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Binding affinity to human TNF-alpha assessed as binding constant (Koff) by SPR assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
Binding affinity to human TNF-alpha assessed as binding constant (Kon) by SPR assay
Binding affinity to human TNF-alpha assessed as dissociation constant by SPR assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of TNFalpha in LPS-stimulated human mononuclear cell line by radioimmunoassay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human TNF-alpha secretion stimulated by LPS
Inhibition of TNF-alpha (unknown origin) by ELISA assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of mouse TNF-alpha in mouse L929 cells incubated for 18 hrs by CellTitreGlo assay
Inhibition of human TNF-alpha assessed as dissociation constant incubated for 5 hrs by SPR analysis
Inhibition of human TNF-alpha assessed as dissociation constant by ELISA assay
Assay data:1 Tested
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TNF-alpha RELEASE from US Patent US11365204: "Substituted dihydrothienopyrimidines and their use as phosphodiesterase inhibitors"
Assay data:67 Active, 71 Activity ≤ 1 µM, 71 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
TNF-alpha Secretion Assay from US Patent US11208399: "NLRP3 inflammasome inhibitors"
Assay data:107 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Comparison of the Effect of Corticosteroids, a ROCK Kinase and Compounds of the Invention on the Inhibition of ROCK-1 Kinase, ROCK-2 Kinase, and TNF-alpha from US Patent US11059789: "Isoquinoline-steroid conjugates and uses thereof"
TNF-alpha inducing NF-kappaB reporter from US Patent US10508103: "Benzimidazole-linked indole compound acting as novel divalent IAP antagonist"
Assay data:48 Active, 51 Activity ≤ 1 µM, 51 Tested
Cellular Necrosis Inhibition Activity from US Patent US10508102: "Inhibitors of cellular necrosis and related methods"
Assay data:9 Active, 8 Activity ≤ 1 µM, 11 Tested
Assay data:11 Active, 10 Activity ≤ 1 µM, 13 Tested
IRAK4 Monocyte TNFalpha Cell Based Assay from US Patent US10336762: "Pyrrolo[1,2-b]pyridazine derivatives"
Assay data:934 Active, 581 Activity ≤ 1 nM, 932 Activity ≤ 1 µM, 935 Tested
ELISA Assay from US Patent US9393245: "Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors"
Assay data:58 Active, 14 Activity ≤ 1 nM, 51 Activity ≤ 1 µM, 62 Tested
Surface Plasmon Resonance (SPR) Assay from Article 10.1074/jbc.M113.521708: "A novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model."
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Biological Assay from US Patent US9120838: "Saccharide conjugates"
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
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