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Binding affinity to A2aR (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Summary
Antagonist activity at adenosine A2A receptor (unknown origin)
Assay data:15 Active, 2 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Antagonist activity at human A2aR expressed in HEK293 cells assessed as reduction in NECA-induced cAMP production incubated for 20 mins in presence of 1 uM NECA by ultra LANCE cAMP detection assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antagonist activity at human A2aR expressed in HEK293 cells assessed as reduction in NECA-induced cAMP production incubated for 20 mins in presence of 40 nM NECA by ultra LANCE cAMP detection assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at human A2aR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 60 mins by ultra LANCE cAMP detection assay
Assay data:45 Active, 37 Activity ≤ 1 µM, 58 Tested
Antagonist activity at adenosine 2A receptor (unknown origin) in presence of high adenosine
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at adenosine 2A receptor in human T cells assessed as inhibition of cAMP incubated for 10 mins by Eu-cAMP tracer based TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human adenosine 2A receptor expressed in HEK293 cells assessed as inhibition of NECA-induced cAMP by immunoassay
Displacement of [3H]-ZM241385 from human adenosine 2B receptor expressed in HEK-293 cells incubated for 60 mins by scintillation counting method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO-K1 cells incubated for 90 mins by scintillation counting method
Displacement of [3H]CGS-21680 from human adenosine 2A receptor expressed in HEK293 cells incubated for 90 mins by scintillation counting method
Displacement of [125I]-AB MECA from human adenosine A3 receptor expressed in CHO-K1 cells incubated for 60 mins by scintillation counting method
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay
Assay data:1477 Active, 244 Activity ≤ 1 µM, 58936 Tested
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:368 Active, 78 Activity ≤ 1 µM, 5114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Assay data:158 Active, 29 Activity ≤ 1 µM, 5114 Tested
qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary
Assay data:378 Active, 203 Activity ≤ 1 µM, 2480 Tested
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