BioAssays, Active for PubChem Compound (Select 5591) - PubChem BioAssay - NCBI

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Select item 19618551.

Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Assay data:49 Active, 5 Activity ≤ 1 µM, 1243 Tested

AID:: 1961855

Summary Related BioAssays by Target

Select item 19618392.

Binding affinity towards human SLC6A3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent dopamine transporter

Assay data:128 Active, 38 Activity ≤ 1 µM, 927 Tested

AID:: 1961839

Summary Related BioAssays by Target

Select item 19618383.

Binding affinity towards human SLC6A2 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent noradrenaline transporter

Assay data:137 Active, 27 Activity ≤ 1 µM, 927 Tested

AID:: 1961838

Summary Related BioAssays by Target

Select item 19618274.

Compound was evaluated for inhibition of human PTGS2 in an in vitro cell free assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 2

Assay data:79 Active, 12 Activity ≤ 1 µM, 1183 Tested

AID:: 1961827

Summary Related BioAssays by Target

Select item 19618265.

Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 1

Assay data:96 Active, 35 Activity ≤ 1 µM, 927 Tested

AID:: 1961826

Summary Related BioAssays by Target

Select item 19618236.

Agonist activity at human PPARG in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Peroxisome proliferator-activated receptor gamma

Assay data:4 Active, 5 Activity ≤ 1 µM, 238 Tested

AID:: 1961823

Summary Related BioAssays by Target

Select item 19618207.

Binding affinity towards human PGR in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Progesterone receptor

Assay data:87 Active, 51 Activity ≤ 1 µM, 927 Tested

AID:: 1961820

Summary Related BioAssays by Target

Select item 19618158.

Compound was evaluated for inhibition of human PDE4D in an in vitro cell free assay measured by scintillation proximity assay

Source:: ChEMBL

Protein Target:: cAMP-specific 3',5'-cyclic phosphodiesterase 4D

Assay data:109 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 1242 Tested

AID:: 1961815

Summary Related BioAssays by Target

Select item 19618149.

Compound was evaluated for inhibition of human PDE4A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Assay data:46 Active, 10 Activity ≤ 1 µM, 927 Tested

AID:: 1961814

Summary Related BioAssays by Target

Select item 196180710.

Binding affinity towards human NR3C1 in an in vitro cell free assay measured by filtration, radioactivity method

Source:: ChEMBL

Protein Target:: Glucocorticoid receptor

Assay data:83 Active, 2 Activity ≤ 1 nM, 58 Activity ≤ 1 µM, 1095 Tested

AID:: 1961807

Summary Related BioAssays by Target

Select item 196180411.

Antagonist activity at human NR13 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Nuclear receptor subfamily 1 group I member 3

Assay data:13 Active, 3 Activity ≤ 1 µM, 36 Tested

AID:: 1961804

Summary Related BioAssays by Target

Select item 196179912.

Antagonist activity at human NR1H4 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Bile acid receptor

Assay data:3 Active, 36 Tested

AID:: 1961799

Summary Related BioAssays by Target

Select item 196177813.

Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2B

Assay data:147 Active, 45 Activity ≤ 1 µM, 1167 Tested

AID:: 1961778

Summary Related BioAssays by Target

Select item 196177414.

Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:116 Active, 1 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 1135 Tested

AID:: 1961774

Summary Related BioAssays by Target

Select item 196177115.

Antagonist activity at human HTR1A in an in vitro cell-based assay measured by fluorescent imaging plate reader

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:58 Active, 20 Activity ≤ 1 µM, 876 Tested

AID:: 1961771

Summary Related BioAssays by Target

Select item 196175416.

Antagonist activity at human GABRA1 in an in vitro cell-based assay measured by fluorescent imaging plate reader

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 4

Assay data:2 Active, 297 Tested

AID:: 1961754

Summary Related BioAssays by Target

Select item 196173917.

Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: D(3) dopamine receptor

Assay data:142 Active, 80 Activity ≤ 1 µM, 896 Tested

AID:: 1961739

Summary Related BioAssays by Target

Select item 196173618.

Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting

Source:: ChEMBL

Protein Target:: D(1A) dopamine receptor

Assay data:117 Active, 49 Activity ≤ 1 µM, 927 Tested

AID:: 1961736

Summary Related BioAssays by Target

Select item 196171819.

Antagonist activity human CHRM1 in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Muscarinic acetylcholine receptor M1

Assay data:120 Active, 64 Activity ≤ 1 µM, 812 Tested

AID:: 1961718

Summary Related BioAssays by Target

Select item 196170620.

Binding affinity towards human AR in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Androgen receptor

Assay data:69 Active, 48 Activity ≤ 1 µM, 927 Tested

AID:: 1961706

Summary Related BioAssays by Target

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Proteins (40)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (180)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (43)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (120)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (147)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (6)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (40)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (122)
BioAssays extracted from the literature
NIH MLP (11)
BioAssays deposited by the NIH Molecular Libraries Program
Other (69)
BioAssays deposited by other experimentalists

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