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Inhibition of OATP1B1 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of UGT1A1 (unknown origin)
Solubility of compound at pH 7.4
Assay data:2 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Solubility of compound at pH 2
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as substrate incubated for 60 mins followed by substrate addition and measured after 60 mins
Assay data:40 Active, 30 Activity ≤ 1 µM, 46 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antiproliferative activity against MATP-null human HCT-116 cells isogenic cell model assessed as maximal cell growth inhibition at 20 uM incubated for 96 hrs by Cell Titer-Glo assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 13 Tested
Inhibition of recombinant His6-tagged MAT2A (unknown origin) expressed in SF9 insect cells using L-Met as substrate preincubated for 60 mins followed by substrate and ATP addition and measured after 60 mins by spectrophotometric analysis
Assay data:246 Active, 246 Activity ≤ 1 µM, 246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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