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Antiproliferative activity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antitumor activity against mouse H22 cells transplanted in Kunming mouse assessed as tumor growth inhibition at 100 mg/kg/day, po administered 5 days per week for 2 weeks
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antitumor activity against human HCT116 cells xenografted in nude BALB/c mouse assessed as reduction in tumor weight at 540 mg/kg, po administered once daily for 4 weeks measured every 3 days during compound dosing
Human thymidylate synthetase (Nucleoside synthesis and metabolism)
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway
Assay data:1034 Active, 2 Activity ≤ 1 nM, 491 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Cytotoxicity against human RKOp27 cells after 3 days by MTT assay
Assay data:24 Active, 23 Activity ≤ 1 µM, 24 Tested
Cytotoxicity against human RKOp27 cells by MTT assay
Assay data:11 Active, 10 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
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