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Binding affinity towards human ADORA3 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:82 Active, 4 Activity ≤ 1 µM, 1215 Tested
SummaryRelated BioAssays by Target
Inhibition of NEK11 (unknown origin) assessed as dissociation constant
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of NEK9 (unknown origin) assessed as dissociation constant
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Inhibition of NEK7 (unknown origin) assessed as dissociation constant
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of NEK6 (unknown origin) assessed as dissociation constant
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of NEK5 (unknown origin) assessed as dissociation constant
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibition of NEK4 (unknown origin) assessed as dissociation constant
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of NEK3 (unknown origin) assessed as dissociation constant
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of NEK2 (unknown origin) assessed as dissociation constant
Assay data:8 Active, 5 Activity ≤ 1 µM, 8 Tested
Inhibition of NEK1 (unknown origin) assessed as dissociation constant
Assay data:6 Active, 2 Activity ≤ 1 µM, 6 Tested
Competitive inhibition of SYK (unknown origin) assessed as inhibition constant in the presence of ATP at Km concentration
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US9212178: "Substituted pyrimidine compounds and their use as SYK inhibitors"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Competition Binding Assays from Article 10.1021/acschembio.5b01063: "Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors."
Assay data:26 Active, 2 Activity ≤ 1 µM, 29 Tested
Aurora B Kinase Inhibition Assay from US Patent US9145414: "1,2,4-triazine-6-carboxamide derivative"
Assay data:9 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell Lung cell line, single concentration
Assay data:3242 Active, 74206 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
NCI human tumor cell line growth inhibition assay. Data for the A498 Non-Small Cell Lung cell line, single concentration
Assay data:3589 Active, 71200 Tested
NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Non-Small Cell Lung cell line, single concentration
Assay data:4429 Active, 72551 Tested
NCI human tumor cell line growth inhibition assay. Data for the CAKI-1 Non-Small Cell Lung cell line, single concentration
Assay data:2950 Active, 69617 Tested
NCI human tumor cell line growth inhibition assay. Data for the ACHN Non-Small Cell Lung cell line, single concentration
Assay data:3328 Active, 75995 Tested
NCI human tumor cell line growth inhibition assay. Data for the UO-31 Non-Small Cell Lung cell line, single concentration
Assay data:3630 Active, 76159 Tested
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