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Inhibition of human ADCY1 assessed assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as substrate by sequential chromatographic analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Ca2+/ CAM stimulated human AC1 activity expressed in AC3 and AC6-knockout HEK293 cells assessed as A23187 stimulated cAMP accumulation incubated for 30 mins followed by A2318 stimulation in presence of IBMX for 1 hr by HTRF assay
Assay data:33 Active, 22 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human AC1 expressed in HEK293 cells assessed as remaining activity by measuring cAMP level at 30 uM relative to control
Assay data:24 Tested
Agonist activity at recombinant human AC1 expressed in HEK293 cells assessed as increase in cAMP level at 50 uM measured after 30 mins by LANCE Ultra cAMP Detection kit method
Agonist activity at recombinant human AC1 expressed in human HEK293 cells assessed as increase in cAMP level at 50 uM by LANCE Ultra cAMP Detection kit
Inhibition of human AC1 expressed in HEK293 AC3/AC6 deficit cells assessed as decrease in forskolin-stimulated cAMP accumulation preincubated for 30 mins followed by forskolin stimulation and measured after 1 hr by fluorescence assay
Assay data:2 Tested
Inhibition of human AC1 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation at 30 uM preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay relative to control
Assay data:3 Tested
Inhibition of human AC1 expressed in HEK293 cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr by fluorescence assay
Assay data:45 Active, 1 Activity ≤ 1 µM, 68 Tested
Inhibition of AC1 (unknown origin) expressed in HEK cells assessed as decrease in A23187-stimulated cAMP accumulation preincubated for 30 mins followed by A23187 stimulation and measured after 1 hr
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of AC1 (unknown origin) expressed in HEK293 cells assessed as decrease in Ca2+/calmodulin-mediated cAMP accumulation by enzyme immunoassay
Activation of adenylyl cyclase (unknown origin) at 10 uM
Inhibition of forskolin-stimulated adenylyl cyclase (unknown origin)
Inhibition of adenylyl cyclase (unknown origin)
Inhibition of bPTH-stimulated adenylyl cyclase (unknown origin) activity at 500:1 compound to native hormone molar ratio
Agonist activity at adenylyl cyclase (unknown origin) at 1.35 x 10'-4 M
Inhibition of forskolin-stimulated adenylyl cyclase 1 activity expressed in HEK293 cells at 100 uM
Assay data:1 Active, 2 Tested
Inhibition of forskolin-stimulated human transmembrane adenylyl cyclase activity in HEK293 cells at 100 uM
KB for inhibition of adenylate cyclase stimulation in human platelet membranes
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of [125 I]6-IHPP-forskolin binding to Adenylate cyclase 1
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