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Inhibition of human GAL4-fused RORalpha LBD transfected in HEK293T cell measured after 24 hrs by luciferase reporter assay
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Inverse agonist activity at human GAL4-fused RORalpha LBD transfected in 293T cell measured after 24 hrs by dual luciferase assay
Assay data:6 Tested
Inverse agonist activity at human GAL4-fused RORbeta LBD transfected in 293T cell measured after 24 hrs by dual luciferase assay
Inhibition of human GAL4-fused RORbeta LBD transfected in HEK293T cell measured for 16 to 20 hrs by by dual-glo luciferase assay
Assay data:1 Tested
Inhibition of human GAL4-fused RORalpha LBD transfected in HEK293T cell measured for 16 to 20 hrs by by dual-glo luciferase assay
Inverse agonist activity at 6His-tagged RORB LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay
Inverse agonist activity at 6His-tagged RORA LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of biotinylated SRC1-2 derived CPSSHSSLTERHKILHRLLQEGSPS-NH2 containing LXXLL coactivator peptide incubated for 3 hrs by TR-FRET assay
Inhibition of RORbeta (unknown origin) assessed as fold change
Inhibition of RORalpha (unknown origin) assessed as fold change
Inhibition of GAL4 DNA-binding domain fused full length human RORbeta (201 to 459 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by one hybrid reporter assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GAL4 DNA-binding domain fused full length human RORalpha (305 to 556 residues) expressed in HEK293T cells incubated for 16 to 20 hrs by one hybrid reporter assay
Agonist activity at human RORalpha at up to 3 uM by nuclear reporter assay
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to RORbeta (unknown origin)
Binding affinity to RORalpha (unknown origin)
Receptor Competition Binding Assay from US Patent US11008336: "Compounds useful for inhibiting RORγt"
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
RORa, b, and g Binding Inhibitors from US Patent US10603320: "Compounds useful for inhibiting ROR-gamma-t"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Biological Assay from US Patent US9598431: "Compounds useful for inhibiting ROR-gamma-t"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
ThermoFluor Binding Assay (RORB)
Assay data:2 Tested
ThermoFluor Binding Assay (RORA)
Agonist activity at RORbeta (unknown origin)
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