkarn Pannarunothai, Sukanya Tumpattanakul, Warawut Bamrungram, Achara Chaiwong, Surakameth Mahasirimongkol, Sasithorn Mameechai, Weerapat Panthong, Nantawan Klungtes, Amara Munsoo, Udomrat Chauychana, Molrudee Maneerat, Koya Fukunaga, Yosuke Omae, Katsushi Tokunaga

Antimicrob Agents Chemother. 2019 Aug; 63(8): e02692-18. Prepublished online 2019 May 20. Published online 2019 Jul 25. doi: 10.1128/AAC.02692-18

PMCID:: PMC6658740

Article PDF–1.4M

Select item 656292317.

Effects of genetic variability on rifampicin and isoniazid pharmacokinetics in South African patients with recurrent tuberculosis

Anushka Naidoo, Maxwell Chirehwa, Veron Ramsuran, Helen McIlleron, Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Ravesh Singh, Sinaye Ncgapu, John Adamson, Katya Govender, Paolo Denti, Nesri Padayatchi

Pharmacogenomics. 2019 Mar; 20(4): 225–240. Published online 2019 Feb 15. doi: 10.2217/pgs-2018-0166

PMCID:: PMC6562923

Article PDF–2.2M

Select item 654270818.

N-ACETYLTRANSFERASE 2 ENZYME GENOTYPE-PHENOTYPE DISCORDANCES IN BOTH HIV-NEGATIVE AND HIV-POSITIVE NIGERIANS

Olayinka A. Kotila, Olufunmilayo I. Fawole, Olufunmilayo I. Olopade, Adejumoke I. Ayede, Adeyinka G. Falusi, Chinedum P. Babalola

Pharmacogenet Genomics. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Pharmacogenet Genomics. 2019 Jul; 29(5): 106–113. doi: 10.1097/FPC.0000000000000373

PMCID:: PMC6542708

Article PDF–802K

Select item 649354819.

Genetic Polymorphism of NAT2 Metabolizing Enzymes on Phenytoin Pharmacokinetics in Indian Epileptic Patients Developing Toxicity

M. Murali, T. Manjari, B. Madhuri, S. Raghavan, D.C. Jain, S. Vivekanandhan

CNS Neurosci Ther. 2012 Apr; 18(4): 350–358. Published online 2012 Jan 24. doi: 10.1111/j.1755-5949.2011.00291.x

PMCID:: PMC6493548

Article PDF–867K

Select item 642194420.

NAT2 variants and toxicity related to anti-tuberculosis agents: a systematic review and meta-analysis

M. Richardson, J. Kirkham, K. Dwan, D. J. Sloan, G. Davies, A. L. Jorgensen

Int J Tuberc Lung Dis. 2019 Mar; 23(3): 293–316. doi: 10.5588/ijtld.18.0324

PMCID:: PMC6421944

Article PDF–3.8M

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