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Transporter, GABA Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Substrate uptake by the Taurine Transporter (TauT, SLC6A6) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A6 cells (PubChem AID: 1794824)
Assay data:1 Active, 2 Tested
Substrate uptake by the Sodium- and Chloride-Dependent BetaineTransporter (BGT-1, SLC6A12) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A12 cells (PubChem AID: 1794822)
Inhibition of mouse GAT-4 assessed as inhibition of [3H]GABA uptake by liquid scintillation counter method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human BGT-1 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human GAT-1 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
Inhibition of rat GAT-2 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
Inhibition of human GAT-3 expressed in mouse L-M(TK-) cells assessed as inhibition of [3H]GABA uptake
Inhibition of mouse GAT-2 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptake
Assay data:2 Tested
Inhibition of mouse GAT-1 expressed in human HEK293 cells in presence of NO711 marker by competitive binding assay relative to control
Binding affinity to mouse GAT-1 expressed in human HEK293 cells assessed as inhibition constant in presence of NO711 marker by competitive binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse GAT-1 expressed in human HEK293 cells assessed as inhibition of [3H]GABA uptake
Assay data:2 Active, 2 Activity ≤ 1 µM, 4 Tested
Binding affinity to mouse GAT-1 assessed as inhibition constant
Inhibition of mouse GAT-1 assessed as inhibition of GABA uptake
Inhibition of [3H]-GABA uptake at GAT-1 in rat forebrain synaptosomes assessed as inhibition constant preincubated for 8 mins followed by [3H]-GABA addition measured after 8 mins by scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human GAT3 expressed in CHO cells assessed as [3H]GABA uptake at 50 uM incubated for 3 mins by top-counter microplate scintillation counter assay
Antagonist activity at human BGT1 expressed in CHO cells assessed as [3H]GABA uptake at 50 uM incubated for 3 mins by top-counter microplate scintillation counter assay
Antagonist activity at human GAT2 expressed in CHO cells assessed as [3H]GABA uptake at 50 uM incubated for 3 mins by top-counter microplate scintillation counter assay
Antagonist activity at human GAT1 expressed in CHO cells assessed as [3H]GABA uptake at 50 uM incubated for 3 mins by top-counter microplate scintillation counter assay
GABATRANS/RA Eurofins SafetyScreen44 (BI)
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