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Inhibition Assay from US Patent US8710232: "Imidazole derivatives used as TAFIa inhibitors"
Assay data:16 Active, 13 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of carboxypeptidase B in porcine pancreas using hippuryl-L-Arg as substrate preincubated with substrate for 2 mins followed by enzyme addition and measured after 5 mins by colorimetric method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human pancreatic CPB incubated for 25 mins using hippuryl-arginine as substrate by spectrophotometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human CPB1 at 1 nM to 1 mM using AAFA as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotometry
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human CPB1 using AAFA as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotometry
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of porcine pancreas carboxypeptidase B after 10 mins in absence of DTT
Inhibition of porcine pancreas carboxypeptidase B after 10 mins in presence of DTT
Human Carboxypeptidase B1 (tissue) (M14: Carboxypeptidase A)
Assay data:2 Active, 2 Tested
Inhibition of CBP (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis
Assay data:7 Active, 3 Activity ≤ 1 µM, 14 Tested
Inhibition of pig pancreatic carboxypeptidase B using Hip-Arg as substrate incubated for 10 mins prior to substrate addition measured after 30 mins by spectrophotometric analysis in presence of dithiothreitol
Assay data:8 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 9 Tested
Inhibition of human pancreatic carboxypeptidase B
Assay data:10 Active, 8 Activity ≤ 1 µM, 12 Tested
Inhibition of human recombinant carboxypeptidase B expressed in Pichia pastoris system
Assay data:8 Active, 27 Tested
Inhibition of human recombinant carboxypeptidase B expressed in Saccharomyces cerevisiae by microtiter plate method
Assay data:6 Tested
Inhibition of human carboxypeptidase B
Assay data:7 Active, 11 Tested
Inhibition of carboxypeptidase B
Inhibition of porcine pancreatic carboxypeptidase B
Assay data:10 Active, 7 Activity ≤ 1 µM, 13 Tested
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