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Agonist activity at human PPARG in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:4 Active, 5 Activity ≤ 1 µM, 238 Tested
SummaryRelated BioAssays by Target
Binding affinity to PPARgamma (unknown origin) assessed as inhibition constant by Lanthascreen TR-FRET assay relative to control
Assay data:4 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of adiponectin synthesis in human differentiated BMMSC cells measured after 5 days in the presence of IDX induction medium by ELISA
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as disruption of FOXM1-DNA complex preincubated for 1.5 hrs followed by DNA addition measured after 20 mins by EMSA
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Induction of adipogenesis in human AT-MSC assessed as adiponectin secretion in IDX medium incubated for 5 days by ELISA
Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested
Binding affinity to human recombinant PPARgamma by Cheng-Prusoff equation based competitive binding TR-FRET assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Agonist activity at PPARgamma (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Drug concentration at steady state in human at 200 to 600 mg, po QD after 24 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Induction of mitochondrial dysfunction in Sprague-Dawley rat liver mitochondria assessed as inhibition of mitochondrial respiration per mg mitochondrial protein measured for 20 mins by A65N-1 oxygen probe based fluorescence assay
Assay data:13 Active, 28 Activity ≤ 1 µM, 72 Tested
Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-FRET competitive binding assay
Assay data:7 Active, 3 Activity ≤ 1 µM, 13 Tested
Displacement of fluormone Pan-PPAR Green from human GST-tagged PPARgamma-LBD by TR-FRET assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds
Assay data:1106 Active, 14 Activity ≤ 1 nM, 6478 Activity ≤ 1 µM, 7578 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
qHTS assay to identify small molecule antagonists of the sonic hedgehog signaling (Shh) pathway
Assay data:1356 Active, 2 Activity ≤ 1 nM, 487 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in guinea pig ventricular myocytes
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Agonist activity at PPARgamma (unknown origin)
High-throughput drug toxicity screening in the BPDCN cell line Cal-1
Assay data:23 Activity ≤ 1 nM, 235 Activity ≤ 1 µM, 1910 Tested
SummaryCompounds, activity ≤ 1 µM
Unbound Cmax in human plasma
Assay data:66 Active, 5 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 85 Tested
Agonist activity at PPARgamma (unknown origin) by nuclear receptor cofactor assay
qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary
Assay data:277 Active, 1 Activity ≤ 1 nM, 62 Activity ≤ 1 µM, 10486 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation
Assay data:74 Activity ≤ 1 nM, 704 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
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