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Affinity On-target Cellular interaction (Cellular activity assay (measurement of ATP levels in presence of complex II substrate succinate in H1299 cells)) EUB0000752a NDUFS2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (Cellular activity assay (measurement of ATP levels in presence of complex II substrate succinate in H1299 cells)) EUB0000748a NDUFS2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Proliferation assay (CellTiter-Glo ATP assay in human lung H1299 cells)) EUB0000752a NDUFS2
Proliferation assay with cellular ATP kit HTS
Proliferation assay with CellTiter-Glo ATP
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay
Assay data:4 Active, 2 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1,10-phenanthroline-induced HIF1 activation incubated for 30 mins prior to 1,10-phenanthroline-challenge measured after 16 hrs by luciferase reporter assay
Assay data:4 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1,10-phenanthroline-induced HIF1 activation at 30 uM incubated for 30 mins prior to 1,10-phenanthroline-challenge measured after 16 hrs by luciferase reporter assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mitochondrial ETC complex 1 in human T47D cells assessed as inhibition of 1% O2-induced HIF1 activation at 30 uM incubated for 30 mins prior to 1% O2-challenge measured after 16 hrs by luciferase reporter assay
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