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Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced IkappaBalpha protein expression level at 10 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced JNK phosphorylation level at 10 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced p-38 phosphorylation level at 10 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced ERK phosphorylation level at 10 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced IkappaBalpha phosphorylation level at 10 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human HEK-Blue hNOD1 cells assessed as inhibition of C12-iE-DAP-induced SEAP release preincubated for 3 hrs followed by C12-iE-DAP addition incubated for 20 hrs by spectrophotometer assay
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced ERK phosphorylation level at 1 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced p-38 phosphorylation level at 1 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced JNK phosphorylation level at 1 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced IkappaBalpha phosphorylation level at 1 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Antagonist activity at NOD1 in human THP-1 cells assessed as decrease in C12-iE-DAP-induced IkappaBalpha protein expression level at 1 uM incubated for 1 hr followed by C12-iE-DAP addition and measured for 1 hr by western blot analysis
Agonist activity at human human NOD1 expressed in HEK-Blue NOD1 reporter cells at 2 uM by colorimetry based SEAP assay
Assay data:27 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at NOD1 in HEK-Blue hNOD1 cells assessed as increase in NFkappaB activation at 10 uM incubated for 18 hrs by SEAP-based spectrophotometry analysis
Assay data:2 Tested
Agonist activity at NOD1 in HEK-Blue hNOD2 cells assessed as increase in NFkappaB transactivation-mediated SEAP activity measured after 18 hrs by spectrophotometric method
Assay data:39 Tested
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated RIP2 phoshorylation measured after 90 mins by western blot method
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated reduction in IkappaBalpha expression measured after 90 mins by western blot method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated p38 phosphorylation measured after 90 mins by western blot method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated JNK phoshorylation measured after 90 mins by western blot method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated ERK phosphorylation measured after 90 mins by western blot method
Inhibition of human NOD1 in human THP-1 cells assessed as inhibition of lauroyl-gamma-D-Glu-mDAP stimulated IL-6 m-RNA expression measured after 150 mins by Real time quantitative reverse transcriptase PCR method
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