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Compound was evaluated for inhibition of human MAOA in an in vitro cell free assay measured by fluorescence spectroscopy
Assay data:28 Active, 4 Activity ≤ 1 µM, 1218 Tested
SummaryRelated BioAssays by Target
Agonist activity at human PPARG in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:4 Active, 5 Activity ≤ 1 µM, 238 Tested
Antagonist activity at human ADRA2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:80 Active, 18 Activity ≤ 1 µM, 1172 Tested
Compound was evaluated for inhibition of human ABCB11 in an in vitro assay with cellular components measured by filtration, liquid scintillation counting
Assay data:43 Active, 3 Activity ≤ 1 µM, 508 Tested
Binding affinity to PPARgamma (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at GAL4-fused human PPARgamma expressed in HepG2 cells
Agonist activity at human PPARgamma transfected in HEK293 cells assessed increase in luciferase activity incubated for 24 hrs
Displacement of [3H]rosiglitazone from human PPAR-gamma incubated for 1 day by radioligand binding assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 7 Tested
Agonist activity at PPAR-gamma in human BMMSC cells assessed as induction of adiponectin production in presence of IDX adipogenic induction medium and measured on day 5 by ELISA
Assay data:4 Active, 2 Activity ≤ 1 µM, 8 Tested
Cmax in rat at 3 mg/kg, iv
Assay data:1 Active, 1 Tested
Summary
Inhibition of recombinant human MAO-B
Assay data:19 Active, 8 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TNFalpha stimulated PPARgamma phosphorylation at Ser273 residue in mouse 3T3-L1 cells at 5 uM preincubated for 60 mins followed by TNFalpha addition for 90 mins by Western blot analysis
Agonist activity at yeast Gal4-fused human PPARgamma transfected in human HepG2 cells assessed as transactivation by measuring beta-galactosidase activity incubated for 20 hrs by luminometry
Assay data:10 Active, 1 Activity ≤ 1 µM, 26 Tested
Agonist activity at human PPARgamma expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 14 Tested
Agonist activity at pBIND tagged human PPARgamma expressed in human HEK293 cells incubated for 18 hrs by dual luciferase reporter assay relative to control
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Agonist activity at human PPARgamma measured by dual luciferase reporter gene assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 13 Tested
Antiviral activity against HBV infected HepG2 2.2.15 cells assessed as reduction in HBsAg level at 50 microg/ml for 48 hrs by ELISA
Assay data:1 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Partial agonist activity at PPARgamma LBD (unknown origin) assessed as increase in FITC-labeled PGC-1alpha coactivator peptide recruitment by HTRF assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Stabilization of PPARgamma LBD (unknown origin)/FITC-labeled PGC-1alpha (unknown origin) protein-protein interaction assessed as dissociation constant by fluorescence anisotropy assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to PPARgamma LBD (unknown origin) assessed as dissociation constant followed by heating for 3 mins by Bradford assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
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