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Disruption of beta-fibrillation of IAPP (unknown origin) assessed as half life of protein
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of islet amyloid polypeptide (unknown origin) aggregation
Assay data:1 Active, 1 Tested
Inhibition of islet amyloid polypeptide (unknown origin) aggregation after 24 hrs by thioflavin T based fluorescence assay
Assay data:17 Active, 4 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human IAPP fibril formation assessed as decrease in final fluorescence intensity at compound/protein ratio of 10/1 by ThT fluorescence assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human IAPP fibril formation assessed as increase of aggregation half life at compound/protein ratio of 10/1 by ThT fluorescence assay
Binding affinity to human IAPP fibril at 2 mM by saturation transfer difference NMR analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human IAPP fibril formation at 50 uM at 25 degC measured after 6 hrs by ThT fluorescence assay
Inhibition of human IAPP fibril formation at 50 uM at 25 degC measured after 6 hrs by atomic force microscopy
Inhibition of thioflavin T binding to human amylin assessed as half life
Inhibition of IAPP assembly at 1:1 protein to compound ratio after 1 to 5 days by circular dichroism spectra analysis
Inhibition of IAPP assembly assessed as prenucleation period at 1:1 protein to compound ratio by NMR analysis
Inhibition of IAPP assembly at 1:1 protein to compound ratio after 29 days by NMR analysis
Inhibition of IAPP assembly assessed as nucleation period at 1:1 protein to compound ratio (Rvb = 15.3 days)
Inhibition of IAPP fibrillation at 1:1 protein to compound ratio after 44 days by transmission electron microscopy
Activity of IAPP assessed as maximal rate of self-assembly at 1:1 protein to compound ratio by NMR analysis (Rvb = 12.2/day)
Inhibition of IAPP assembly at 1:1 protein to compound ratio after 18 to 31 days by NMR analysis
Inhibition of IAPP fibril formation at 1:10 protein to compound ratio after 24 hrs by transmission electron microscopy analysis
Inhibition of IAPP fibril formation at 1:10 protein to compound ratio after 3 hrs by transmission electron microscopy analysis
Inhibition of IAPP fibril formation assessed as inhibition of aggregate formation at 1:10 protein to compound ratio by thioflavin T fluorescence assay relative to untreated control
Assay data:3 Tested
Inhibition of IAPP fibril formation assessed as fold increase in lag time for aggregate formation at 1:10 protein to compound ratio by thioflavin T fluorescence assay relative to untreated control
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