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3H-CGP 12177 Whole Cell Binding Assay from Article 10.1038/sj.bjp.0706048: "The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors."
Assay data:25 Active, 7 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]DHA from beta2 adrenergic receptor (unknown origin) stably expressed in HEK293 cell membranes measured after 90 mins by scintillation counting analysis
Assay data:18 Active, 8 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
BK Channel Variant Modulator Selectivity Assay
Assay data:286 Active, 904 Activity ≤ 1 nM, 951 Activity ≤ 1 µM, 951 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177)
Assay data:24 Active, 6 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol)
Assay data:27 Active, 3 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 871 Tested
DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin)
Assay data:72 Active, 3 Activity ≤ 1 nM, 59 Activity ≤ 1 µM, 871 Tested
Displacement of [3H]CGP12177 from beta-1 adrenergic receptor in Wistar rat cerebral cortex membrane by liquid scintillation counting
Assay data:8 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Displacement of [3H]CGP12177 from beta-1 adrenergic receptor in rat cerebral cortex by liquid scintillation method
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
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