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Agonist activity at GPR40 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
96-Well Adherent Reporter Cell Assay from Article 10.1016/j.bmcl.2006.12.084: "Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor."
Assay data:21 Active, 10 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay
Assay data:17 Active, 7 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested
Agonist activity at human FFA1 expressed in HEK293 cells assessed as stimulation of intracellular calcium mobilization measured at 2 secs time interval for 90 secs by Calcium-3 dye based FLIPR assay
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Agonist activity at human GPR40 expressed in HEK293 cells assessed as increase in calcium flux measured every 2 secs for 90 secs by Calcium-3 dye based FLIPR assay
Agonist activity at human GPR40 expressed in CHO cells after 24 hrs by NFAT-luciferase reporter gene assay
Assay data:12 Active, 15 Activity ≤ 1 µM, 23 Tested
Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approved drugs and bioactive compounds
Assay data:1106 Active, 14 Activity ≤ 1 nM, 6478 Activity ≤ 1 µM, 7578 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Agonist activity at human C-terminal eYFP-tagged FFA1 receptor expressed in HEK-293 cells assessed as beta-arrestin2 recruitment incubated for 5 mins by BRET assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
Displacement of 3-(2-Fluoro-4-((2'-methyl-4'-(2-(2-((7-nitrobenzo[c][1,2,5]-oxadiazol-4-yl)amino)ethoxy)ethoxy)-[1,1'-biphenyl]-3-yl)-methoxy)phenyl)propanoic acid from N-terminal NLUC-tagged FFA1 receptor (unknown origin) expressed in human Flp-In T-REX-293 cell membrane coexpressing mGluR5 incubated for 1 hr by equilibrium BRET assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
High-throughput drug toxicity screening in the BPDCN cell line Gen2.2
Assay data:29 Activity ≤ 1 nM, 425 Activity ≤ 1 µM, 1910 Tested
SummaryCompounds, activity ≤ 1 µM
Agonist activity at FFAR1 (unknown origin) assessed as increase in ERK1/2 MAP kinase phosphorylation
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Agonist activity at rat GPR40 expressed in CHO cells by calcium flux assay
Assay data:22 Active, 18 Activity ≤ 1 µM, 23 Tested
Agonist activity at human GPR40 expressed in CHO cells by calcium flux assay
Assay data:23 Active, 22 Activity ≤ 1 µM, 23 Tested
Cell Proliferation Assay Versus the ED40515 IL2 Dependent ATL cell lines
Assay data:144 Active, 1 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 464 Tested
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation
Assay data:57 Activity ≤ 1 nM, 344 Activity ≤ 1 µM, 2023 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2)
Assay data:53 Activity ≤ 1 nM, 332 Activity ≤ 1 µM, 2023 Tested
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation
Assay data:74 Activity ≤ 1 nM, 704 Activity ≤ 1 µM, 2023 Tested
qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation
Assay data:59 Activity ≤ 1 nM, 281 Activity ≤ 1 µM, 2023 Tested
Agonist activity at FFAR1 expressed in HEK 293 cells assessed as beta-arrestin recruitment after 30 mins by BRET assay
Assay data:37 Active, 28 Activity ≤ 1 µM, 38 Tested
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